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PDGFRA antibody (AA 1048-1077)

PDGFRA Reactivity: Human, Mouse FACS, IHC, ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3032254
$578.58
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  • Target See all PDGFRA Antibodies
    PDGFRA (Platelet Derived Growth Factor Receptor alpha (PDGFRA))
    Binding Specificity
    • 23
    • 18
    • 17
    • 16
    • 16
    • 15
    • 15
    • 13
    • 12
    • 11
    • 10
    • 10
    • 10
    • 9
    • 9
    • 8
    • 7
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1048-1077
    Reactivity
    • 274
    • 143
    • 86
    • 20
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 255
    • 36
    • 4
    • 1
    Rabbit
    Clonality
    • 249
    • 47
    Polyclonal
    Conjugate
    • 118
    • 22
    • 20
    • 19
    • 15
    • 12
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 5
    • 5
    • 5
    • 5
    • 5
    • 1
    • 1
    This PDGFRA antibody is un-conjugated
    Application
    • 161
    • 123
    • 80
    • 66
    • 54
    • 53
    • 38
    • 25
    • 23
    • 14
    • 7
    • 7
    • 7
    • 5
    • 3
    • 2
    • 1
    Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
    Cross-Reactivity (Details)
    Expected species reactivity: Chicken, Rat
    Purification
    Purified
    Immunogen
    A portion of amino acids 1048-1077 from the human protein was used as the immunogen for this CD140a / PDGFRA antibody.
    Isotype
    Ig Fraction
  • Application Notes
    Titration of the PDGFRA antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100,Flow Cytometry: 1:10-1:50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the PDGFRA antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    PDGFRA (Platelet Derived Growth Factor Receptor alpha (PDGFRA))
    Alternative Name
    PDGFRA (CD140a) (PDGFRA Products)
    Synonyms
    AI115593 antibody, CD140a antibody, Pdgfr-2 antibody, APDGFR antibody, PDGFACE antibody, CD140A antibody, PDGFR-2 antibody, PDGFR2 antibody, RHEPDGFRA antibody, PDGFR antibody, PDGFR-A antibody, platelet derived growth factor receptor alpha antibody, platelet derived growth factor receptor, alpha polypeptide antibody, platelet-derived growth factor receptor, alpha polypeptide L homeolog antibody, platelet-derived growth factor receptor, alpha polypeptide antibody, PDGFRA antibody, Pdgfra antibody, pdgfra.L antibody
    Background
    PDGFRA is a tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades, the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca2+ and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. [UniProt]
    UniProt
    P16234
    Pathways
    RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Platelet-derived growth Factor Receptor Signaling
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