anti-Immunoglobulin D (IgD) Secondary Antibodies
IgD (IgD) is a monomeric antibody isotype that is expressed in the plasma membranes of immature B-lymphocytes. IgD is also produced in a secreted form that is found in small amounts in blood serum. Secreted IgD is made up of two heavy chains of the delta class, and two light chains. IgD's function has long been a conundrum and is still incompletely understood. IgD is present in species ranging from fish to human (probably with the exception of birds), indicating that IgD has been preserved since its ancient origins which suggests that IgD has important immunological functions.
It is known that IgD signals for B cells to be activated in order for them to participate in the immune defence. Apparently IgM and IgD share this role, with IgM being expressed sooner in the life-cycle of B-cells than IgD. It is not well understood what the functional difference of IgM and IgD on B cells is. Knock-out mice models have not yielded any major intrinsic defects. In fact, heavy chains of IgM and IgD are encoded by a common transcription unit. IgM-/- mice show normal B-cell development and maturation, with IgD replacing membrane-bound and secretory IgM. These data suggest that IgD is largely able to substitute for IgM functions in B-cells. IgD apparently is also able to bind to basophils and mast cells and activate these cells to produce antimicrobial factors that are functional in respiratory immune defence in humans.
IgD Secondary Antibodies
anti-Human IgD Secondaries
Product
Conjugate
Application
Cat. No.
Quantity
Conjugate
ApplicationFACS, ELISA, WB
Cat. No.ABIN376896
Quantity1 mg
ConjugateBiotin
ApplicationFACS, ELISA, WB
Cat. No.ABIN375950
Quantity1 mg
ConjugateFITC
ApplicationFACS, ELISA
Cat. No.ABIN376130
Quantity1 mg
ConjugatePE
ApplicationFACS, ELISA
Cat. No.ABIN376508
Quantity0.5 mg
ConjugateTRITC
ApplicationFACS, ELISA
Cat. No.ABIN376758
Quantity1 mg
ConjugateHRP
ApplicationELISA, WB
Cat. No.ABIN376267
Quantity1 mL
ConjugateAlkaline Phosphatase (AP)
ApplicationELISA, WB
Cat. No.ABIN375680
Quantity1 mL
ConjugateTexas Red (TR)
ApplicationFACS, ELISA
Cat. No.ABIN376793
Quantity1 mg
ConjugateAPC
ApplicationFACS
Cat. No.ABIN6240825
Quantity100 tests
anti-Mouse IgD Secondaries
Product
Conjugate
Application
Cat. No.
Quantity
Conjugate
ApplicationFACS
Cat. No.ABIN135030
Quantity0.5 mg
ConjugateFITC
ApplicationFACS
Cat. No.ABIN135031
Quantity0.5 mg
ConjugateBiotin
ApplicationFACS
Cat. No.ABIN135032
Quantity0.5 mg
ConjugatePE
ApplicationFACS
Cat. No.ABIN135033
Quantity0.1 mg
ConjugateTRITC
ApplicationELISA, ICC, IF, IHC (fro)
Cat. No.ABIN458378
Quantity1 mL
anti-Rat IgD Secondaries
Product
Conjugate
Application
Cat. No.
Quantity
Conjugate
ApplicationFACS, IHC (fro)
Cat. No.ABIN118428
Quantity0.25 mg
ConjugateFITC
ApplicationIHC (fro), IF, IP, ELISA, WB
Cat. No.ABIN289160
Quantity1 mg
ConjugateBiotin
ApplicationELISA
Cat. No.ABIN2474274
Quantity0.5 mg
Learn more about other secondary antibody types
David Kitz Kramer
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