IL-20 Protein

Catalog No. ABIN988057

IL-20 protein expressed in Escherichia coli (E. coli).

Quick Overview for IL-20 Protein (ABIN988057)

Target: IL-20 (IL20) (Interleukin 20 (IL20))

Biological Activity: Active

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 95 % by SDS-PAGE and HPLC analyses.

Product Details

Sequence: MLKTLNLGSC VIATNLQEIR NGFSEIRGSV QAKDGNIDIR ILRRTESLQD TKPANRCCLL RHLLRLYLDR VFKNYQTPDH YTLRKISSLA NSFLTIKKDL RLCHAHMTCH CGEEAMKKYS QILSHFEKLE PQAAVVKALG ELDILLQWME ET

Characteristics: Fully biologically active when compared to standard. The ED50 determined by a cell proliferation assay using human IL-20Ralpha and human IL-20Rbeta co-transfected murine BaF3 pro-B cells is less than 0.6 ng/ml, corresponding to a specific activity of >, 1.7 × 106 IU/mg.

Endotoxin Level: Level Less than 1EU/µg of rHuIL-20 as determined by LAL method

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.

Storage: 4 °C

Target Details

Target: IL-20 (IL20) (Interleukin 20 (IL20))

Alternative Name: Interleukin-20 (IL-20)

Background: IL-20 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. IL-20 is a hematopoietic growth factor capable of stimulating colony formation by CD34+ multipotential progenitors, but not by other progenitor cells. IL-20 signals through a receptor system composed of type I IL-20R-ª and type II IL-20R-beta. Over-expression of IL-20 in keratinocytes expressing both receptor subunits has been implicated in the induction of inflammatory skin disease. Synonym: Interleukin-20 (IL-20), Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.

Molecular Weight: Approximately 17.6 kDa, a single non-glycosylated polypeptide chain containing 153 amino acids.

Pathways: Protein targeting to Nucleus