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anti-Immunoglobulin D (IgD) secondary antibodies

Immunoglobulin D (IgD)

IgD (IgD) is a monomeric antibody isotype that is expressed in the plasma membranes of immature B-lymphocytes. IgD is also produced in a secreted form that is found in small amounts in blood serum. Secreted IgD is made up of two heavy chains of the delta class, and two light chains.

IgD's function has long been a conundrum and is still incompletely understood. IgD is present in species ranging from fish to human (probably with the exception of birds), indicating that IgD has been preserved since its ancient origins which suggests that IgD has important immunological functions.

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In antigen-based serological SARS-CoV-2 tests secondary antibodies against human IgG or human IgM are used as capture antibodies: anti-Human IgG Antibodies, anti-Human IgM Antibodies

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It is known that IgD signals for B cells to be activated in order for them to participate in the immune defence. Apparently IgM and IgD share this role, with IgM being expressed sooner in the life-cycle of B-cells than IgD. It is not well understood what the functional difference of IgM and IgD on B cells is. Knock-out mice models have not yielded any major intrinsic defects.

In fact, heavy chains of IgM and IgD are encoded by a common transcription unit. IgM-/- mice show normal B-cell development and maturation, with IgD replacing membrane-bound and secretory IgM. These data suggest that IgD is largely able to substitute for IgM functions in B-cells.

IgD apparently is also able to bind to basophils and mast cells and activate these cells to produce antimicrobial factors that are functional in respiratory immune defence in humans.

IgD secondary antibodies

Reactivity Host Unconj. AP Biotin FITC HRP PE
Mouse Rat ABIN135030 - ABIN135032 ABIN5631078 ABIN135031 ABIN135033
Human Mouse ABIN135614 ABIN135615 ABIN135617 ABIN135623 ABIN135616 ABIN2749204
Chicken Mouse ABIN135550 - ABIN135552 ABIN135551 - ABIN135553

Learn more about other secondary antibody-types

David Kitz Kramer
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