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Cow (Bovine) Polyclonal CDON Primary Antibody for ELISA, ICC - ABIN4297093
Kang, Feinleib, Knox, Ketteringham, Krauss: Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation. in Proceedings of the National Academy of Sciences of the United States of America 2003
Human Polyclonal CDON Primary Antibody for CyTOF, FACS - ABIN4899986
Cardozo, Sánchez-Arrones, Sandonis, Sánchez-Camacho, Gestri, Wilson, Guerrero, Bovolenta: Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle. in Nature communications 2015
Cdon is required to localize N-cadherin (show CDH2 Antibodies) to the cell membrane in migratory neural crest cells for directed migration.
In the developing optic vesicle, Cdon predominantly localizes to the basolateral side of neuroepithelial cells, promotes the enlargement of the neuroepithelial basal end-foot and traps Hedgehog (show SHH Antibodies) protein, thereby limiting its dispersion.
We identified a novel heterozygous nonsense CDON mutation in a case of Pituitary Stalk Interruption Syndrome who presented with neonatal hypoglycemia and cholestasis
CDO (show CDO1 Antibodies) is required for proliferation and survival of lung cancer cells via Hh signaling.
These data support the view that cell-adhesion molecule (show MCAM Antibodies)-related/downregulated by oncogenes (CDON) acts as a tumor suppressor in neuroblastomas, and that CDON is tightly regulated by miRNAs.
Single-nucleotide polymorphism in CDON is associated with biochemical recurrence in prostate cancer.
Mutations in the CDON cause holoprosencephaly. (Review)
We found that CDON is overexpressed in prostate cancer
CDON must associate with both ligand and other hedgehog (show SHH Antibodies)-receptor components, particularly PTCH1 (show PTCH1 Antibodies), for signaling to occur and disruption of the latter interactions is a mechanism of holoprosencephaly.
Hedgehog (show SHH Antibodies) proteins interact with cell adhesion molecule (show MCAM Antibodies), down-regulated by oncogenes (CDO (show CDO1 Antibodies)) and brother of CDO (BOC (show BOC Antibodies)) in a conserved manner
CDO (show CDO1 Antibodies) and BOC (show BOC Antibodies) play a role in differentiation of cells in the skeletal muscle lineage
CDO (show CDO1 Antibodies) and BOC (show BOC Antibodies) forms complexes with specific cadherins that mediate some of the promyogenic effects of cell-cell contact.
These results support a model whereby mutations in Cdon and prenatal ethanol exposure increase Septo-optic dysplasia risk through spatiotemporal perturbations in Shh (show SHH Antibodies) signaling activity.
Mutation in the Cdon gene is associated with congenital nevus development.
Study assessed the role of the Shh (show SHH Antibodies) receptor Cdon in the development of ventral tegmental area and substantia nigra pars (show EPRS Antibodies) compacta dopamine neurons. Results suggest that Cdon plays an important role in the encoding of diversity within the population of dopamine neurons of the midbrain, influencing both the development of the mesocortical dopamine pathway as well as behavioral outputs that involve this neural circuitry.
Results suggest that a promyogenic cell adhesion molecule (show MCAM Antibodies) Cdo (show CDO1 Antibodies) signaling is critical for Inward rectifier potassium channel Kir2.1 (show KCNJ2 Antibodies) activities in the induction of myogenic differentiation.
PKN2 (show PKN2 Antibodies) formed complexes with Cdo (show CDO1 Antibodies), APPL1 (show APPL1 Antibodies) and AKT (show AKT1 Antibodies) via its C-terminal region and this interaction appeared to be important for induction of AKT (show AKT1 Antibodies) activity as well as myoblast differentiation.
that Cdon participates in oligodendrocyte differentiation and myelination, most likely in the initial stages of development
Suggest that Cdo (show CDO1 Antibodies) is required for the full Shh (show SHH Antibodies) signaling activation to induce efficient dopaminergic neuron neurogenesis.
Rescue of holoprosencephaly in fetal alcohol-exposed Cdon mutant mice by reduced gene dosage of Ptch1 (show PTCH1 Antibodies).
Cx43 (show GJA1 Antibodies) physically interacts with Cdo (show CDO1 Antibodies) to form dynamic complexes during myoblast differentiation
Stim1 (show STIM1 Antibodies) protein levels were decreased in Cdo (show CDO1 Antibodies)-deficient perinatal hindlimb muscles or primary myoblasts; this correlates with defective NFATc3 (show NFATC3 Antibodies) activation in Cdo (show CDO1 Antibodies)(-/-) myoblasts upon differentiation.
This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis.
Cdon homolog (mouse)
, surface glycoprotein, Ig superfamily member
, cell adhesion molecule-related/down-regulated by oncogenes
, Cdon homolog
, immunoglobulin superfamily member
, CAM-related/down-regulated by oncogenes
, immunoglobulin superfamily member CDO
, oncogene-regulated cell adhesion molecule
, cysteine dioxygenase type 1
, cysteine dioxygenase type I