Browse our anti-Tumor Protein, Translationally-Controlled 1 (TPT1) Antibodies

Human Tumor Protein, Translationally-Controlled 1 (TPT1) interaction partners

1. The cells knocked down for TCTP show diminished invasiveness and migration under TGF-beta1 (show TGFB1 Antibodies) treatment. TGF-beta1 (show TGFB1 Antibodies) dependent TCTP expression is required for epithelial to mesenchymal transition in cells.

2. that TPT1 knockdown altered the BECN1 (show BECN1 Antibodies) interactome, a representative MTOR (show FRAP1 Antibodies)-independent pathway, to stimulate autophagosome formation

3. Transfection with TCTP-Lipid modified antisense oligonucleotides led to rapid and prolonged internalization via macropinocytosis, TCTP downregulation and significant decreased cell viability in in castration-resistant prostate cancer cells.

4. extracellular TCTP has a role as a promoter of colorectal cancer progression and liver metastases via Cdc42 (show CDC42 Antibodies)/JNK (show MAPK8 Antibodies)/MMP9 (show MMP9 Antibodies) activation

5. The structure of human HRF (hHRF) was solved in 2 new crystal forms, one at the highest resolution (1.4A) yet reported. The high resolution hHRF structure reveals a disulphide-linked dimer, in which the 2 molecules are closely associated and provides a model for the role of HRF in mast cell activation.

6. analyzed the interactome of TCTP in HeLa cells by coimmunoprecipitation (IP) and mass spectrometry (MS). Results not only reveal a large number of TCTP-associated proteins that possess pleiotropic functions, but also provide novel insights into the molecular mechanisms of TCTP in tumorigenesis

7. Fortilin directly interacts with the cytoplasmic domain of IRE1alpha, inhibits both kinase and endoribonuclease (RNase) activities of this stress sensor, and protects cells against apoptotic cell death at both cellular and whole animal levels.

8. These findings provide novel data on the role and regulation of TCTP in skeletal muscle in vivo.

9. TCTP may thus contribute to the development of anti-cancer drug resistance.

10. The findings suggest that the synergistic actions of Histamine Releasing Factor and Histamine Releasing Factor-reactive IgE may play important roles in the pathogenesis of Chronic Urticaria.

Mouse (Murine) Tumor Protein, Translationally-Controlled 1 (TPT1) interaction partners

1. that TPT1 knockdown altered the BECN1 (show BECN1 Antibodies) interactome, a representative MTOR (show FRAP1 Antibodies)-independent pathway, to stimulate autophagosome formation

2. The first crystal structure of murine HRF to 4.0A resolution, reveals a conserved fold. A model for the role of murine HRF in mast cell activation was created based on the human HRF structure.

3. Fortilin directly interacts with the cytoplasmic domain of IRE1alpha, inhibits both kinase and endoribonuclease (RNase) activities of this stress sensor, and protects cells against apoptotic cell death at both cellular and whole animal levels.

4. TCTP-mediated spindle dynamics play a key role in maintaining oocyte quality during postovulatory aging. Overexpression of TCTP is sufficient to prevent aging-associated abnormalities in mouse oocytes.

5. Leads to the enhanced and previously un-described interaction of RACK1 (show GNB2L1 Antibodies) and TCTP.

6. These data suggest the presence of a novel oxidative-stress-handling pathway where the anti-p53 (show TP53 Antibodies) molecule fortilin augments the peroxidase PRX1 (show PRDX1 Antibodies) by protecting it against degradation and inactivation of the enzyme.

7. results demonstrate that TCTP is a microtubule-associating protein required to regulate spindle microtubule dynamics during meiotic maturation in mouse oocytes.

8. TCTP over-expression-induced RhoA (show RHOA Antibodies) activation indicates that silencing of cellular TCTP may offer therapeutic approaches for the regulation of hypertension by inhibiting RhoA (show RHOA Antibodies)/Rho kinase (show ROCK2 Antibodies) pathway and modulating vascular contractility.

9. osteoclastogenic activity of translationally-controlled tumor protein (TCTP) with reciprocal repression of p21 (show D4S234E Antibodies)

10. TPT1 is a p53 (show TP53 Antibodies) target gene that promotes cell survival.

Cow (Bovine) Tumor Protein, Translationally-Controlled 1 (TPT1) interaction partners

1. pretreatment of donor cells with phosphorylated TCTP peptide has a beneficial effect on the potential of bovine somatic cell nuclei to develop into normal cloned calves.

Pig (Porcine) Tumor Protein, Translationally-Controlled 1 (TPT1) interaction partners

1. A 'Y' transition single feature polymorphism in TCTP between Meishan and white composite swine breeds was identified by expression profiling using the in silico procedure Click-'N-SNP.

2. This work describes the cloning and structural analysis of a Tpt1 cDNA coding for the porcine translationally controlled tumor protein (TCTP) molecule and its expression in porcine cells and tissues.

Xenopus laevis Tumor Protein, Translationally-Controlled 1 (TPT1) interaction partners

1. Tctp supports the development of the retinotectal projection via its regulation of pro-survival signalling and axonal mitochondrial homeostasis, and establish a novel and fundamental role for Tctp in vertebrate neural circuitry assembly.

2. Tpt1 activates transcription of oct4 and nanog in transplanted somatic nuclei.

Arabidopsis thaliana Tumor Protein, Translationally-Controlled 1 (TPT1) interaction partners

1. TCTP has molecular properties similar to animal TCTPs, such as tubulin (show TUBB Antibodies)- and calcium-binding, and that it functions in ABA-mediated stomatal movement, in addition to regulating the growth of plants.

2. data support a role of plant AtTCTP as a positive regulator of mitotic growth by specifically controlling the duration of the cell cycle.

3. The results identify TCTP as an important regulator of growth in plants and imply a function of plant TCTP as a mediator of TOR activity similar to that known in nonplant systems.

Fruit Fly (Drosophila melanogaster) Tumor Protein, Translationally-Controlled 1 (TPT1) interaction partners

1. TCTP may promote the progression of epithelial ovarian cancer and reduce the sensitiveness of HO8910 cells to cisplatin.

2. TCTP has a role in regulating ATM (show ATM Antibodies) activity to control genome stability and organ development in Drosophila melanogaster

3. plant AtTCTP can fully rescue cell proliferation defects in Drosophila loss of function for dTCTP

4. Our studies identify TCTP as a direct regulator of Rheb (show RHEB Antibodies) and a potential therapeutic target for tuberous sclerosis disease.

5. Drosophila TCTP (dTCTP) displays GEF (show SLC2A4RG Antibodies) activity to Rheb (show RHEB Antibodies) and is essential for Rheb (show RHEB Antibodies) activation in organ growth

Silk Worm Tumor Protein, Translationally-Controlled 1 (TPT1) interaction partners

1. BmTCTP as a dual-functional protein involved in both the cellular and the humoral immune response of the silkworm