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Mouse (Murine) Polyclonal HGF Primary Antibody for WB - ABIN3042443
Zhang, Wang, Ma, Liu, Zhang, Zhu: Effect of herba centellae on the expression of HGF and MCP-1. in Experimental and therapeutic medicine 2013
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Human Polyclonal HGF Primary Antibody for ICC, IHC (fro) - ABIN4886615
Wen, Zhou, Zhou, Zhou, Luo, Ma: Change in hepatocyte growth factor concentration promote mesenchymal stem cell-mediated osteogenic regeneration. in Journal of cellular and molecular medicine 2012
Show all 7 Pubmed References
Cow (Bovine) Polyclonal HGF Primary Antibody for IHC, WB - ABIN2781816
Kitajima, Ide, Ohtsuka, Miyazaki: Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer. in Cancer science 2008
Show all 6 Pubmed References
Human Polyclonal HGF Primary Antibody for IF (p), IHC (p) - ABIN736551
Yu, He, Jiang, He, Fan, Wang, Geng, Dong: Expression and tissue distribution of hepatocyte growth factor (HGF) and its receptor (c-Met) in alpacas (Vicugna pacos) skins associated with white and brown coat colors. in Acta histochemica 2015
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Human Polyclonal HGF Primary Antibody for IHC (f), ICC - ABIN966282
Gohda, Tsubouchi, Nakayama, Hirono, Sakiyama, Takahashi, Miyazaki, Hashimoto, Daikuhara: Purification and partial characterization of hepatocyte growth factor from plasma of a patient with fulminant hepatic failure. in The Journal of clinical investigation 1988
Show all 3 Pubmed References
Human Polyclonal HGF Primary Antibody for FACS, IHC (p) - ABIN388462
Ryugo, Sawa, Ono, Fukushima, Aleshin, Mizuno, Nakamura, Matsuda: Myocardial protective effect of human recombinant hepatocyte growth factor for prolonged heart graft preservation in rats. in Transplantation 2004
Show all 7 Pubmed References
Human Polyclonal HGF Primary Antibody for PLA, WB - ABIN516424
Ogunwobi, Liu: Hepatocyte growth factor upregulation promotes carcinogenesis and epithelial-mesenchymal transition in hepatocellular carcinoma via Akt and COX-2 pathways. in Clinical & experimental metastasis 2011
Human Polyclonal HGF Primary Antibody for ELISA, WB - ABIN561254
Bouazza, Kratassiouk, Gjata, Perie, Lacau St Guily, Butler-Browne, Svinartchouk: Analysis of growth factor expression in affected and unaffected muscles of oculo-pharyngeal muscular dystrophy (OPMD) patients: a pilot study. in Neuromuscular disorders : NMD 2009
Human Monoclonal HGF Primary Antibody for ELISA, IHC - ABIN251141
Lin, Teo, Lam, Jeyaseelan, Wang: MicroRNA-10b pleiotropically regulates invasion, angiogenicity and apoptosis of tumor cells resembling mesenchymal subtype of glioblastoma multiforme. in Cell death & disease 2012
Human Monoclonal HGF Primary Antibody for IHC (p), IHC - ABIN438999
Puzio-Kuter, Laddha, Castillo-Martin, Sun, Cordon-Cardo, Chan, Levine: Involvement of tumor suppressors PTEN and p53 in the formation of multiple subtypes of liposarcoma. in Cell death and differentiation 2015
Hepatocyte growth factor as cardiovascular hormone: role of HGF in the pathogenesis of cardiovascular disease. Review.
this study shows that decidual NK cells facilitate the interaction between trophoblastic and endothelial cells via VEGF-C (show VEGFC Antibodies) and HGF
We identify HGF, acting through the c-Met receptor, as the key polarity-inducing morphogen (show SHH Antibodies), which acts to activate b1-integrin-dependent adhesion. HGF and ECM (show MMRN1 Antibodies)-derived integrin signals co-operate via a c-Src (show SRC Antibodies)-dependent inhibition of the RhoA (show RHOA Antibodies)-ROCK1 (show ROCK1 Antibodies) signalling pathway via p190A (show GRLF1 Antibodies) RhoGAP (show ARHGAP1 Antibodies).
High glucose activated Met receptor in HK2 (show HK2 Antibodies) cells independently of HGF, via induction of integrin a5b1 and downstream signaling. This mode of Met activation was associated with tubular cell damage and apoptosis and it may represent a novel pathogenic mechanism and a treatment target in diabetic nephropathy.
results show that HGF was involved in regulating Chk1 (show CHEK1 Antibodies) phosphorylation, and further demonstrate that AKT (show AKT1 Antibodies) activity was responsible for this HGF-induced Chk1 (show CHEK1 Antibodies) phosphorylation.
Lymph node metastasis is strongly associated with expression status of HGF and CD133 at the deep invasive front, suggesting the usefulness of these proteins as independent predictive markers of lymph node metastasis in early gastric cancer.
