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anti-Mouse (Murine) ERBB4 Antibodies:
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Human Polyclonal ERBB4 Primary Antibody for IF, IHC (p) - ABIN389572
Prickett, Agrawal, Wei, Yates, Lin, Wunderlich, Cronin, Cruz, Rosenberg, Samuels: Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4. in Nature genetics 2009
Show all 2 Pubmed References
Human Monoclonal ERBB4 Primary Antibody for FACS - ABIN4897003
Richards, Zweidler-McKay, Van Roy, Speleman, Trevino, Zage, Hughes: Signaling of ERBB receptor tyrosine kinases promotes neuroblastoma growth in vitro and in vivo. in Cancer 2010
Show all 2 Pubmed References
Human Polyclonal ERBB4 Primary Antibody for FACS, IF (p) - ABIN737436
Zhao: Expression and Localization of Neuregulin-1 (Nrg1) and ErbB2/ErbB4 Receptors in Main Endocrine Organs of the Rhesus Monkey. in International journal of endocrinology and metabolism 2013
Human Polyclonal ERBB4 Primary Antibody for IHC (p) - ABIN2473486
Jones: Physiologic emboli changes observed during total hip replacement arthroplasty. A clinical prospective study. in Clinical orthopaedics and related research 1976
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Human Polyclonal ERBB4 Primary Antibody for IHC (p), WB - ABIN391950
Cheng, Tikhomirov, Zhou, Carpenter: Ectodomain cleavage of ErbB-4: characterization of the cleavage site and m80 fragment. in The Journal of biological chemistry 2003
Show all 4 Pubmed References
Human Monoclonal ERBB4 Primary Antibody for FACS - ABIN4897002
Mirkina, Hadzijusufovic, Krepler, Mikula, Mechtcheriakova, Strommer, Stella, Jensen-Jarolim, Höller, Wacheck, Pehamberger, Valent: Phenotyping of human melanoma cells reveals a unique composition of receptor targets and a subpopulation co-expressing ErbB4, EPO-R and NGF-R. in PLoS ONE 2014
Human Monoclonal ERBB4 Primary Antibody for CyTOF, FACS - ABIN4899977
Khelwatty, Essapen, Seddon, Modjtahedi: Growth response of human colorectal tumour cell lines to treatment with afatinib (BIBW2992), an irreversible erbB family blocker, and its association with expression of HER family members. in International journal of oncology 2011
Human Polyclonal ERBB4 Primary Antibody for CyTOF, FACS - ABIN4899978
Kastin, Akerstrom, Pan: Neuregulin-1-beta1 enters brain and spinal cord by receptor-mediated transport. in Journal of neurochemistry 2004
Human Polyclonal ERBB4 Primary Antibody for ICC, IF - ABIN443062
Hsu, Yang, Lin, Tseng, Lin: The significance of Her2 on androgen receptor protein stability in the transition of androgen requirement in prostate cancer cells. in American journal of physiology. Endocrinology and metabolism 2011
Human Monoclonal ERBB4 Primary Antibody for FACS, ICC - ABIN267015
Kawata, Morikawa, Shiosaka, Tamura: Ablation of neuropsin-neuregulin 1 signaling imbalances ErbB4 inhibitory networks and disrupts hippocampal gamma oscillation. in Translational psychiatry 2017
Our findings suggest that ErbB4 splicing may regulate the pruning of excitatory synapses on parvalbumin (show PVALB Antibodies) interneurons in the prefrontal cortex during adolescence.
the NRG-ErbB4 signaling pathway can potentially influence many functional systems throughout the brain of primates, and suggest that major sites of action are areas of the "corticolimbic" network
Widespread expression of ErbB4 receptor mRNAs was found throughout the telencephalon of juvenile and adult monkeys with in situ hybridization, with higher levels in grey matter compared to white matter.
ErbB (show EGFR Antibodies) signaling control both convergent extension and head mesoderm migration during gastrulation.
Result suggest the potential for a paracrine signalling network whereby basal cells secrete neuregulin 1 (Nrg1 (show NRG1 Antibodies)), which acts on luminal cells via Erbb3 (show ERBB3 Antibodies) and Erbb4 receptors.
Data suggest no direct involvement of a classical Nrg-ErbB4 pathway in attention and inhibitory control in mice, while it confirms the involvement of this pathway in other domains relevant to schizophrenia.
Erbb4-IR is a Smad3 (show SMAD3 Antibodies)-dependent lncRNA that promotes renal fibrosis in type 2 diabetic nephropathy by suppressing miR (show MLXIP Antibodies)-29b.
Deleting ErbB4 in parvalbumin-expressing neurons (PV neurons) significantly attenuated oligomeric Abeta-induced suppression of long term potentiation (LTP). Furthermore, specific ablation of ErbB4 in PV neurons via Cre/loxP system greatly improved spatial memory and synaptic plasticity in the hippocampus of human APP-J20 mice.
