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alpha Actinin 4 Products

(Actinin, alpha 4 (ACTN4))

Categories

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008].

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Featured alpha Actinin 4 Categories

alpha Actinin 4 Antibodies

High quality antibodies with extensive validation data.

alpha Actinin 4 ELISA Kits

Reliable ELISA kits for a wide range of species.

alpha Actinin 4 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended alpha Actinin 4 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IF, IHC (p)
Validations
  • (1)
  • (12)
Cat. No. ABIN559759
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (6)
Cat. No. ABIN7440797
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF, IHC (p), ICC
Validations
  • (7)
Cat. No. ABIN2855119
Quantity 100 μL
Datasheet Datasheet

Recommended alpha Actinin 4 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6964559
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6953411
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method
Validations
Cat. No. ABIN1121247
Quantity 96 tests
Datasheet Datasheet

Recommended alpha Actinin 4 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1305772
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7121665
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1305774
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our alpha Actinin 4 products

Wang, Li, Wang, Tan, Jia, Yang, Li, Shang, Xu, Yang, Shoyama, Cai: "Alpha-Actinin-4 is a Possible Target Protein for Aristolochic Acid I in Human Kidney Cells In Vitro." in: The American journal of Chinese medicine, Vol. 44, Issue 2, pp. 291-304, (2016) (PubMed).

Van Raemdonck, Tjalma, Coen, Depuydt, Van Ostade: "Identification of protein biomarkers for cervical cancer using human cervicovaginal fluid." in: PLoS ONE, Vol. 9, Issue 9, pp. e106488, (2014) (PubMed).

Shao, Li, Watkins, Wells: "α-Actinin-4 is required for amoeboid-type invasiveness of melanoma cells." in: The Journal of biological chemistry, Vol. 289, Issue 47, pp. 32717-28, (2014) (PubMed).

Karlsson, Turkina, Yakymenko, Magnusson, Vikström: "The Pseudomonas aeruginosa N-acylhomoserine lactone quorum sensing molecules target IQGAP1 and modulate epithelial cell migration." in: PLoS pathogens, Vol. 8, Issue 10, pp. e1002953, (2012) (PubMed).

Stadler, Hjelmare, Neumann, Jonasson, Pepperkok, Uhlén, Lundberg: "Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy." in: Journal of proteomics, Vol. 75, Issue 7, pp. 2236-51, (2012) (PubMed).

Wei, Gao, Du, Su, Xu: "Angiogenin enhances cell migration by regulating stress fiber assembly and focal adhesion dynamics." in: PLoS ONE, Vol. 6, Issue 12, pp. e28797, (2011) (PubMed).

Yamada, Yanamoto, Yoshida, Yoshitomi, Kawasaki, Mizuno, Nemoto: "RNAi-mediated down-regulation of alpha-actinin-4 decreases invasion potential in oral squamous cell carcinoma." in: International journal of oral and maxillofacial surgery, Vol. 39, Issue 1, pp. 61-7, (2010) (PubMed).

Koo, Apte: "Cell-surface processing of the metalloprotease pro-ADAMTS9 is influenced by the chaperone GRP94/gp96." in: The Journal of biological chemistry, Vol. 285, Issue 1, pp. 197-205, (2009) (PubMed).

Klaiman, Petzke, Hammond, Leblanc: "Targets of caspase-6 activity in human neurons and Alzheimer disease." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 8, pp. 1541-55, (2008) (PubMed).

Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: "Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France." in: Diagnostic microbiology and infectious disease, Vol. 55, Issue 1, pp. 55-8, (2006) (PubMed).

Synonyms and alternative names related to alpha Actinin 4

actinin alpha 4 (actn4), actinin alpha 4 (ACTN4), actinin alpha 4 (Actn4), actinin, alpha 4 (actn4), actinin alpha 4 S homeolog (actn4.S), actinin, alpha 4 (ACTN4), ACTININ-4, C77391, fsgs, FSGS, fsgs1, FSGS1, wu:fb53f05, zgc:63508

Protein level used designations for alpha Actinin 4

  • actinin, alpha 4
  • alpha-actinin-4-like
  • F-actin cross-linking protein
  • alpha-actinin-4
  • non-muscle alpha-actinin 4
  • alpha actinin 4
  • actinin alpha4 isoform
  • focal segmental glomerulosclerosis 1
  • alpha-actinin
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