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anti-Human HGF Antibodies:
anti-Mouse (Murine) HGF Antibodies:
anti-Rat (Rattus) HGF Antibodies:
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Mouse (Murine) Polyclonal HGF Primary Antibody for WB - ABIN3042443
Zhang, Wang, Ma, Liu, Zhang, Zhu: Effect of herba centellae on the expression of HGF and MCP-1. in Experimental and therapeutic medicine 2013
Show all 7 Pubmed References
Human Polyclonal HGF Primary Antibody for ICC, IHC (fro) - ABIN4886615
Wen, Zhou, Zhou, Zhou, Luo, Ma: Change in hepatocyte growth factor concentration promote mesenchymal stem cell-mediated osteogenic regeneration. in Journal of cellular and molecular medicine 2012
Show all 7 Pubmed References
Human Polyclonal HGF Primary Antibody for IF (p), IHC (p) - ABIN736551
Yu, He, Jiang, He, Fan, Wang, Geng, Dong: Expression and tissue distribution of hepatocyte growth factor (HGF) and its receptor (c-Met) in alpacas (Vicugna pacos) skins associated with white and brown coat colors. in Acta histochemica 2015
Show all 5 Pubmed References
Cow (Bovine) Polyclonal HGF Primary Antibody for IHC, WB - ABIN2781816
Kitajima, Ide, Ohtsuka, Miyazaki: Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer. in Cancer science 2008
Show all 6 Pubmed References
Human Polyclonal HGF Primary Antibody for IHC (f), ICC - ABIN966282
Gohda, Tsubouchi, Nakayama, Hirono, Sakiyama, Takahashi, Miyazaki, Hashimoto, Daikuhara: Purification and partial characterization of hepatocyte growth factor from plasma of a patient with fulminant hepatic failure. in The Journal of clinical investigation 1988
Show all 3 Pubmed References
Human Polyclonal HGF Primary Antibody for FACS, IHC (p) - ABIN388462
Ryugo, Sawa, Ono, Fukushima, Aleshin, Mizuno, Nakamura, Matsuda: Myocardial protective effect of human recombinant hepatocyte growth factor for prolonged heart graft preservation in rats. in Transplantation 2004
Show all 7 Pubmed References
Human Polyclonal HGF Primary Antibody for PLA, WB - ABIN516424
Ogunwobi, Liu: Hepatocyte growth factor upregulation promotes carcinogenesis and epithelial-mesenchymal transition in hepatocellular carcinoma via Akt and COX-2 pathways. in Clinical & experimental metastasis 2011
Human Monoclonal HGF Primary Antibody for IHC (p), IHC - ABIN438999
Puzio-Kuter, Laddha, Castillo-Martin, Sun, Cordon-Cardo, Chan, Levine: Involvement of tumor suppressors PTEN and p53 in the formation of multiple subtypes of liposarcoma. in Cell death and differentiation 2015
Human Polyclonal HGF Primary Antibody for ELISA, WB - ABIN561254
Bouazza, Kratassiouk, Gjata, Perie, Lacau St Guily, Butler-Browne, Svinartchouk: Analysis of growth factor expression in affected and unaffected muscles of oculo-pharyngeal muscular dystrophy (OPMD) patients: a pilot study. in Neuromuscular disorders : NMD 2009
Human Monoclonal HGF Primary Antibody for ELISA, IHC - ABIN251141
Lin, Teo, Lam, Jeyaseelan, Wang: MicroRNA-10b pleiotropically regulates invasion, angiogenicity and apoptosis of tumor cells resembling mesenchymal subtype of glioblastoma multiforme. in Cell death & disease 2012
Met has a role in promoting formation of double minute chromosomes induced by Sei-1 (show SERTAD1 Antibodies) in NIH-3T3 murine fibroblasts
Genetic activation of the antioxidant transcription factor Nrf2 improves liver damage and repair in hepatocyte-specific c-met-deficient mice mainly through restoring a balance in the cellular redox homeostasis.
MET promoted the development of squamous tumors by stimulating the synthesis and release of ligands that activate the epidermal growth factor receptor (EGFR (show EGFR Antibodies)).
through the activation of EGFR, MET activation parallels a RAS pathway to contribute to human and mouse cutaneous cancers.
Results show that c-MET expression is significantly low in pancreatic neuroendocrine tumors (PNETs) and is under the regulation of Meg3-mediated transcriptional and epigenetic mechanisms which contributes to the pathogenesis of PNETs.
Findings indicate a role for the hepatocyte growth factor receptor HGFR/c-MET pathway in neutrophil recruitment and function and suggest that c-MET inhibitor co-treatment may improve responses to cancer immunotherapy in settings beyond c-MET-dependent tumors.
