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CLF-1 (show CRLF1 Proteins), based on its binding site for CLC (show CLC Proteins) and on two additional and independent sites for CNTFRalpha (show CNTFR Proteins) and sorLA (show SORL1 Proteins), is a key player in CLC (show CLC Proteins) and CNTFRalpha (show CNTFR Proteins) signaling and turnover.
Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP (show CTF2 Proteins)) signalling and their roles in development, adulthood, cancer and degenerative disorders.
albuminuria in focal segmental glomerulosclerosis is related to qualitative or quantitative changes in the CLCF1-CRLF1 (show CRLF1 Proteins) complex.
activation of the Jak (show JAK3 Proteins)-STAT (show STAT1 Proteins) cascade is essential for corticotroph NNT-1/BSF-3 signaling.
Structural and docking interaction studies showed that the R197L substitution destabilized the contact site between CLC (show CLC Proteins) and CNTFRalpha (show CNTFR Proteins).
Ciliary neurotrophic factor (show CNTF Proteins), cardiotrophin-like cytokine, and neuropoietin (show CTF2 Proteins) share a conserved binding site on the ciliary neurotrophic factor receptor alpha (show CNTFR Proteins) chain (show FCGRT Proteins)
CLC (show CLC Proteins) plays a role in astrocyte differentiation via STAT3 (show STAT3 Proteins) activation within the developing brain
neurotrophin-1/B-cell stimulating factor 3(NNT-1/BSF-3) is expressed in pituitary folliculostellate TtT/GF cells and induced by PKC-, PKA-, and ERK1/2-dependent mechanisms
IL-6 (show IL6 Proteins) (gp130 (show LRPPRC Proteins)) family cytokine members include CLC/NNT1/BSF3 and IL-27 (show IL27 Proteins) [review]
In this study, Clc (show CLC Proteins) knockout mice had decreased facial motility, did not suckle, died within 24 hours, and had 32% and 29% fewer motor neurons in the facial nucleus and lumbar ventral horn, respectively.
This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
cardiotrophin-like cytokine factor 1
, B-cell stimulating factor 3
, B-cell stimulatory factor 3
, B-cell-stimulating factor 3
, CRLF1 associated cytokine-like factor 1
, neurotrophin-1/B-cell stimulating factor-3
, novel neurotrophin-1
, b cell-stimulating factor 3
, cardiotrophin-like cytokine