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This is the first study to link SLC1A3 (show SLC1A3 Proteins) and EPHB2 to clinically relevant vertebral osteoporosis phenotypes.
Data show that EPHB2 predicted poor breast cancer survival and EPHB2 protein expression has also prognostic value depending on cell localization.
showed that patients with SSc (show CYP11A1 Proteins) or SLE have AAb against EphB2, a protein involved in angiogenesis, and THEX1 (show ERI1 Proteins), a 3'-5' exoribonuclease involved in histone mRNA degradation. We have further identified a peptide from EphB2 as a specific and sensitive tool for SLE diagnosis
show that expression of EPHB2 and SNAIL1 (show SNAI1 Proteins) - an inducer of epithelial-mesenchymal transition (EMT (show ITK Proteins)) - is anti-correlated in colorectal cancer cell lines and tumors
Tiam2 (show TIAM2 Proteins)/Rac (show AKT1 Proteins) are key components of EphB2 trans-endocytosis and are important for cell repulsion.
High expression of junctional adhesion molecule-A (show F11R Proteins) and EphB2 can predict poor overall survival and high mortality rate, and EphB2 is an independent prognostic biomarker in lung adenocarcinoma patients.
Data show that activation of EphB2 receptor kinase arrests tau protein hyperphosphorylation through phosphatidylinositol 3-kinase (PI3K)/Akt protein-mediated glycogen synthase kinase-3beta (GSK-3beta) inhibition.
Expression of the Receptor Tyrosine Kinase (show RET Proteins) EphB2 on Dendritic Cells Is Modulated by Toll (show TLR4 Proteins)-Like Receptor Ligation but Is Not Required for T Cell Activation
Myosin 1 functions as an effector of EphB2/ephrinB signaling, controls cell morphology, and thereby cell repulsion.
EphB2 activation is required for ependymoma development as well as it inhibits differentiation and promotes proliferation of the transformed cell.
Overexpression of EphB2 also rescued the ADDLs-induced depletion of the expression of EphB2 and GluN2B (show GRIN2B Proteins)-containing NMDA receptors trafficking in cultured hippocampal neurons.
ephrin B3 (show EFNB3 Proteins)/EphB2 are obvious candidates for driving the Syk (show SYK Proteins)-dependent repulsive response.
The results of this study indicated that the decrease in spine density in the mPFC was associated with susceptibility to stress, and EphB2 downregulation in the mPFC increased the vulnerability to stress.
We here identify that EphB2 receptor tyrosine kinase (show ERBB3 Proteins), which is specifically expressed in glutamatergic neurons, is required for the innate fear responses in the neonatal brain.
Here, we identified the interaction sites of the EphB2 FN domain with ADDLs for the first time to develop a small (10 aa) peptide (Pep63) capable of blocking the EphB2-ADDL (show ADD3 Proteins) interaction.
EphB4 (show EPHB4 Proteins) plays an irreplaceable role in bone regeneration in an inflammatory microenvironment, whereas the functional loss of ephrinB2 (show EFNB2 Proteins) can be effectively compensated, most possibly by other ephrins with similar chemical structures
Authors suggest that aging is accompanied by the upregulation of miR-204 in the hippocampus, which downregulates EphB2 and results in reduced surface and total NR1 expression.
Findings suggest that a combination of forward and reverse EphB1 (show EPHB1 Proteins)/2 receptor-mediated signaling contribute to posterior branch of the anterior commissure and corpus callosum axon guidance
Results demonstrate that EphB2 reverse signaling plays a unique and requisite role in inhibiting the development of opiate-dependent tolerance in vivo
During re-epithelialization ephrin-B1 (show EFNB1 Proteins) and its receptor EphB2 are both upregulated in vivo, just for the duration of repair.
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.
ephrin receptor EphB2
, EPH receptor B2
, ephrin type-B receptor 2-like
, EPH-like kinase 5
, developmentally-regulated Eph-related tyrosine kinase
, elk-related tyrosine kinase
, eph tyrosine kinase 3
, ephrin type-B receptor 2
, protein-tyrosine kinase HEK5
, renal carcinoma antigen NY-REN-47
, tyrosine-protein kinase TYRO5
, tyrosine-protein kinase receptor EPH-3
, neural kinase
, nuk receptor tyrosine kinase
, tyrosine-protein kinase receptor SEK-3
, embryo kinase 5 protein CEK5