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anti-Mouse (Murine) alpha Actinin 4 Antibodies:
anti-Rat (Rattus) alpha Actinin 4 Antibodies:
anti-Human alpha Actinin 4 Antibodies:
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Cow (Bovine) Polyclonal alpha Actinin 4 Primary Antibody for IHC, WB - ABIN2775288
Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France. in Diagnostic microbiology and infectious disease 2006
Show all 3 Pubmed References
Human Monoclonal alpha Actinin 4 Primary Antibody for ELISA, FACS - ABIN261463
Koo, Apte: Cell-surface processing of the metalloprotease pro-ADAMTS9 is influenced by the chaperone GRP94/gp96. in The Journal of biological chemistry 2009
Human Polyclonal alpha Actinin 4 Primary Antibody for FACS, IHC (p) - ABIN392219
Kikuchi, Honda, Tsuda, Hiraoka, Imoto, Kosuge, Umaki, Onozato, Shitashige, Yamaguchi, Ono, Tsuchida, Aoki, Inazawa, Hirohashi, Yamada: Expression and gene amplification of actinin-4 in invasive ductal carcinoma of the pancreas. in Clinical cancer research : an official journal of the American Association for Cancer Research 2008
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Cow (Bovine) Polyclonal alpha Actinin 4 Primary Antibody for WB - ABIN2775289
Kimura, Wakamatsu, Suzuki, Ota, Nishikawa, Yamashita, Yamamoto, Sekine, Tsuritani, Wakaguri, Ishii, Sugiyama, Saito, Isono, Irie, Kushida, Yoneyama, Otsuka, Kanda, Yokoi, Kondo, Wagatsuma, Murakawa et al.: Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. ... in Genome research 2006
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Human Polyclonal alpha Actinin 4 Primary Antibody for ICC, IF - ABIN4279711
Stadler, Hjelmare, Neumann, Jonasson, Pepperkok, Uhlén, Lundberg: Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. in Journal of proteomics 2012
Human Monoclonal alpha Actinin 4 Primary Antibody for IF, IHC (p) - ABIN559759
Yamada, Yanamoto, Yoshida, Yoshitomi, Kawasaki, Mizuno, Nemoto: RNAi-mediated down-regulation of alpha-actinin-4 decreases invasion potential in oral squamous cell carcinoma. in International journal of oral and maxillofacial surgery 2010
Focal segmental glomerulosclerosis Actn4 mutation promotes podocyte detachment through maladaptation to periodic stretch.
ACTN4 is a transcriptional coactivator of NF-kappaB (show NFKB1 Antibodies).
UCHL1 (show UCHL1 Antibodies) upregulation in ACTN4-associated FSGS.
sLZIP negatively regulates skeletal muscle differentiation via interaction with ACTN4.
the C-terminal tail of alpha-actinin-4 is essential for its function in cell migration and adhesion to substratum.
Dexamethasone mey protect actin cytoskeleton stabilization from adriamycin-induced podocyte injury via alpha-actinin-4.
anti-dsDNA Fab (show FANCB Antibodies) may enhance F-actin formation by the proprietary modification of alpha-actinin-4
Together, these results indicate that alpha-actinin (show ACTN1 Antibodies) and the actin cytoskeleton are important components of the cisternal organelle that are probably required to stabilize the AIS (show AR Antibodies).
Results suggest that ACTN4 is essential for maintaining normal spreading, motility, cellular and nuclear cross-sectional area, and contractility of lung fibroblasts by maintaining the balance between transcellular contractility and cell-adhesion.
newly developed mouse model of ACTN4-associated FSGS suggests a cause-and-effect relationship between actin cytoskeleton dysregulation by mutant alpha-actinin-4 and the deterioration of the nephrin (show NPHS1 Antibodies)-supported slit diaphragm complex.
Data suggest that TYRO3 (show TYRO3 Antibodies)-mediated phosphorylation of ACTN4 is involved in invasiveness of melanoma cells; TYRO3 (show TYRO3 Antibodies)-mediated phosphorylation of ACTN4 requires FAK (show PTK2 Antibodies) activation at tyrosine 397. (TYRO3 (show TYRO3 Antibodies) = TYRO3 protein tyrosine kinase (show TYRO3 Antibodies); ACTN4 = actinin alpha 4; FAK (show PTK2 Antibodies) = focal adhesion kinase isoform FAK1 (show PTK2 Antibodies))
ACTN4 knockdown resulted in the blockage of malignant cell proliferation, colony formation, and ameliorated metastasis potency. ACTN4-positive CSCs exhibited a higher ESA (show FLOT2 Antibodies)(+) proportion, increased mammosphere-formation ability, and enhanced in vivo tumorigenesis ability.
These results demonstrate that both actinin (show ACTN1 Antibodies)-1 and actinin-4 participate in the assembly of F-actin at invadopodia. Additionally, actinin-4 may have a selective advantage in accelerating invadopodia-mediated invasion of carcinoma cells.
Gene amplification of ACTN4 was a significant independent risk factor for death in patients with stage I/II oral tongue cancer (hazard ratio 6.08, 95% confidence interval 1.66-22.27). Gene amplification of ACTN4 is a potential prognostic biomarker for overall survival in oral tongue cancer.
ACTN4 knockdown near-completely abrogates both radioresistance and epithelial-mesenchymal transition-associated changes in breast cancer cells.
Fascin and alpha-actinin intrinsically segregate to discrete bundled domains that are specifically recognized by other actin-binding proteins.
Suggest that ACTN4 as a potential predictive biomarker for efficacy of adjuvant chemotherapy in stage-IB/II patients with non-small cell lung cancer, by reflecting the metastatic potential of tumor cells.
High ACTN4 expression is associated with Lung Squamous Cell Carcinoma.
Our findings indicate that ACTN4 promotes EMT (show ITK Antibodies) and tumorigenesis by regulating Snail (show SNAI1 Antibodies) expression and the Akt (show AKT1 Antibodies) pathway in cervical cancer. We propose a novel mechanism for EMT (show ITK Antibodies) and tumorigenesis in cervical cancer.
Study found a functional Validation of an Alpha-Actinin-4 Mutation as a Potential Cause of an Aggressive Presentation of Adolescent Focal Segmental Glomerulosclerosis.
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.
actinin, alpha 4
, F-actin cross-linking protein
, non-muscle alpha-actinin 4
, alpha actinin 4
, actinin alpha4 isoform
, focal segmental glomerulosclerosis 1