EPH Receptor B2 Protein (EPHB2) (AA 19-543) (His tag)

Catalog No. ABIN7274560

Product Details

Target: EPH Receptor B2 (EPHB2)

Protein Type: Recombinant

Protein Characteristics: AA 19-543

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This EPH Receptor B2 protein is labelled with His tag.

Purpose: Mouse EPHB2 Protein

Sequence: Val19-Leu543

Characteristics: Recombinant Mouse EPHB2 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Val19-Leu543.

Purity: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: EPH Receptor B2 (EPHB2)

Alternative Name: EPHB2 (EPHB2 Products)

Synonyms: CAPB Protein, DRT Protein, EK5 Protein, EPHT3 Protein, ERK Protein, Hek5 Protein, PCBC Protein, Tyro5 Protein, ERK2 Protein, ERT1 Protein, MAPK2 Protein, P42MAPK Protein, PRKM1 Protein, PRKM2 Protein, p38 Protein, p40 Protein, p41 Protein, p41mapk Protein, RGD1564232 Protein, Cek5 Protein, Drt Protein, ETECK Protein, Erk Protein, Nuk Protein, Prkm5 Protein, Qek5 Protein, Sek3 Protein, cek5 Protein, ephb2 Protein, xEphB2 Protein, si:ch73-160e9.1 Protein, tpx2 Protein, wu:fb09e10 Protein, wu:fc64a03 Protein, wu:fi18g12 Protein, zgc:112296 Protein, EPH receptor B2 Protein, mitogen-activated protein kinase 1 Protein, Eph receptor B2 Protein, EPH receptor B2 L homeolog Protein, eph receptor B2a Protein, eph receptor B2b Protein, EPHB2 Protein, MAPK1 Protein, Ephb2 Protein, ephb2.L Protein, ephb2a Protein, ephb2b Protein

Background: EphB2, a receptor tyrosine kinase for ephrin ligands, is overexpressed in various cancers and plays an important role in tumor progression. EPHB2 promotes endothelial-mesenchymal transition (EMT) and elicits associated pathologic characteristics of glioblastoma multiforme (GBM) such as invasion and migration. EPHB2 is epigenetically overexpressed in hypoxia, a condition highly prevalent in malignancy. Furthermore, HIF-2α is required for EPHB2 stabilization by hypoxia.

Molecular Weight: 59.3 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.

Pathways: RTK Signaling, Regulation of long-term Neuronal Synaptic Plasticity, S100 Proteins