RFWD3 Proteins
(Ring Finger and WD Repeat Domain 3 (RFWD3))
E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair.
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5 results
RFWD3
Origin: Human
Host: Escherichia coli (E. coli)
Recombinant
ELISA, SDS, WB
custom-made
RFWD3
Origin: Mouse
Host: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
ELISA, SDS, WB
custom-made
RFWD3
Origin: Human
Host: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
ELISA, SDS, WB
Aliases for RFWD3 Proteins
ring finger and WD repeat domain 3 (Rfwd3) Proteinsring finger and WD repeat domain 3 (RFWD3) Proteins
BC027246 Proteins
RFWD3 Proteins
RGD1305243 Proteins
RNF201 Proteins
Did you look for something else?
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