EGF (show EGF Antibodies)-mediated lysosome trafficking, protease secretion, and invasion is regulated by the activity of p38 mitogen activated protein kinase (show MAPK14 Antibodies) (MAPK (show MAPK1 Antibodies)) and sodium hydrogen exchangers (NHEs). Interestingly, EGF (show EGF Antibodies) stimulates anterograde lysosome trafficking through a different mechanism than previously reported for HGF, suggesting that there are redundant signaling pathways that control lysosome positioning
HGF/c-MET pathway mediates VEGFR (show KDR Antibodies) inhibitor resistance and vascular remodeling in NSCLC.
We also propose that full-length HGF and HGF-NK1 convey desirable wound healing properties, whilst fibroblasts preferentially expressing more HGF-NK2 readily undergo TGF-beta (show TGFB1 Antibodies)-driven differentiation into myofibroblasts.
In conclusion, these findings indicate that CMs (show Cd2ap Antibodies) derived from primary culture of NPC (show NPC1 Antibodies) fractions of BA liver contain a large amount of active HGF, which may activate hepatic stem/progenitor cells and promote the appearance of hepatocyte-like cells or their clusters through HGF/c-Met signaling.
Mesenchymal stem cells microvesicles stabilization of endothelial barrier function is partly mediated by hepatocyte growth factor.
HGF supports hindlimb motor neurons through c-Met; CNTF (show CNTF Antibodies) supports subsets of axial motor neurons through CNTFRalpha (show CNTFR Antibodies); and Artemin (show ARTN Antibodies) acts as the first survival factor for parasympathetic preganglionic motor neurons through GFRalpha3 (show GFRA3 Antibodies)/Syndecan-3 (show SDC3 Antibodies) activation.
Study used biochemical and morphological analyses to demonstrate that two discrete intracellular signaling pathways underlie distinct HGF-induced biological outcomes in developing neocortical neurons. Further, it identified a key developmental epoch, corresponding to the period of dendritic outgrowth and synaptogenesis, during which HGF stimulation elicits maximal activation of MET in the neocortex.
Our results show that BMF (show BMF Antibodies)-derived IL-6/HGF and cancer cell-derived TGF-b1 mediate the interactions between bone marrow-derived myofibroblasts and gastric cancer cells, which regulate cancer stemness and promote tumorigenesis.
this study demonstrates an important role for HGF in the protective effects mediated by mesenchymal stromal cells in vivo in the bleomycin model of idiopathic pulmonary fibrosis
HGF displays an antioxidant response by inducing the glutathione-related protection system.
this study revealed that HB-EGF (show HBEGF Antibodies) as well as HGF inhibited BDL-induced cholestatic liver injury by predominantly exerting acute cytoprotective and chronic antifibrotic effects, respectively.
The results suggest that PGRN (show GRN Antibodies) may affect the differentiation of retinal precursor cells to photoreceptor cells through the HGF receptor signaling pathway.
Exposure of macrophages to cyclooxygenase (COX-2 (show COX2 Antibodies)) inhibitors RhoA (show RHOA Antibodies) and LA-4 cells to antagonists of prostaglandin E2 (PGE2) receptor , PGD2 (show PTGDS Antibodies) receptors or the hepatocyte growth factor (HGF) receptor c-Met (PHA (show LBR Antibodies)-665752), reversed EMT (show ITK Antibodies) inhibition by the conditioned medium
Notch (show NOTCH1 Antibodies) signaling plays an important role in regulation of interactions between TGF-beta (show TGFB1 Antibodies) and HGF signaling pathways in proximal tubule epithelial cells
SNPs within bovine HGF gene were significantly associated with growth traits. This will provide a background for application of bovine HGF gene in the selection program in Chinese cattle.
Treatment of the bovine satellite cells (BSC (show SLC12A2 Antibodies)) with ephrin-A5 (show EFNA5 Antibodies) causes a reduction in velocity with a concomitant increase in directed migration. Treatment of BSC (show SLC12A2 Antibodies) with hepatocyte growth factor had no immediate effect on cell motility or migration.
HGF transiently increases gene transcription of angiotensin-converting enzyme (show ACE Antibodies)
acute pulmonary embolism associated with an enhanced HGF expression in the lungs, the right ventricle, and the liver
Combined administration of mesenchymal stem cells overexpressing IGF-1 (show IGF1 Antibodies) and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model.
In an animal model of acute myocardial infarction relevant to human disease, intracoronary administration of IGF-1 (show IGF1 Antibodies)/hepatocyte growth factor (HGF) is a practical and effective strategy to reduce pathological cardiac remodeling.
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.
fibroblast-derived tumor cytotoxic factor
, hepatocyte growth factor
, lung fibroblast-derived mitogen
, scatter factor
, hepapoietin A
, HGF alpha-chain
, hepatocyte growth factor /scatter factor