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anti-Human alpha 2 Antiplasmin Antibodies:
anti-Rat (Rattus) alpha 2 Antiplasmin Antibodies:
anti-Mouse (Murine) alpha 2 Antiplasmin Antibodies:
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Human Polyclonal alpha 2 Antiplasmin Primary Antibody for IHC (p), IHC - ABIN409115
Lee, Jackson, Christiansen, Chung, McKee: A novel plasma proteinase potentiates alpha2-antiplasmin inhibition of fibrin digestion. in Blood 2004
Show all 2 Pubmed References
Human Polyclonal alpha 2 Antiplasmin Primary Antibody for IF, WB - ABIN518963
Hayashi, Ushizawa, Hosoe, Takahashi: Differential gene expression of serine protease inhibitors in bovine ovarian follicle: possible involvement in follicular growth and atresia. in Reproductive biology and endocrinology : RB&E 2011
Human Polyclonal alpha 2 Antiplasmin Primary Antibody for IHC, IHC (p) - ABIN4352973
Kato, Nicholson, Neiman, Rantalainen, Holmes, Barrett, Uhlén, Nilsson, Spector, Schwenk: Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model. in Proteome science 2011
Data suggest that protein aggregates interact with tissue-type plasminogen activator (show PLAT Antibodies) and plasminogen (show PLG Antibodies) to efficiently generate plasmin (show PLG Antibodies); this aggregate-bound plasmin (show PLG Antibodies) is shielded from inhibition by alpha-2-antiplasmin and degrades protein aggregates to release smaller, soluble but relatively hydrophobic peptide fragments; these fragments bind to and are cytotoxic to microglia (by not vascular endothelial cells).
Higher plasma concentrations of a-2-AP and PAI-1 (show SERPINE1 Antibodies) in patients with OSA indicated that these patients had increased prothrombotic activity. OSA increases the risk of cardiovascular complications as it enhances prothrombotic activity.
alpha2AP has a profibrotic effect probably not by the action as a plasmin (show PLG Antibodies) inhibitor, and the blocking of alpha2AP exerts an antifibrotic effect in humans and mice with systemic sclerosis
Possession of the alpha2AP 407Lys allele was negatively associated with AAA (show APP Antibodies), and thus changes in alpha2AP may affect aneurysm growth and development.
Two differentially expressed proteins, alpha-1-antitrypsin (SERPINA1 (show SERPINA1 Antibodies)) and alpha-2 antiplasmin (SERPINF2) are associated with purpura fulminans.
Data suggest serum A2AP (SERPINF2) level can serve as biomarker for diabetic retinopathy; levels of A2AP (but not fibrinogen, plasminogen (show PLG Antibodies), or plasminogen activator inhibitor 1 (show SERPINE1 Antibodies)) are up-regulated in hyperglycemic type 1 diabetes with retinopathy.
Study revealed that plasmin (show PLG Antibodies) was present in tumor tissue, and that it was responsible for processing progalanin to galanin (show GAL Antibodies)(1-20) in the extracellular environment.
Data suggest that decreased amounts of alpha2-plasmin (show PLG Antibodies) inhibitor in plasma vs serum ex vivo may reflect reduced factor XIII (show UGDH Antibodies) (FXIII) in vivo; thus, plasma vs serum alpha2-plasmin (show PLG Antibodies) inhibitor may be useful diagnostic marker for severe FXIII deficiency.
When the C terminus of alpha(2)-antiplasmin was removed, the binding affinity for active site-blocked plasmin (show PLG Antibodies) remained high, suggesting additional exosite interactions between the serpin core and plasmin (show PLG Antibodies).
Truncation of monocyte chemoattractant protein 1 (show CCL2 Antibodies) by plasmin (show PLG Antibodies) promotes blood-brain barrier disruption.
After cryotherapy of the sclera, pigment epithelium-derived factor (show SERPINF1 Antibodies) levels increased 44.8% compared to untreated controlsand stayed at that level until day 14. It returned to baseline by day 21. (untreated).
the inhibitory effect of PEDF appears to be mediated via the processing of VEGF-R2 by gamma-secretase
Combination of neuroprotective factors Pedf (show SERPINF1 Antibodies) plus docosahexaenoic acid (DHA) stimulates corneal nerve regeneration. Data suggest activation of Pedfr by Pedf (show SERPINF1 Antibodies) (here, applied topically to treat corneal nerve injury) promotes regeneration of corneal nerve via up-regulation of release of DHA (here, also applied topically) and expression of specific nerve tissue/eye proteins. (Pedfr = pigment epithelium-derived factor (show SERPINF1 Antibodies) receptor)
The renoprotective effects of PEDF (show SERPINF1 Antibodies) are mediated, at least partially, by inhibition of the Wnt (show WNT2 Antibodies) pathway in kidneys.
PEDF (show SERPINF1 Antibodies) deficiency has a significant impact on retinal endothelial cell adhesion and migration through altered production of extracellular matrix and junctional proteins in response to increased oxidative stress affecting their proangiogenic activity.
PEDF (show SERPINF1 Antibodies) is a hormone-regulated negative autocrine mediator of endometrial proliferation.
These results indicate that PEDF (show SERPINF1 Antibodies) counters Wnt (show WNT2 Antibodies) signaling to allow for osteoblast differentiation and provides a mechanistic insight into how the PEDF (show SERPINF1 Antibodies) null state results in OI type VI.
Furthermore, pigment epithelium-derived factor (PEDF (show SERPINF1 Antibodies)), a secreted glycoprotein known for its anti-tumor properties, blocked Wnt3a (show WNT3A Antibodies)-directed induction of autophagy proteins. Autophagy inhibition was complemented by reciprocal regulation of the oxidative stress enzymes, superoxide dismutase 2 (SOD2 (show SOD2 Antibodies)) and catalase (show CAT Antibodies).
Study demonstrated the inhibitory effect of PEDF (show SERPINF1 Antibodies) on insulin (show INS Antibodies)-dependent molecular mechanisms of glucose homeostasis, and suggests that PEDF (show SERPINF1 Antibodies) could be a specific target in the management of metabolic disorders.
Alpha-2-Antiplasmin mediated myofibroblast formation and the development of renal fibrosis in unilateral ureteral obstruction via induction of TGF-beta (show TGFB1 Antibodies).
PEDF (show SERPINF1 Antibodies) inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids in diabetic retinopathy.
This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene.
, alpha-2-plasmin inhibitor
, serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
, serpin F2
, serine (or cysteine) proteinase inhibitor, clade F, member 2
, alpha-2 antiplasmin
, pigment epithelium derived factor
, pigment epithelium-derived factor
, serpin peptidase inhibitor, clade F, member 1
, alpha-2-PI serine protease inhibitor
, alpha 2 antiplasmin
, plasmin inhibitor alpha 2
, serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
, serine (or cysteine) proteinase inhibitor, clade F), member 1
, serine (or cysteine) proteinase inhibitor, clade F, member 1
, serpin F1
, stromal cell derived factor 3
, stromal cell-derived factor 3