IL-31 Protein
Quick Overview for IL-31 Protein (ABIN988074)
Target
See all IL-31 (IL31) ProteinsBiological Activity
Origin
Source
Purity
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Sequence
- SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT
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Characteristics
- Fully biologically active when compared to standard.Measured by its ability to induce STAT3 activation in U-87 MG human glioblastoma/astrocytoma cells. 5 ng/mL of rhIL31 can effectively induce STAT3 activation.
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Endotoxin Level
- Level Less than 1EU/µg of rHuIL-31 as determined by LAL method
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Interleukin 31 (IL31) (AA 24-164) protein (His tag)
IL31 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 31 (IL31) (AA 27-163) protein (His tag)IL31 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 31 (IL31) (AA 24-163) protein (His tag)IL31 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Interleukin 31 (IL31) (AA 24-164) protein (Fc Tag)IL31 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 31 (IL31) (AA 24-159) protein (His tag)IL31 Origin: Dog Host: Baculovirus infected Insect Cells Recombinant > 95% by SDS-PAGE SDS
Interleukin 31 (IL31) proteinIL31 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant 97,00% SDS
Interleukin 31 (IL31) (AA 24-164) (Active) protein (His tag)IL31 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Interleukin 31 (IL31) proteinIL31 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant 97,00% SDS
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20°C. Further dilutions should be made in appropriate buffered solutions.
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Storage
- 4 °C
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- IL-31 (IL31) (Interleukin 31 (IL31))
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Alternative Name
- Interleukin-31 (IL-31)
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Background
- Human IL-31 is a T-cell derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL-31RA) and OSMR (Oncostatin M receptor). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Synonym:. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in PBS,pH 7.4.
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Molecular Weight
- Approximately 15.8 kDa, a single non-glycosylated polypeptide chain containing 141 amino acids.
Target
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