Results demonstrate a new mechanism for the modulation of synapse formation, whereby MET activation induces an alignment of presynaptic and postsynaptic elements that are necessary for assembly and formation of functional synapses by subsets of neocortical neurons that express MET/beta-catenin (show CTNNB1 Antibodies) complex.
MET signaling regulates intestinal homeostasis and regeneration, as well as adenoma formation. These activities of MET are promoted by the stem cell CD44 (show CD44 Antibodies) isoform CD44v4-10.
a c-Met/ETS-1 (show ETS1 Antibodies)/matrix metalloproteinase-14 (MMP-14 (show MMP14 Antibodies)) axis that controls VE-cadherin (show CDH5 Antibodies) degradation, endothelial mesenchymal transition, and vascular abnormality.
Our results show that BMF (show BMF Antibodies)-derived IL-6/HGF and cancer cell-derived TGF-b1 mediate the interactions between bone marrow-derived myofibroblasts and gastric cancer cells, which regulate cancer stemness and promote tumorigenesis.
In conclusion, these findings indicate that CMs (show Cd2ap Antibodies) derived from primary culture of NPC (show NPC1 Antibodies) fractions of BA liver contain a large amount of active HGF, which may activate hepatic stem/progenitor cells and promote the appearance of hepatocyte-like cells or their clusters through HGF/c-Met signaling.
Oxidative stress contributes to HGF-dependent pro-senescence activity of ovarian cancer cells.
These results hold promise that dual targeting of HGF and MET by combining extracellular ligand inhibitors with intracellular MET TKIs could be an effective intervention strategy for cancer patients who have acquired resistance that is dependent on total MET protein.
cabozantinib suppressed MMP1 (show MMP1 Antibodies) expression by blocking HGF-MET signaling and that HGF-MET-MMP1 (show MMP1 Antibodies) signaling is involved in the invasiveness and proliferation of BCa (show BLNK Antibodies) cells. These results suggest that cabozantinib might prove useful for future treatment of muscle-invasive BCa (show BLNK Antibodies).
The results suggested that HGF may inhibit TEMT (show INMT Antibodies) by inhibiting AngII through the JAK2 (show JAK2 Antibodies)/STAT3 (show STAT3 Antibodies) signaling pathway in HK2 (show HK2 Antibodies) cells and HGF may prevent apoptosis induced by AngII. The present study provides a basis for understanding the mechanisms involved in the inhibition of TEMT (show INMT Antibodies) by HGF, which requires further investigation
The identification of novel small-molecule inhibitors of microtubule polymerization highlights the role of the microtubule cytoskeleton in HGF-induced epithelial scattering.
miRNA-200a expression was inverse correlation with HGF expression in stromal fibroblasts. High miRNA-200a and low HGF expression in stromal fibroblasts may predict a good prognosis in patients with non-small cell lung cancer.
Activation of proHGF by St14 (show ST14 Antibodies) induces mouse embryonic stem cell differentiation.
Study shows that Met and HGF have a multi-factorial relationship to the biology and outcome of breast cancer, influenced by gene copy number and protein expression, activation status, stromal environment, and cellular localisation.
These results reveal the effect of HGF on the distinct pathways of eosinophil secretory functions and also provide novel insights into the role of HGF in the pathogenesis of allergic inflammation.
acute pulmonary embolism associated with an enhanced HGF expression in the lungs, the right ventricle, and the liver
SNPs within bovine HGF gene were significantly associated with growth traits. This will provide a background for application of bovine HGF gene in the selection program in Chinese cattle.
Treatment of the bovine satellite cells (BSC (show SLC12A2 Antibodies)) with ephrin-A5 (show EFNA5 Antibodies) causes a reduction in velocity with a concomitant increase in directed migration. Treatment of BSC (show SLC12A2 Antibodies) with hepatocyte growth factor had no immediate effect on cell motility or migration.
HGF transiently increases gene transcription of angiotensin-converting enzyme (show ACE Antibodies)
Combined administration of mesenchymal stem cells overexpressing IGF-1 (show IGF1 Antibodies) and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model.
In an animal model of acute myocardial infarction relevant to human disease, intracoronary administration of IGF-1 (show IGF1 Antibodies)/hepatocyte growth factor (HGF) is a practical and effective strategy to reduce pathological cardiac remodeling.
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.
fibroblast-derived tumor cytotoxic factor
, hepatocyte growth factor
, lung fibroblast-derived mitogen
, scatter factor
, hepapoietin A
, HGF alpha-chain
, hepatocyte growth factor /scatter factor