CLCF1 Proteins

Protein Summary

This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Alternative names and synonyms associated with CLCF1

• cardiotrophin like cytokine factor 1 (clcf1) antibody
• cardiotrophin like cytokine factor 1 (CLCF1) antibody
• cardiotrophin-like cytokine factor 1 (Clcf1) antibody
• cardiotrophin like cytokine factor 1 (Clcf1) antibody
• cardiotrophin-like cytokine factor 1 (CLCF1) antibody

• BSF-3 antibody
• Bsf3 antibody
• CISS2 antibody
• Clc antibody
• CLCF1 antibody
• Show all synonym aliases
• NNT-1 antibody
• NNT1 antibody
• NR6 antibody

Protein level used designations for CLCF1

cardiotrophin-like cytokine factor 1 , B-cell stimulating factor 3 , B-cell stimulatory factor 3 , B-cell-stimulating factor 3 , CRLF1 associated cytokine-like factor 1 , neurotrophin-1/B-cell stimulating factor-3 , novel neurotrophin-1 , BSF-3 , NNT-1 , NNT-1/BSF-3 , b cell-stimulating factor 3 , cardiotrophin-like cytokine