NCR3 Protein (AA 19-138) (His tag)
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- Target See all NCR3 Proteins
- NCR3 (Natural Cytotoxicity Triggering Receptor 3 (NCR3))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 19-138
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Origin
- Human
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Source
- Human Cells
- Purification tag / Conjugate
- This NCR3 protein is labelled with His tag.
- Purpose
- Recombinant Human NCR3/NKp30/CD337 (C-6His)
- Sequence
- LWVSQPPEIR TLEGSSAFLP CSFNASQGRL AIGSVTWFRD EVVPGKEVRN GTPEFRGRLA PLASSRFLHD HQAELHIRDV RGHDASIYVC RVEVLGLGVG TGNGTRLVVE KEHPQLGAGT VDHHHHHH
- Characteristics
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Recombinant Human NCR3/NKp30/CD337 (C-6His)
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Sterility
- 0.2 μm filtered
- Endotoxin Level
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
- Top Product
- Discover our top product NCR3 Protein
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Reconstitution
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. - Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
- Handling Advice
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
- Storage
- 4 °C/-20 °C/-80 °C
- Storage Comment
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Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- NCR3 (Natural Cytotoxicity Triggering Receptor 3 (NCR3))
- Alternative Name
- Natural Cytotoxicity Triggering Receptor 3/NCR3 (NCR3 Products)
- Synonyms
- MGC133750 Protein, 1C7 Protein, CD337 Protein, LY117 Protein, MALS Protein, NKp30 Protein, Nkp30 Protein, natural cytotoxicity triggering receptor 3 Protein, NCR3 Protein, Ncr3 Protein
- Background
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Recombinant Human Natural Cytotoxicity Triggering Receptor 3/NCR3 is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (Leu19-Thr138) of Human NCR3.
Natural Cytotoxicity Triggering Receptor 3 (NCR3) along with NKp44 and NKp46 constitute a group of receptors termed 'Natural Cytotoxicity Receptors'. They play a major role in triggering NK-mediated killing of most tumor cells lines. NKp30 is a type I transmembrane protein having a single extracellular V-like immunoglobulin domain. NKp30 is selectively expressed both in resting and activated human NK cells. In addition, NKp30 is also involved in NK-mediated induction of dendritic cell (DC) maturation. It has been demonstrated that NK cell activation signaling specifically induces lytic activity against several tumor cell types and synthesis of new NF-κB dependent proteins during the initiation of cytotoxicity. - Molecular Weight
- 12.84 kDa
- UniProt
- O14931
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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