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anti-Human GRIN2B Antibodies:
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Mammalian Monoclonal GRIN2B Primary Antibody for ISt, IHC - ABIN1304683
Mellone, Pelucchi, Alberti, Genazzani, Di Luca, Gardoni: Zinc transporter-1: a novel NMDA receptor-binding protein at the postsynaptic density. in Journal of neurochemistry 2015
Show all 58 Pubmed References
Mammalian Monoclonal GRIN2B Primary Antibody for ISt, IHC - ABIN1304684
DiBattista, Dumanis, Song, Bu, Weeber, Rebeck, Hoe: Very low density lipoprotein receptor regulates dendritic spine formation in a RasGRF1/CaMKII dependent manner. in Biochimica et biophysica acta 2015
Show all 35 Pubmed References
Rat (Rattus) Polyclonal GRIN2B Primary Antibody for WB - ABIN152526
Li, El-Hayek, Liu, Chen, Gomez, Wu, Ning, Li, Chang, Zhang, Wang, Hu, Wan: Direct-current electrical field guides neuronal stem/progenitor cell migration. in Stem cells (Dayton, Ohio) 2008
Show all 5 Pubmed References
Polyclonal GRIN2B Primary Antibody for IF - ABIN4948295
Babb, Ying, Mikuni, Nishiyama, Drazba, Bingaman, Wyllie, Wylie, Yacubova: Brain plasticity and cellular mechanisms of epileptogenesis in human and experimental cortical dysplasia. in Epilepsia 2000
Show all 3 Pubmed References
Rat (Rattus) GRIN2B Primary Antibody for ELISA, WB - ABIN1742592
Strack, McNeill, Colbran: Mechanism and regulation of calcium/calmodulin-dependent protein kinase II targeting to the NR2B subunit of the N-methyl-D-aspartate receptor. in The Journal of biological chemistry 2000
Show all 2 Pubmed References
Human Polyclonal GRIN2B Primary Antibody for ELISA, WB - ABIN251562
Arning, Kraus, Valentin, Saft, Andrich, Epplen: NR2A and NR2B receptor gene variations modify age at onset in Huntington disease. in Neurogenetics 2005
Show all 2 Pubmed References
Human Polyclonal GRIN2B Primary Antibody for IF (p), IHC (p) - ABIN744368
Zhao, Li, Wei, Savage, Zhou, Ma: Ketamine administered to pregnant rats in the second trimester causes long-lasting behavioral disorders in offspring. in Neurobiology of disease 2014
Show all 2 Pubmed References
Human Polyclonal GRIN2B Primary Antibody for IHC, ELISA - ABIN1584927
Xie, Yang, Gu, Zheng, Sun, Liang, Bo, Ma: Senegenin attenuates hepatic ischemia-reperfusion induced cognitive dysfunction by increasing hippocampal NR2B expression in rats. in PLoS ONE 2012
Human Polyclonal GRIN2B Primary Antibody for IF (p), IHC (p) - ABIN801243
Wen, Fu, Wu, Si, Xie, Dan, Zhan, Shi: Inhibition of Calcineurin A by FK506 Suppresses Seizures and Reduces the Expression of GluN2B in Membrane Fraction. in Neurochemical research 2017
Rat (Rattus) Polyclonal GRIN2B Primary Antibody for IHC, WB - ABIN152632
Berrout, Isokawa: Ghrelin upregulates the phosphorylation of the GluN2B subunit of the NMDA receptor by activating GHSR1a and Fyn in the rat hippocampus. in Brain research 1970
The results suggest that the GRIN2B gene may modify the linguistic processes involved in the retrieval of information from the mental lexicon on the basis of semantic traits and, moreover, contribute to the variability of clinical symptoms of impairment of abstract thinking in patients with schizophrenia.
