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Human Polyclonal DICER1 Primary Antibody for IHC, IHC (p) - ABIN268305
Doi, Zenno, Ueda, Ohki-Hamazaki, Ui-Tei, Saigo: Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors. in Current biology : CB 2003
Show all 13 Pubmed References
Human Polyclonal DICER1 Primary Antibody for IHC, IHC (p) - ABIN4305208
Montenegro, Romero, Kim, Tarca, Draghici, Kusanovic, Kim, Lee, Erez, Gotsch, Hassan, Kim: Expression patterns of microRNAs in the chorioamniotic membranes: a role for microRNAs in human pregnancy and parturition. in The Journal of pathology 2008
Show all 6 Pubmed References
Human Polyclonal DICER1 Primary Antibody for IP, WB - ABIN438466
Tan, Garchow, Liu, Metzler, Kiriakidou: Clarifying mammalian RISC assembly in vitro. in BMC molecular biology 2011
Show all 4 Pubmed References
Human Polyclonal DICER1 Primary Antibody for ChIP, IP - ABIN577054
Wang, McAllister, Bailey, Scott, Hendley, Leach, Ghosh: Dicer is required for maintenance of adult pancreatic acinar cell identity and plays a role in Kras-driven pancreatic neoplasia. in PLoS ONE 2014
Show all 3 Pubmed References
Mammalian Monoclonal DICER1 Primary Antibody for WB - ABIN1304616
Satterlee, Beckel-Mitchener, McAllister, Procaccini, Rutter, Tyson, Chadwick: Community resources and technologies developed through the NIH Roadmap Epigenomics Program. in Methods in molecular biology (Clifton, N.J.) 2014
Show all 3 Pubmed References
Human Polyclonal DICER1 Primary Antibody for ICC, IF - ABIN438467
Huang, Chuang, Hao, Talbot, Sen, Trink, Sidransky, Ratovitski: Phospho-?Np63? is a key regulator of the cisplatin-induced microRNAome in cancer cells. in Cell death and differentiation 2011
Show all 2 Pubmed References
Human Monoclonal DICER1 Primary Antibody for ELISA, WB - ABIN525145
Chen, Li, Lin, Yang, Chien, Syu, Lo: Cleavage of Dicer protein by I7 protease during vaccinia virus infection. in PLoS ONE 2015
Human Polyclonal DICER1 Primary Antibody for WB - ABIN223376
Edinger, Coronnello, Bodnar, LaFramboise, Benos, Ho, Johnson, Butterworth, Bhalla, Labarca: Aldosterone regulates microRNAs in the cortical collecting duct to alter sodium transport. in Journal of the American Society of Nephrology : JASN 2014
Human Polyclonal DICER1 Primary Antibody for ELISA, FACS - ABIN4305211
McNamara, Andrechek, Wang, Viles, Rempel, Gilboa, Sullenger, Giangrande: Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras. in Nature biotechnology 2006
Dicer localisation is dynamic and not exclusively cytoplasmic, particularly in cells exposed to DNA damage.
Loss of Dicer1 expression is associated with ovarian tumor cells originating in the fallopian tube stroma.
Dicer is crucial for maintenance of adult dopaminergic neurons, whereas a stimulation of microrna production can promote neuronal survival.
Data show that Dicer1(Flox/-) mice histologically and genetically resemble human angiosarcoma.
These findings reveal that Dicer, through its production of mature miRNAs, plays a key role in the maintenance of monosynaptic sensory-motor circuits.
we found that the miRNA biogenesis enzyme DICER was required for the binding of the PRC2 core components EZH2 and SUZ12, and for the presence of the PRC2-mediated histone modification H3K27me3 at many bivalent genes
Lack of Dicer leads to oxidative stress, cytosolic acidification, upregulated NHE1 (show SLC9A1 Antibodies) expression and activity as well as swelling of CD4 (show CD4 Antibodies)+ T cells, functions all reversed by miR (show MLXIP Antibodies)-15b or miR (show MLXIP Antibodies)-200b.
