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This review showed that PDGFB was one of the common gene involved included with brain calcification.
Rare Skin Tumor Dermatofibrosarcoma Protuberans (DFSP) is characterized by the translocation of the PDGFB (show PDGFB Antibodies) gene to the collagen 1A1 (show COL1A1 Antibodies) gene.
Transglutaminase type 2 affects cell migration through post-translational modification of PDGF (show PDGFA Antibodies)-BB.
PDGF-B (show PDGFB Antibodies) rs1800818 polymorphism might play a role in mediating the susceptibility to severe fever with thrombocytopenia syndrome in Chinese individuals.
PDAP-1 (show PDAP1 Antibodies) as an effecter of PDGF (show PDGFA Antibodies) signaling in glioma cells
High PDGFB expression is associated with gastric cancer.
We observed that regenerating and necrotic muscle fibers in muscle biopsy samples from Duchenne muscular dystrophy (show DMD Antibodies) patients expressed PDGF (show PDGFA Antibodies)-BB.
Elevated PDGFB (show PDGFB Antibodies) expression was noted in 29% of patients with papillary renal cell carcinoma (show MOK Antibodies).
Insulin (show INS Antibodies) treatment caused sustained Akt (show AKT1 Antibodies) activity, whereas EGF (show EGF Antibodies) or PDGF (show PDGFA Antibodies)-AA promoted transient signaling; PDGF (show PDGFA Antibodies)-BB produced sustained responses at higher concentrations.Transient responses to EGF (show EGF Antibodies) were caused by negative feedback at the receptor level, as a second treatment yielded minimal responses, whereas parallel exposure to IGF-I (show IGF1 Antibodies) caused full Akt (show AKT1 Antibodies) activation
high-throughput affinity plasma proteomic profiling is a valuable research strategy to identify potential candidate biomarkers for thrombosis-related disorders, and our study suggests a novel association of PDGFB plasma levels with venous thromboembolism.
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
PDGF subunit B
, PDGF, B chain
, platelet-derived growth factor 2
, platelet-derived growth factor B chain
, platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
, platelet-derived growth factor subunit B
, platelet-derived growth factor, beta polypeptide (oncogene SIS)
, proto-oncogene c-Sis