It is this DAPK1 (show DAPK1 Antibodies)-NR2B interaction that arbitrates the pathological processes like apoptosis, necrosis, and autophagy of neuronal cells observed in stroke injury, hence we aimed to inhibit this vital interaction to prevent neuronal damage.
Five rare missense mutations in the GRIN2B gene are not associated with schizophrenia or autism spectrum disorder in a Japanese population.
NR4A1 (show NR4A1 Antibodies) knockdown partly decreased surface NR2B by promoting NR2B internalization.
This review showed that GRIN2B associate with Obsessive-compulsive disorder.
GRIN2B polymorphism was associated with a twofold increase in odds of a Suicide Attempts in Alcohol-dependent individuals.
GRIN2B encephalopathy is also frequently associated with movement disorder, cortical visual impairment and malformation of cortical development revealing novel phenotypic consequences of channelopathies.
mutations of the human NMDAR (show GRIN1 Antibodies) were investigated and studied their consequences with kinetic modelling and electrophysiology.
The polymorphisms in HTR2A and GRIN2B were significantly associated with increased risk of chronic obstructive pulmonary disease.
In vitro DNA-binding and reporter gene assays of different allele combinations in transfected cells showed that the A allele was a gain-of-function variant associated with increasing GRIN2B mRNA levels
chronic KOR (show OPRK1 Antibodies) activation increased phosphorylation of NR2B subunit of NMDA at tyrosine 1472 (pNR2B NMDA) in the hippocampus, but not in the cortex.
Study generated the Cdkl5 (show CDKL5 Antibodies) KO mice, and identified hyperexcitability in response to NMDA and postsynaptic overaccumulation of GluN2B-containing NMDARs in the hippocampus. The GluN2B-selective antagonist ifenprodil abrogated the NMDA-induced hyperexcitability of Cdkl5 (show CDKL5 Antibodies) KO mice. These data indicate that CDKL5 (show CDKL5 Antibodies) plays an important role in controlling postsynaptic localization of the GluN2B-SAP102 (show DLG3 Antibodies) complex in the hippocampus.
APP (show APP Antibodies) intracellular domain increase in mature neurons, as reported in Alzheimer's disease, alters synaptic NMDAR (show GRIN1 Antibodies) composition to an immature-like GluN2B-rich profile. This disrupts synaptic signal integration, via over-activation of SK channels, and synapse plasticity.
The induction of a conditional forebrain-specific haploinsufficiency of GluN2B in transgenic model mice reverses the pathophysiological changes in hippocampal synaptic plasticity in a mouse model of Alzheimer's disease (AD). These results provide further evidence for the involvement of the glutamatergic system in AD pathology and emphasize the GluN2B subunit as a potential target for AD treatment.
activity-based anorexia resilience, quantified as suppression of hyperactivity, correlated strongly with reserve pools of NR2A (show GRIN2A Antibodies)-NMDA receptors in spine cytoplasm
Negative regulation of REST on NR2B in spinal cord takes part in the exacerbation of bone cancer pain.
results demonstrated that phosphorylation level of S1284 in GluN2B was regulated by acute stress
study are the first to demonstrate that phosphorylation of GluN2B subunit at Tyr1472 is important for trigeminal transmission of itch and suggest that the NMDA receptor activation occurs upstream of the receptor of gastrin-releasing peptide (GRP)-GRP (show GRP Antibodies) receptor pathway
GluN2B gene deletion mice consumed significantly less alcohol, than non-mutant controls.
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain.
NMDA type glutamate receptor
, N-methyl D-aspartate receptor subtype 2B
, N-methyl-D-aspartate receptor subunit 2B
, glutamate [NMDA] receptor subunit epsilon-2
, glutamate receptor ionotropic, NMDA 2B
, N-methyl-D-aspartate receptor subunit 3
, glutamate receptor subunit epsilon-2
, glutamate receptor, ionotropic, NMDA2B
, N-methyl-D-aspartate receptor subunit NR2B
, N-methyl D-aspartate receptor 2B