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anti-Human PDGFA Antibodies:
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Human Polyclonal PDGFA Primary Antibody for IF (p), IHC (p) - ABIN726155
Lee, Zheng, Kang, Kim, Oh, Cho: Therapeutic efficacy of autologous platelet-rich plasma and polydeoxyribonucleotide on female pattern hair loss. in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2015
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Human Monoclonal PDGFA Primary Antibody for ELISA - ABIN2476089
Gaillard, Haguenauer, Gignoux, Barbier, Romanet: [Bilateral cancer of the ethmoid bone of occupational origin]. in JFORL. Journal français d'oto-rhino-laryngologie; audiophonologie et chirurgie maxillo-faciale 1976
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Human Polyclonal PDGFA Primary Antibody for Func, IHC (p) - ABIN2476090
Rorsman, Bywater, Knott, Scott, Betsholtz: Structural characterization of the human platelet-derived growth factor A-chain cDNA and gene: alternative exon usage predicts two different precursor proteins. in Molecular and cellular biology 1988
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Human Polyclonal PDGFA Primary Antibody for Func, IHC (p) - ABIN2476092
Rao, Igarashi, Chiu, Robbins, Aaronson: Structure and sequence of the human c-sis/platelet-derived growth factor 2 (SIS/PDGF2) transcriptional unit. in Proceedings of the National Academy of Sciences of the United States of America 1986
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Hypomethylation at a CpG site in PDGFA (encoding platelet-derived growth factor alpha) and PDGFA overexpression are both associated with increased T2 diabetes risk, hyperinsulinemia, increased insulin (show INS Antibodies) resistance, and increased steatohepatitis risk.
PDGFA was down-regulated in the malignant Middle Cerebral Artery Infarction.
this study uncovers a novel mechanism of the Nrf2 (show GABPA Antibodies)/PDGFA regulatory loop that is crucial for AKT (show AKT1 Antibodies)-dependent hepatocellular carcinoma progression
Tumor cell induced mesenchymal stromal cell chemotaxis appears to be mediated through paracrine secretion of PDGF-AA.
PDGFAA in tumor drainage and HER2 (show ERBB2 Antibodies) in peripheral vein blood may have roles in synchronous liver metastasis of colorectal cancer
Insulin (show INS Antibodies) treatment caused sustained Akt (show AKT1 Antibodies) activity, whereas EGF (show EGF Antibodies) or PDGF-AA promoted transient signaling; PDGF-BB produced sustained responses at higher concentrations.Transient responses to EGF (show EGF Antibodies) were caused by negative feedback at the receptor level, as a second treatment yielded minimal responses, whereas parallel exposure to IGF-I (show IGF1 Antibodies) caused full Akt (show AKT1 Antibodies) activation
these findings suggest that IGFBP-3 (show IGFBP3 Antibodies) suppresses transcription of EGR1 (show EGR1 Antibodies) and its target genes bFGF (show FGF2 Antibodies) and PDGF through inhibiting IGF-1 (show IGF1 Antibodies)-dependent ERK (show EPHB2 Antibodies) and AKT (show AKT1 Antibodies) activation.
Based on a luciferase reporter assay, plateletderived growth factorA (PDGFA) was identified as a direct target gene of miR375. Additionally, overexpression of PDGFA significantly reversed the effect of miR375 on cell migration and invasion in oral squamous cell carcinoma cell.
The highest PDGF AA levels were found in mothers of fetuses with hypoplastic left heart syndrome . These findings may be useful in screening for congenital heart defects (CCHDs) and offer insight into their association with nuchal translucency
Low concentration of PDGF-AB showed synergism with IFN-alpha (show IFNA Antibodies) in IFN-beta (show IFNB1 Antibodies) and -gamma induction.
Zebrafish pdgf-a mRNA was present at high levels in fertilized eggs as well as in all embryonic cells up to the end of gastrulation
PDGF-A signaling is involved in myofibroblast proliferation and migration.
These studies uncover PI3K/AKT2 (show AKT2 Antibodies) as a direct PDGFA target that is activated in adipocyte stem cells.
stronger fibrotic effect generated by Platelet-derived growth factor alpha overexpression was mediated by Platelet-derived growth factor receptor (show PDGFRB Antibodies) alphalpha in cardiac interstitial mesenchymal cells
PDGF-AA impairs endothelium-dependent vasodilation and PDGF-AA mediates BMP4 (show BMP4 Antibodies)-induced adverse effect on endothelial cell function through SMAD1 (show SMAD1 Antibodies)/5- and SMAD4 (show SMAD4 Antibodies)-dependent mechanisms.
Both cell proliferation and hair inductive activity in murine DPCs are maintained by the synergistic effect of fibroblast growth factor 2 (show FGF2 Antibodies) and platelet-derived growth factor receptor alpha (show PDGFRA Antibodies).
Primary high invasive Glioma initiating cells SU3 contribute to transformation of adjacent normal host glial cells in local tumor microenvironment possibly via PDGF/PDGFR (show PDGFRB Antibodies) signaling activation.
Silencing the Col4-alpha1 gene or disrupting integrin engagement by blocking the antibody reduced the expression of platelet-derived growth factor A (PDGF-A), a potent chemotactic factor for fibroblasts.
Platelet-derived growth factor mediates interleukin-13 (show IL13 Antibodies)-induced collagen I production in mouse airway fibroblasts.
senescent cells have a role in optimal wound healing through secretion of PDGF-AA
leading to a PDGF-responsive SRF-driven transcriptional program in the midface
PDGF-A/PDGFRalpha signalling as a tissue-autonomous regulator of contact inhibition of locomotion by controlling N-cadherin (show CDH2 Antibodies) upregulation during epithelial-to-mesenchymal transition.
When PDGF-A signaling is inhibited, prechordal mesoderm cells fail to orient towards the ectoderm, the endogenous source of PDGF-A, and no longer migrate towards it.
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis\; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene.
, PDGF subunit A
, platelet-derived growth factor A chain
, platelet-derived growth factor alpha chain
, platelet-derived growth factor alpha isoform 2 preproprotein
, platelet-derived growth factor subunit A
, platelet-derived growth factor alpha polypeptide
, Platelet-derived growth factor A chain
, platelet derived growth factor, alpha
, PDGF-A (S1)
, platelet-derived growth factor A chain long form
, platelet-derived growth factor A chain short form type 1
, platelet-derived growth factor A chain short form type 2
, platelet-derived growth factor A-chain
, platelet-derived growth factor A chain, long form
, platelet derived growth factor alpha b
, platelet-derived growth factor alpha polypeptide b