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CLCF1 Products

(Cardiotrophin-Like Cytokine Factor 1 (CLCF1))
This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009].

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Featured CLCF1 Categories

CLCF1 Antibodies

High quality antibodies with extensive validation data.

CLCF1 ELISA Kits

Reliable ELISA kits for a wide range of species.

CLCF1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CLCF1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7189455
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (1)
Cat. No. ABIN7146821
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (1)
Cat. No. ABIN525227
Quantity 200 μL
Datasheet Datasheet

Recommended CLCF1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6954374
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6974988
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6954375
Quantity 96 tests
Datasheet Datasheet

Recommended CLCF1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3091679
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3130613
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN2712862
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our CLCF1 products

Herholz, Meloni, Marongiu, Chiappe, Deiana, Herrero, Zampino, Hamamy, Zalloum, Waaler, Crisponi, Crisponi, Rutsch: "Differential secretion of the mutated protein is a major component affecting phenotypic severity in CRLF1-associated disorders." in: European journal of human genetics : EJHG, Vol. 19, Issue 5, pp. 525-33, (2011) (PubMed).

Synonyms and alternative names related to CLCF1

cardiotrophin like cytokine factor 1 (clcf1), cardiotrophin like cytokine factor 1 (CLCF1), cardiotrophin-like cytokine factor 1 (Clcf1), cardiotrophin like cytokine factor 1 (Clcf1), cardiotrophin-like cytokine factor 1 (CLCF1), BSF-3, bsf3, BSF3, Bsf3, ciss2, CISS2, clc, CLC, Clc, CLCF1, NNT-1, nnt1, NNT1, nr6, NR6

Protein level used designations for CLCF1

  • cardiotrophin-like cytokine factor 1
  • B-cell stimulating factor 3
  • B-cell stimulatory factor 3
  • B-cell-stimulating factor 3
  • CRLF1 associated cytokine-like factor 1
  • neurotrophin-1/B-cell stimulating factor-3
  • novel neurotrophin-1
  • BSF-3
  • NNT-1
  • NNT-1/BSF-3
  • b cell-stimulating factor 3
  • cardiotrophin-like cytokine
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