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Studies indicate some of the functional and mechanistic roles of the binder of Rho GTPases Borg1-5 proteins (Cdc42EP1-5), including cytoskeletal remodelling and signalling.
CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. The specific function of this protein has not yet been determined.
CDC42 effector protein (Rho GTPase binding) 5
, CDC42 effector protein 5
, binder of Rho GTPases 3
, cdc42 effector protein 5
, CRIB-containing BORG3 protein
, binder of Rho GTPase 3