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anti-Human CELF1 Antibodies:
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Cow (Bovine) Monoclonal CELF1 Primary Antibody for FACS, GS - ABIN152357
Kress, Gautier-Courteille, Osborne, Babinet, Paillard: Inactivation of CUG-BP1/CELF1 causes growth, viability, and spermatogenesis defects in mice. in Molecular and cellular biology 2007
Show all 11 Pubmed References
Human Polyclonal CELF1 Primary Antibody for IHC - ABIN965947
Timchenko, Miller, Timchenko, DeVore, Datar, Lin, Roberts, Caskey, Swanson: Identification of a (CUG)n triplet repeat RNA-binding protein and its expression in myotonic dystrophy. in Nucleic acids research 1997
Show all 7 Pubmed References
Human Polyclonal CELF1 Primary Antibody for IHC - ABIN965946
Good, Chen, Warner, Herring: A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator. in The Journal of biological chemistry 2000
Show all 7 Pubmed References
These data present an 11 (show DCAF7 Antibodies)-component genetic pathway, invisible to transcriptional profiling approaches, in which the CELF1 protein functions as a central node controlling translational activation of genes driving EMT (show ITK Antibodies) and ultimately tumour progression.
High CELF1 expression is associated with aberrant splicing in Type 1 diabetes.
CELF1 globally regulates the alternative splicing.
Findings indicate that IGF2R (show IGF2R Antibodies) expression is controlled posttranscriptionally by two factors that associate with Igf2r (show IGF2R Antibodies) mRNA and suggest that miR (show MLXIP Antibodies)-195 and CUGBP1 dampen IGF signaling by inhibiting IGF2R (show IGF2R Antibodies) translation.
In the course of these studies, we found that RNA binding protein (show PTBP1 Antibodies) CUGBP1 is a new tumor suppressor protein (show TP53 Antibodies) which is reduced in all HBL (show LGALS1 Antibodies) samples. Therefore, we generated CUGBP1 KO mice and examined HBL (show LGALS1 Antibodies) signatures in the liver of these mice. Micro-array studies revealed that the HBL (show LGALS1 Antibodies)-specific molecular signature is developed in livers of CUGBP1 KO mice at very early ages
Results show that CELF1 is a potential target of TUG1 interaction and could be negatively regulated by TUG1 RNA.
CUG-binding protein 1 regulates HSC (show FUT1 Antibodies) activation and liver fibrogenesis.
High expression of CUGBP1 is associated with recurrence in lung adenocarcinoma.
CUG-BP1 affected the calcium release activity in single myofibers and the extent of atrophy was significantly reduced upon gene silencing of CUG-BP1 in atrophic muscle.
these data provided a comprehensive view of the CELF1 mRNA regulatory network in oral cancer
this study shows that the absence of Celf1 causes neonatal cardiac dysfunction and transcriptome changes
Results found that the blood level of CUGBP1 in mice was decreased during the progression of acute myocardial infarction (AMI (show CFD Antibodies)) and demonstrate that CUGBP1 is functionally important in AMI (show CFD Antibodies). This finding reveals the roles of CUGBP1 in the heart not only during development but also in cardiac disease.
Increased CELF1 expression down-regulates Cx43 (show GJA1 Antibodies) mRNA level in the dilated cardiomyopathy heart.
lncBATE10 can decoy Celf1 from Pgc1alpha, thereby protecting Pgc1alpha mRNA from repression by Celf1
Study concludes that CUGBP1 is a critical regulator of insulin (show INS Antibodies) secretion via activating PDE3B (show PDE3B Antibodies).
the oncoprotein gankyrin (Gank (show PSMD10 Antibodies)) preferentially binds to and triggers degradation of dephosphorylated CUGBP1 (de-ph-S302-CUGBP1) or S302A mutant CUGBP1.
Our studies support the existence of an RNA regulon containing Signal Recognition Particle mRNAs that is controlled by CELF1. One implication is that altered function of CELF1 in myotonic dystrophy may contribute to changes in the extracellular matrix of affected muscle through defects in secretion
CELF1 downregulates Cyp19a1 (Aromatase (show CYP19A1 Antibodies)) posttranscriptionally to achieve high concentrations of testosterone compatible with spermiogenesis completion.
developmental stage-specific compatibility of CELF (show CEBPD Antibodies)-dependent splice variants dictates their effects on cardiac health and function
Differential expression of CELF1 in development plays a role in alternative splicing of vesicular trafficking genes in postnatal heart development.
Results therefore suggest that Celf1 regulates proper organogenesis of endoderm-derived tissues by regulating the expression of such targets.
Celf1-dependent fine-tuning of dmrt2a (show DMRT2 Antibodies) expression is essential for generating bilateral symmetry of somites and left-right asymmetric patterning during zebrafish development.
not only mRNA but also protein of brul is localized to the zebrafish germ plasm at the ends of the cleavage furrows
This "target protector and rescue assay" demonstrates that the phenotypic defects associated with CUGBP1 inactivation in Xenopus are essentially due to the deregulation of Su(H (show RBPJ Antibodies)) mRNA.
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms.
CUG triplet repeat, RNA binding protein 1
, CUGBP Elav-like family member 1
, 50 kDa nuclear polyadenylated RNA-binding protein
, CUG RNA-binding protein
, CUG triplet repeat RNA-binding protein 1
, CUG triplet repeat, RNA-binding protein 1
, CUG-BP- and ETR-3-like factor 1
, EDEN-BP homolog
, RNA-binding protein BRUNOL-2
, bruno-like 2
, bruno-like protein 2
, deadenylation factor CUG-BP
, embryo deadenylation element binding protein
, embryo deadenylation element-binding protein homolog
, nuclear polyadenylated RNA-binding protein, 50-kD
, brain protein F41
, deadenylation factor EDEN-BP
, EDEN-BP/Bruno-like protein
, CUG triplet repeat RNA-binding protein 1-A
, CUG-BP- and ETR-3-like factor 1-A
, CUGBP Elav-like family member 1-A
, RNA-binding protein BRUNOL-2-A
, bruno-like protein 2-A
, embryo deadenylation element-binding protein A