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Low NKp30 expression on NK cells is associated with Nasopharyngeal Carcinoma.
we propose NKp30 status as a simple and early prognostic biomarker that identifies intermediate-risk patients with poor prognosis who otherwise may not be identified with existing risk stratification systems.
Data indicate a sequence of events driven by tumour-derived prostaglandin D2 (PGD2 (show PTGDS Proteins)) associated with engagement of the natural cytotoxicity triggering receptor 3 (NKp30)-B7H6 (show NCR3LG1 Proteins) antigen (B7H6 (show NCR3LG1 Proteins)) pathway leading to significant group 2 innate lymphoid cells (ILC2s) activation and expansion.
NKp44 (show NCR2 Proteins) and NKp30 splice variants profiles are tissue/condition specific and demonstrate similarity between placenta and cancerous tissues.
Results found that rs2736191-C NCR3 carriers had a significant increased number of mild malaria episodes compared to the non-carriers. This SNP had a significantly increased promoter activity in NCR33 gene and involves a binding site for STAT4 (show STAT4 Proteins) and RUNX3 (show RUNX3 Proteins).
findings show HIV reservoir size is dependent on the presence of a defined NK cell population with a specific transcriptional signature: high NCR (NKp46 (show NCR1 Proteins) and NKp30) and IFN-gamma (show IFNG Proteins) inducibility upon NCR and cytokine receptor (show EBI3 Proteins) engagement
Copy number variations of HLA-I and activation of NKp30 pathway determine the sensitivity of gastric cancer cells to the cytotoxicity of natural killer cells
Data suggest that NK cells and NKp30 could play a role in Antisynthetase syndrome pathogenesis.
the stalk domains of NKp30 and NKp46 (show NCR1 Proteins), another NCR employing CD3zeta (show CD247 Proteins) for signaling, were not exchangeable without drastic deficiencies in folding, plasma membrane targeting, and/or ligand-induced receptor signaling.
Age and CMV serostatus influence the expression of NKp30, NKp46 (show NCR1 Proteins) and DNAM-1 (show CD226 Proteins) activating receptors on resting and IL-2 (show IL2 Proteins) activated natural killer cells.
phenotypic, molecular, and functional characterization for triggering molecules (NKp46 (show NCR1 Proteins), NKp30 NKp80 (show KLRF1 Proteins), and NKG2D (show KLRK1 Proteins); in this AIDS-resistant species, relevant differences to human NK cells involve NKp80 (show KLRF1 Proteins) and particularly NKp30
The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.
natural cytotoxicity triggering receptor 3
, activating NK-A1 receptor
, activating natural killer receptor p30
, lymphocyte antigen 117
, natural killer cell p30-related protein
, NK receptor 1c7
, natural killer cell p30-related