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anti-Mouse (Murine) PDGFRA Antibodies:
anti-Rat (Rattus) PDGFRA Antibodies:
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Human Monoclonal PDGFRA Primary Antibody for FACS, IP - ABIN4900645
Velghe, Van Cauwenberghe, Polyansky, Chand, Montano-Almendras, Charni, Hallberg, Essaghir, Demoulin: PDGFRA alterations in cancer: characterization of a gain-of-function V536E transmembrane mutant as well as loss-of-function and passenger mutations. in Oncogene 2014
Show all 6 Pubmed References
Human Monoclonal PDGFRA Primary Antibody for FACS - ABIN4898823
Uosaki, Andersen, Shenje, Fernandez, Christiansen, Kwon: Direct contact with endoderm-like cells efficiently induces cardiac progenitors from mouse and human pluripotent stem cells. in PLoS ONE 2012
Show all 4 Pubmed References
Mouse (Murine) Monoclonal PDGFRA Primary Antibody for FACS - ABIN1176995
Fruttiger, Calver, Krüger, Mudhar, Michalovich, Takakura, Nishikawa, Richardson: PDGF mediates a neuron-astrocyte interaction in the developing retina. in Neuron 1997
Show all 3 Pubmed References
Human Polyclonal PDGFRA Primary Antibody for WB - ABIN271391
Zheng, Ishii, Tokunaga, Hamashima, Shen, Zhao, Ishizawa, Fujimori, Nabeshima, Mori, Kondo, Sasahara: Neuroprotective effects of PDGF against oxidative stress and the signaling pathway involved. in Journal of neuroscience research 2010
Show all 3 Pubmed References
Human Monoclonal PDGFRA Primary Antibody for FACS - ABIN4898820
Craft, Rockel, Nartiss, Kandel, Alman, Keller: Generation of articular chondrocytes from human pluripotent stem cells. in Nature biotechnology 2015
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Human Polyclonal PDGFRA Primary Antibody for PLA, WB - ABIN518742
Moroncini, Grieco, Nacci, Paolini, Tonnini, Pozniak, Cuccioloni, Mozzicafreddo, Svegliati, Angeletti, Kazlauskas, Avvedimento, Funaro, Gabrielli: Epitope Specificity Determines Pathogenicity and Detectability of Anti-Platelet-Derived Growth Factor Receptor α Autoantibodies in Systemic Sclerosis. in Arthritis & rheumatology (Hoboken, N.J.) 2015
Human Monoclonal PDGFRA Primary Antibody for PLA, ELISA - ABIN518743
Dugas, Cuellar, Scholze, Ason, Ibrahim, Emery, Zamanian, Foo, McManus, Barres: Dicer1 and miR-219 Are required for normal oligodendrocyte differentiation and myelination. in Neuron 2010
Human Polyclonal PDGFRA Primary Antibody for IF (p), IHC (p) - ABIN726620
Hu, Zeng, Jiang, Hu, Meng, Zhu, Mao: The expression of marker for endometrial stem cell and fibrosis was increased in intrauterine adhesious. in International journal of clinical and experimental pathology 2015
Human Polyclonal PDGFRA Primary Antibody for IHC (p), WB - ABIN392024
Wilczynski, Chen, Chen, Howell, Shively, Alberts: Expression and mutational analysis of tyrosine kinase receptors c-kit, PDGFRalpha, and PDGFRbeta in ovarian cancers. in Human pathology 2005
Show all 6 Pubmed References
Human Monoclonal PDGFRA Primary Antibody for Func, FACS - ABIN2688972
Bazenet, Kazlauskas: The PDGF receptor alpha subunit activates p21ras and triggers DNA synthesis without interacting with rasGAP. in Oncogene 1994
PDGFRA is not essential for the derivation and maintenance of extraembryonic endoderm stem (XEN) cell lines .
loss of Pdgfra in endothelial-derived (show MED28 Antibodies) mesenchyme in the outflow tract endocardial cushions leads to a secondary defect in neural crest migration during development.
Investigated the developmental process of mesenchymal stem cells (MSCs) in embryos using the gene Pdgfra as a marker. We traced cells expressing Pdgfra and other genes (brachyury (show TBX1 Antibodies), Sox1 (show SOX1 Antibodies) and Pmx1 (show PRRX1 Antibodies)) in various mutant embryos until the adult stage. Embryonic MSCs emerge in waves and almost all adult bone marrow MSCs and white adipose tissue MSCs originate from mesoderm and embryonic Pdgfralpha-positive cells.