Results show that elevated miR (show MLXIP Antibodies)-15b as an early response to Dicer depletion silenced Pim-1 (show PIM1 Antibodies) kinase resulting in mitochondrial dysfunction. Rescue experiments demonstrated that suppression of miRNA-15b induction in Dicer-deleted adult hearts result in marked amelioration of cardiac dysfunction.
Dicer1 ablation impairs Shh-induced granule neuron precursor proliferation by disrupting the expression of distinct cell cycle regulator genes that are targets of miR-17 approximately 92 cluster members. This study establishes a molecular link between miRNAs and cell cycle progression in the proliferating Granule neuron precursors during normal cerebellar development and may facilitate miRNA application in treating med...
Dicer maintains the identity and function of proprioceptive sensory neurons. Results suggest that Dicer and, most likely by extension, microRNAs are crucially important for maintaining proprioception. Additionally, this study hints at the larger question of how neurons maintain their functional and molecular specificity.
neither likely pathogenic nor pathogenic variants in DICER1 appear to play a major role in transposition of the great arteries.
first report of DICER1 mutations in pulmonary blastoma.
Decreased argonaute 2 (show EIF2C2 Antibodies) and dicer1 in peripheral blood mononuclear cells from War Veterans with post-traumatic stress disorder leads to diminished miRNA resulting in elevated inflammation.
The activation of Dicer suppressed the production of TNFalpha (show TNF Antibodies). These results suggested that Dicer can balance the production of TNFalpha (show TNF Antibodies), and thus may serve as a regulator of the immune response in patients with RA.
Dicer efficiently suppresses the replication of adenovirus via cleavage of adenovirus-encoding small RNAs.
The present study demonstrates that hypoxia-induced downregulation of Dicer serves as key mechanism in the maintenance of the hypoxic response in HCC (show FAM126A Antibodies) and that prevention of hypoxic suppression of Dicer not only alleviates hypoxia-induced upregulation of HIF1a (show HIF1A Antibodies) and HIF2a (show EPAS1 Antibodies) and other key hypoxia-responsive/HIF target genes, but also inhibits hypoxia-induced metastatic phenotypes such as EMT (show ITK Antibodies) and increased cell motility.
two cases with DICER1 mutations were found to have lung cysts preceding the diagnosis of pathogenesis of pleuropulmonary blastoma
Decreased Dicer expression was found in chronic lymphocytic leukemia patients with chromosomal deletions.
Most neoplasms in the syndrome have been shown to harbor biallelic pathogenic variants in DICER1, usually a germline loss-of-function pathogenic variant in one allele that can occur in any domain and a tumor-specific pathogenic somatic variant in exons encoding the RNase IIIb domain of the second allele
Describe familial HCC (show FAM126A Antibodies) associated with a novel DICER1 germline mutation and altered liver zonation. Familial and sporadic HCCs (show HCCS Antibodies) carrying DICER1 mutations are associated with CTNNB1 (show CTNNB1 Antibodies) mutation and characterized by a reduced expression of specific mature miRNAs.
Diminished androgen action during gestation induces changes in Dicer1 mRNA expression.
The primary cDNA sequence of porcine Dicer was determined, and its expression in porcine oocytes and early stage embryos was confirmed.
Studied Dicer gene expression during early bovine embryo development.An increase in Dicer expression was detected in the mature oocytes sampled (P<0.05), implying that gene repression occurs during meiosis II.
Dynamic miRNA expression patterns during retinal regeneration in zebrafish: reduced dicer or miRNA expression suppresses proliferation of Muller glia-derived neuronal progenitor cells
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants.
Dicer1, Dcr-1 homolog
, endoribonuclease Dicer
, dicer 1, ribonuclease type III
, double-stranded RNA-specific endoribonuclease type III
, double-strand-specific ribonuclease mDCR-1
, dicer 1, double-stranded RNA-specific endoribonuclease
, helicase MOI
, helicase with RNAse motif
, dsRNA-specific ribonuclease