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anti-Human TRPV2 Antibodies:
anti-Rat (Rattus) TRPV2 Antibodies:
anti-Mouse (Murine) TRPV2 Antibodies:
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Human Polyclonal TRPV2 Primary Antibody for IHC (fro), IF - ABIN542624
Caterina, Rosen, Tominaga, Brake, Julius: A capsaicin-receptor homologue with a high threshold for noxious heat. in Nature 1999
Show all 4 Pubmed References
Rat (Rattus) Polyclonal TRPV2 Primary Antibody for ELISA, WB - ABIN314242
Saunders, Kunde, Crawford, Geraghty: Expression of transient receptor potential vanilloid 1 (TRPV1) and 2 (TRPV2) in human peripheral blood. in Molecular immunology 2006
Human Polyclonal TRPV2 Primary Antibody for ICC, IHC - ABIN442072
Lo, Tjong, Ho, Siu, Cheung, Tang, Yu, Tse, Yao et al.: An upregulation in the expression of vanilloid transient potential channels 2 enhances hypotonicity-induced cytosolic Ca²⁺ rise in human induced pluripotent stem cell model of Hutchinson-Gillford ... in PLoS ONE 2014
This study presents the atomic model of rabbit TRPV2 in its putative desensitized state, as determined by cryo-EM at a nominal resolution of approximately 4 A.
Study shows that despite lacking gastric mucosal inflammation, up-regulation of TRPV1 and TRPV2, down-regulation of BDNF were observed in functional dyspepsia (FD) patients. These suggest that immune alteration may contribute to the pathogenesis of FD without any previous infection.
TRPV2 recruitment to lipid rafts and TRPV2-mediated calcium influx are required for phagocytosis in macrophages from cystic fibrosis patients.
TRPV2 regulates key intracellular processes implicated in cell invasion in arthritis
TRPV2-induced Ca(2+)-calcineurin-NFAT signaling regulates differentiation of osteoclast in multiple myeloma
TRPV2 mediates IL-8 secretion and calcium signaling in testicular peritubular cells.
TRPV2 expression was inversely correlated with CRP and TpI and directly correlated with serum IGF-1. We assume that peripheral TRPV2 downregulation occurs concomitantly with the accumulation of TRPV2-white blood cells in the peri-infarct zone. TRPV2 may thus represent a novel target for treatment in the acute phase after MI.
the expression of transient receptor potential vanilloid-1 (TRPV1), transient receptor potential vanilloid-2 (TRPV2) and transient receptor potential vanilloid-3 (TRPV3) channels in native human odontoblasts, was examined.
High TRPV2 expression is associated with breast cancer.
Binding of capsaicin to TRPV2_Quad antagonizes resiniferatoxin-induced activation likely through competition for the same binding sites.
both TRPV2 and TRPV4 are involved in migration of human cardiac c-kit(+) progenitor cells.
The results of the study show that polymorphism of TRPV2 influenced the susceptibility to FM.
CGRP- and TRPV2-containing trigeminal neurons probably innervate the paranasal sinus mucosae, and project into spinal and principal trigeminal sensory nuclei.
transient receptor potential vanilloid 2 is an intracellular Ca(2+)-permeable transient receptor potential vanilloid channel upregulated by nerve growth factor via the mitogen-activated protein kinase signaling pathway to augment neurite outgrowth.
Using multiple sequence alignments as source for evolutionary, bioinformatics and statistical analysis, we have analyzed the evolutionary profiles for TRPV1, TRPV2, TRPV3 and TRPV4
There appears to be TRPV1- or TRPV2-IR sympathetic pathway in the human stellate ganglion and spinal cord.
This study evaluated the role of Trpv2 in arthritis and the pharmacological effects of Trpv2 agonists.
High expression of TRPV2 mRNA was closely associated with advanced pathological stage and worse survival of patients with esophageal squamous cell carcinoma.
Aim of this review is to study the role of the TRPV2 channel, a member of the TRPV subfamily of TRP channels, in tumor progression. [review]
TRPV1-, TRPV2-, P2X3-, and parvalbumin-immunoreactivity neurons in the human nodose ganglion innervate the pharynx and epiglottis through the pharyngeal branch and superior laryngeal nerve
Data indicate that transient receptor potential vanilloid 2 (TRPV2) siRNA virtually abolished stretch-activated current.
The mast cell is the central structure of acupoints and is activated by acupuncture through TRPV2 channels.
TRPV2 expression is profoundly downregulated in alveolar macrophages at early time points of cigarette smoke exposure. Reduced TRPV2-mediated phagocytic function renders the lung susceptible to cigarette smoke-induced alveolar space enlargement.
data suggest that knockout of the TRPV2 channel may attenuate macrophage-dependent pro-inflammatory processes and result in better cardiac recovery. TRPV2 may thus represent a novel therapeutic target for treatment of patients undergoing an acute MI
We conclude that TRPV2 function, as a stretch-activated channel, regulates the development of cardiomyocyte hypertrophy in response to increased afterload.
These findings suggest that TRPV2 activation via actin reorganization induced by Gq and G12/13 signaling is involved in LPI-stimulated GLP-1 secretion in enteroendocrine L cells.
Expression of TRPV2 was dramatically increased during the differentiation of brown adipocytes. TRPV2 might be involved in the modulation of brown adipocyte differentiation partially via a calcineurin pathway.
TRPV2 channels are demonstrated here to play a key role in cation influx and dysregulation in dystrophin deficient cardiomyocytes, enhanced in stretching conditions
TRPV2KO mice show cold intolerance and impaired BAT thermogenesis.
We conclude that TRPV2 is involved in osmosensation in skeletal muscle fibres, acting in concert with P-SPAK-activated NKCC1
TRPV2-knockout mice have impaired cardiac functional response to exercise.
TRPV2 channels play a predominant role in fluid flow mechanosensitivity over that of TRPC1 and TRP melastatin (TRPM) 7.
TRPV2 is involved in a stretch-activated calcium influx pathway in dystrophic cardiomyopathy, contributing to the defective cellular Ca2+ handling in this disease.
We found that NA indeed potentiated TRPV3 while inhibited TRPV2 and TRPV4
This study suggests that TRPV2 coupled with IGF-IR localizes to growing olfactory axons in the olfactory sensory neurons.
Compared to Wt mice, reduced severity of colitis in TRPV2-/- mice may be due to less intestinal inflammation via reduced recruitment of macrophages.
Cannabidiol rapidly increased TRPV2 expression and caused the translocation of TRPV2 to the cell membrane.
Sarcolemmal TRPV2 accumulation appears to have considerable pathological impact on Dilated cardiomyopathy (DCM) progression.
the activity of this channel is necessary for normal cardiac function
TRPV2 is functionally expressed in astrocytes in addition to neurons.
This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat.
transient receptor potential cation channel, subfamily V, member 2
, transient receptor potential cation channel subfamily V member 2
, transient receptor potential cation channel subfamily V member 2-like
, osm-9-like TRP channel 2
, vanilloid receptor-like protein 1
, stretch-activated channel 2B
, growth factor regulated channel
, growth factor-regulated calcium channel