Browse our Cardiotrophin-Like Cytokine Factor 1 Proteins (CLCF1)

This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

• cardiotrophin like cytokine factor 1 (clcf1)
• cardiotrophin like cytokine factor 1 (CLCF1)
• cardiotrophin-like cytokine factor 1 (Clcf1)
• cardiotrophin like cytokine factor 1 (Clcf1)
• cardiotrophin-like cytokine factor 1 (CLCF1)

• BSF-3 protein
• Bsf3 protein
• CISS2 protein
• Clc protein
• CLCF1 protein
• Show all synonym aliases
• NNT-1 protein
• NNT1 protein
• NR6 protein

cardiotrophin-like cytokine factor 1 , B-cell stimulating factor 3 , B-cell stimulatory factor 3 , B-cell-stimulating factor 3 , CRLF1 associated cytokine-like factor 1 , neurotrophin-1/B-cell stimulating factor-3 , novel neurotrophin-1 , BSF-3 , NNT-1 , NNT-1/BSF-3 , b cell-stimulating factor 3 , cardiotrophin-like cytokine