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Human Polyclonal DICER1 Primary Antibody for IHC, IHC (p) - ABIN268305
Doi, Zenno, Ueda, Ohki-Hamazaki, Ui-Tei, Saigo: Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors. in Current biology : CB 2003
Show all 12 Pubmed References
Human Polyclonal DICER1 Primary Antibody for IHC, IHC (p) - ABIN4305208
Montenegro, Romero, Kim, Tarca, Draghici, Kusanovic, Kim, Lee, Erez, Gotsch, Hassan, Kim: Expression patterns of microRNAs in the chorioamniotic membranes: a role for microRNAs in human pregnancy and parturition. in The Journal of pathology 2008
Show all 6 Pubmed References
Human Polyclonal DICER1 Primary Antibody for ChIP, IP - ABIN577054
Wang, McAllister, Bailey, Scott, Hendley, Leach, Ghosh: Dicer is required for maintenance of adult pancreatic acinar cell identity and plays a role in Kras-driven pancreatic neoplasia. in PLoS ONE 2014
Show all 3 Pubmed References
Mammalian Monoclonal DICER1 Primary Antibody for WB - ABIN1304616
Satterlee, Beckel-Mitchener, McAllister, Procaccini, Rutter, Tyson, Chadwick: Community resources and technologies developed through the NIH Roadmap Epigenomics Program. in Methods in molecular biology (Clifton, N.J.) 2014
Show all 3 Pubmed References
Human Polyclonal DICER1 Primary Antibody for IP, WB - ABIN438466
Tan, Garchow, Liu, Metzler, Kiriakidou: Clarifying mammalian RISC assembly in vitro. in BMC molecular biology 2011
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Human Polyclonal DICER1 Primary Antibody for ICC, IF - ABIN438467
Huang, Chuang, Hao, Talbot, Sen, Trink, Sidransky, Ratovitski: Phospho-?Np63? is a key regulator of the cisplatin-induced microRNAome in cancer cells. in Cell death and differentiation 2011
Show all 2 Pubmed References
Human Monoclonal DICER1 Primary Antibody for ELISA, WB - ABIN525145
Chen, Li, Lin, Yang, Chien, Syu, Lo: Cleavage of Dicer protein by I7 protease during vaccinia virus infection. in PLoS ONE 2015
Human Polyclonal DICER1 Primary Antibody for ELISA, FACS - ABIN4305211
McNamara, Andrechek, Wang, Viles, Rempel, Gilboa, Sullenger, Giangrande: Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras. in Nature biotechnology 2006
Human Polyclonal DICER1 Primary Antibody for WB - ABIN223376
Edinger, Coronnello, Bodnar, LaFramboise, Benos, Ho, Johnson, Butterworth, Bhalla, Labarca: Aldosterone regulates microRNAs in the cortical collecting duct to alter sodium transport. in Journal of the American Society of Nephrology : JASN 2014
Data show that Dicer1(Flox/-) mice histologically and genetically resemble human angiosarcoma.
These findings reveal that Dicer, through its production of mature miRNAs, plays a key role in the maintenance of monosynaptic sensory-motor circuits.
we found that the miRNA biogenesis enzyme DICER was required for the binding of the PRC2 core components EZH2 and SUZ12, and for the presence of the PRC2-mediated histone modification H3K27me3 at many bivalent genes
Lack of Dicer leads to oxidative stress, cytosolic acidification, upregulated NHE1 (show SLC9A1 Antibodies) expression and activity as well as swelling of CD4 (show CD4 Antibodies)+ T cells, functions all reversed by miR (show MLXIP Antibodies)-15b or miR (show MLXIP Antibodies)-200b.
Results show that elevated miR (show MLXIP Antibodies)-15b as an early response to Dicer depletion silenced Pim-1 (show PIM1 Antibodies) kinase resulting in mitochondrial dysfunction. Rescue experiments demonstrated that suppression of miRNA-15b induction in Dicer-deleted adult hearts result in marked amelioration of cardiac dysfunction.