Study found that the ErbB4 signaling pathway in the prelimbic cortex was necessary to modulate fear expression.
Receptor protein-tyrosine kinase (show FLT4 Antibodies) ErbB-4 (ERBB4) is expressed in the basal layer of human epidermis and cultured keratinocytes as well as in murine epidermis.
The manipulation of NRG1 (show NRG1 Antibodies)/ErbB4 signaling in the present study revealed that NRG1 (show NRG1 Antibodies)/ErbB4 activity in the hippocampus is critical for learning and memory.
This study demonstrated that deletion of the endothelial ErbB4 receptor is associated with reduced glucose transport ability and is a key element involved in energy metabolism for brain function.
we show that the antifibrotic effect of neuregulin-1 (show NRG1 Antibodies) is at least partially mediated through anti-inflammatory activity, linked to receptor tyrosine-protein kinase erbB-4 activation in macrophages
These results suggest that the neuropsin (show KLK8 Antibodies)-NRG1 (show NRG1 Antibodies) signaling system has a role in pathological processes underlying temporal lobe epilepsy by regulating the activity of parvalbumin (show PVALB Antibodies)-expressing interneurons, and that neuropsin (show KLK8 Antibodies) regulates E/I balance and gamma oscillations through NRG1 (show NRG1 Antibodies)-ErbB4 signaling toward parvalbumin (show PVALB Antibodies)-expressing interneurons.
Results found that ERBB4 was highly expressed in gastric cancer cell (GC) lines and tumors and closely related to the poor prognosis of GC patients. Other data indicated that ERBB4 promoted cell proliferation via PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) signaling pathway.
Study found that the protein levels of NRG1 (show NRG1 Antibodies) and ErbB4 were significantly increased in the temporal cortex of patients with symptomatic epilepsy. Also, NRG1 (show NRG1 Antibodies)-ErbB4 signaling suppresses GluN2B (show GRIN2B Antibodies) phosphorylation by Src (show SRC Antibodies) inhibition. GluN2B (show GRIN2B Antibodies) is closely related to synaptic activity and its regulation by the NRG1 (show NRG1 Antibodies)-ErbB4-Src (show SRC Antibodies) signaling axis highlights the importance of NRG1 (show NRG1 Antibodies)-ErbB4 signaling in symptomatic epilepsy pathology.
Results demonstrate that 4-PBA promotes gastric cancer cells migration through upregulation of HER3 (show ERBB3 Antibodies)/HER4 subsequent to increased levels of acetyl-histone and activation of ERK (show EPHB2 Antibodies) signaling.
present study shows that HER4 and/or NDRG1 might play a critical role for the cell survival and chemo-resistance of Osteosarcoma (OS), and could be used as potential therapeutic targets in OS.
This study support the involvement of Neuregulin signaling pathway in smoking behavior but not in alcohol use and abuse, and disclose functional potential for 56 of the 66 associated single-nucleotide polymorphism and underlining the involvement of ERBB4 in SI, ND and NW.
These finding suggests that miR (show MLXIP Antibodies)-302b inhibits key transcription factors and cytokines by targeting ERBB4, IRF2 (show IRF2 Antibodies) and CXCR4 (show CXCR4 Antibodies), implicating its role in the inhibition of CRI in EC.
we have exploited the hidden information inside ErbB4 kinase receptor both at sequence and structural level. PSI-BLAST algorithm is used to search similar sequences against ErbB4 kinase sequence. Top 15 sequences with high identity were selected for finding conserved and variable regions among sequences using multiple sequence alignment
our study demonstrated and highlighted the strong prognostic value of HER4 in breast cancer carcinoma. The detection of the strong association of cytoplasmic HER4 with RFS might serve as an effective tool for investigating the multifunctionality of HER4 in predicting prognosis and its possible contribution to providing optimal treatment to patients with cancer.
In silico analysis suggested that rs1972820 located in the 3'UTR (show UTS2R Antibodies) of ERBB4 gene affects the binding affinity of miR (show MLXIP Antibodies)-3144-3p a potential oncomiRNA. Statistical analysis showed a significant association between SNP rs1972820 G allele and reduced breast cancer risk, odds ratio = 0.443 (95% CI: 0.196-0.998).
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described\; however, not all variants have been fully characterized.
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
, receptor tyrosine-protein kinase erbB-4
, v-erb-a erythroblastic leukemia viral oncogene homolog 4
, receptor tyrosine-protein kinase erbB-4-like
, receptor tyrosine kinase ErbB4
, receptor tyrosine-protein kinase ErbB-4
, ovarian receptor tyrosine kinase erbB4 precusor
, receptor tyrosine kinase
, avian erythroblastosis oncogene B 4
, proto-oncogene-like protein c-ErbB-4
, avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4
, tyrosine kinase-type cell surface receptor HER4