PDGFRalpha/PDGFRbeta signaling balance determines progenitor commitment to beige (show LYST Antibodies) (PDGFRalpha) or white (PDGFRbeta) adipogenesis.
Spreading of PDGFR-alpha-deficient lung fibroblasts was insensitive to increased rigidity, and their migration was not reduced by Rac1 (show RAC1 Antibodies)-guanine exchange factor (GEF (show ARHGEF2 Antibodies))-inhibition. PDGFR-alpha-expressing fibroblasts migrated toward stiffer regions within two-dimensional substrates by increasing migrational persistence (durotaxis).
Histone H3.3K27M and Trp53 (show TP53 Antibodies) loss and PDGFRA overexpression accelerates disease onset and increases tumor invasion.
The diabetes-induced increase in PDGFRalpha+ cells may be mediated by FOXO3 up-regulation via the inhibition of the PI3K/Akt signaling pathway in STZ-induced diabetic mice.
Constitutive activation of PDGFRalpha leads to expansion of cartilage underlying the coronal sutures, which contribute to suture closure through endochondral ossification, in a process regulated in part by PI3K/AKT (show AKT1 Antibodies) signaling.
OLIG2 (show OLIG2 Antibodies) modulates growth factor signaling in two distinct populations of glioma stem cells, characterized by expression of either the epidermal growth factor receptor (EGFR (show EGFR Antibodies)) or platelet-derived growth factor receptor alpha.
Conditional knockout of Pdgfra in Pdgfra-expressing tissues in mouse embryos at different embryonic days (E9.5 and E10.5) resulted in multiple developmental anomalies of the frontonasal region, the cranium and the abdominal wall musculature. Furthermore, the day at which the Pdgfra is deleted influences the repertoire of the anomalies of the conditional knockout embryos.
High PDGFR (show PDGFRB Antibodies) expression is associated with retinal neovascularization.
PDGFRA D842V mutant binds imatinib with lower affinity with respect to wild-type structure, showing higher stability during the interaction with other type I TKIs (like crenolanib).
Altered SK3 channel expression observed in PDGFRalpha(+) cells in UPJ obstruction suggests that the impairment of SK3 activity across the UPJ may perturb upper urinary tract peristalsis in this urological condition
None of the 16 analyzable tumors showed mutations in PDGFRA. Thus, PDGFRA mutations probably do not play an important role in the development of sporadic lipomas of the intestines
Whole transcriptome sequencing followed by pathway analysis indicated that STXBP4 (show STXBP4 Antibodies) is involved in functional gene networks that regulate cell growth, proliferation, cell death, and survival in cancer. Platelet-derived growth factor receptor alpha (PDGFRalpha) was a key downstream mediator of STXBP4 (show STXBP4 Antibodies) function. In line with this, shRNA mediated STXBP4 (show STXBP4 Antibodies) and PDGFRA knockdown suppressed tumor growth in soft-agar and xenograft ...
We report a unique case of an SDH (show SARDH Antibodies)-deficient GIST case with an activating PDGFRA mutation. Oncogenic mutations in GIST are generally mutually exclusive; however documented exceptions exist which may have diagnostic and therapeutic implications.
Case Report: concurrent development of myeloproliferative hypereosinophilic syndrome and lymphomatoid papulosis associated with FIP1L1 (show FIP1L1 Antibodies)-PDGFRA gene fusion.
Our results suggest that PDGFRalpha overexpression in HCC (show FAM126A Antibodies) is a prognostic marker independent of adjacent non-tumor site liver fibrosis status.
overview of primary cilia-mediated regulation of receptor tyrosine kinase (show RET Antibodies) (RTK- PDGFRa and PDGFRb (show PDGFRB Antibodies)) and transforming growth factor beta (TGF-beta) signaling [review]
PDGFRA mutation, but not amplification is associated with older age in pediatric high-grade glioma.
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.
platelet-derived growth factor receptor, alpha polypeptide
, alpha-type platelet-derived growth factor receptor-like
, Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha)
, CD140 antigen-like family member A
, PDGF alpha chain
, alpha-type platelet-derived growth factor receptor
, platelet-derived growth factor alpha receptor
, platelet-derived growth factor receptor alpha
, alpha platelet-derived growth factor receptor
, CD140a antigen
, PDGFRA/BCR fusion
, platelet-derived growth factor receptor 2
, rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein
, tyrosine kinase PDGFR