Dicer1 ablation impairs Shh-induced granule neuron precursor proliferation by disrupting the expression of distinct cell cycle regulator genes that are targets of miR-17 approximately 92 cluster members. This study establishes a molecular link between miRNAs and cell cycle progression in the proliferating Granule neuron precursors during normal cerebellar development and may facilitate miRNA application in treating med...
Dicer maintains the identity and function of proprioceptive sensory neurons. Results suggest that Dicer and, most likely by extension, microRNAs are crucially important for maintaining proprioception. Additionally, this study hints at the larger question of how neurons maintain their functional and molecular specificity.
this study shows that Dicer deficiency differentially impacts microglia of the developing and adult brain
this study shows that deletion Dicer1 specifically in Th17 cells protected mice from experimental autoimmune encephalomyelitis
Dicer expression in smooth muscle cells plays an essential role in vascular repair by generating anti-proliferative miRNAs.
Study identified nonsense germ-line and missense somatic mutations in DICER1 causing a truncated protein at the IIIb domain level that segregate within a family affected with Dicer1 syndrome.
Data suggest that DICER plays a pleiotropic role in glioma stem-like cells, modulating the growth properties of glioma tumors arising from these cells and their response to DNA damage-inducing agents, leading to formation of larger tumors that are more sensitive to radiation.
validate the results of the aforementioned animal study and demonstrate downregulation of DICER1 gene and abnormal miRNA profile in myelodysplastic syndrome
We found that inhibition of DICER processing of miR (show MLXIP Antibodies)-544 through the use of a small molecule abolished miR (show MLXIP Antibodies)-544 function in regulating adaptation of breast cancer cells to hypoxic stress.
Data show that the expression of miRNAs and Dicer1 were downregulated in cells lines expressing HTLV-I HBZ (show HBZ Antibodies) protein (HBZ (show HBZ Antibodies)) as well as in fresh CD4 (show CD4 Antibodies) (+) cells from acute adult T cell Leukemia (ATL) patients.
the DICER rs1057035 TT genotype and DROSHA (show DROSHA Antibodies) rs644236 CC genotype were associated with the development of GD and the differentiation between GD and HD, respectively. The expression levels of DICER and DROSHA (show DROSHA Antibodies) genes were low in AITD and differed depending on the intractability of GD and the severity of HD, respectively.
Data indicate that Dicer1 can function as a traditional loss-of-function tumor suppressor gene.
For the first time, we establish macrocephaly as a common finding in the DICER1 syndrome. Like some other tumor-predisposition disorders, macrocephaly may be a useful, albeit a subtle, clinical clue to the DICER1 syndrome diagnosis
The increased miR (show MLXIP Antibodies)-122 levels were associated with poor metastasis-free survival in ccRCC patients with localized disease. Dicer was validated as a direct functional target of miR (show MLXIP Antibodies)-122. Overexpression of miR (show MLXIP Antibodies)-122 promoted migration and invasion of ccRCC cells in vitro and metastatic behavior of ccRCC cells in vivo.
Nearly all (36/37) SLCTs and 4/4 GAB (show A1BG Antibodies) tested had a DICER1 mutation in an RNase IIIb domain hotspot; approximately half of these individuals had a predisposing germline DICER1 mutation.
Diminished androgen action during gestation induces changes in Dicer1 mRNA expression.
The primary cDNA sequence of porcine Dicer was determined, and its expression in porcine oocytes and early stage embryos was confirmed.
Studied Dicer gene expression during early bovine embryo development.An increase in Dicer expression was detected in the mature oocytes sampled (P<0.05), implying that gene repression occurs during meiosis II.
Dynamic miRNA expression patterns during retinal regeneration in zebrafish: reduced dicer or miRNA expression suppresses proliferation of Muller glia-derived neuronal progenitor cells
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants.
Dicer1, Dcr-1 homolog
, endoribonuclease Dicer
, dicer 1, ribonuclease type III
, double-stranded RNA-specific endoribonuclease type III
, double-strand-specific ribonuclease mDCR-1
, dicer 1, double-stranded RNA-specific endoribonuclease
, helicase MOI
, helicase with RNAse motif
, dsRNA-specific ribonuclease