Browse our PPP3R1 Proteins (PPP3R1)

Human Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) interaction partners

1. The CnB 5I/5D variation was found to be significantly associated with CAD. The 5-base pair deletion results in increased serum calcineurin levels.

2. The mRNA expressions of PPP3CB (show PPP3CB Proteins) and MEF2C (show MEF2C Proteins) were significantly up-regulated, and CAMK1 (show CAMK1 Proteins) and PPP3R1 were significantly down-regulated in mitral regurgitation(MR) patients compared to normal subjects. Moreover, MR patients had significantly increased mRNA levels of PPP3CB (show PPP3CB Proteins), MEF2C (show MEF2C Proteins) and PLCE1 (show PLCE1 Proteins) compared to aortic valve disease patients

3. we report that exogenous CnB is taken up by cells in a time- and concentration-dependent manner via clathrin-dependent receptor-mediated internalization. Our findings further confirm that uptake is mediated by the TLR4 (show TLR4 Proteins)/MD2 (show LY96 Proteins) complex together with the co-receptor CD14 (show NDUFA2 Proteins)

4. CnB is a novel host-derived immunostimulatory factor, having a role as an agonist in monocytes, and specificity in TLR4 (show TLR4 Proteins) signaling through TRAF3 (show TRAF3 Proteins) and TRAF6 (show TRAF6 Proteins), in response to various agonists.

5. Data (including data from micro-dissected trophoblasts and trophoblastic BeWo cell line) suggest that microRNA-512-3p participates in placental function by targeting PPP3R1, encoding a regulatory subunit of calcineurin B.

6. Further evidence that specific variations in MAPT (show MAPT Proteins) (rs3785883) and PPP3R1 (rs1868402) are associated with accelerated progression of Alzheimer's disease

7. Expression level of PPP3R1 and GATA4 (show GATA4 Proteins), and NFATC4 (show NFATC4 Proteins) genes for transcription factors did not differ in studied subgroups of patients.

8. Pancreatic beta cells lacking Cnb1 fail to express genes revealed to be direct NFAT (show NFATC1 Proteins) targets required for replication, insulin (show INS Proteins) storage, and secretion.

9. These findings reveal a novel signaling pathway (CnB-CD11b (show ITGAM Proteins)-NF-kappaB (show NFKB1 Proteins)-TRAIL) regulating TRAIL expression and may help to understand the roles of the calcineurin B subunit in the regulation of innate immunity.

10. CnB M118K fails to enhance the activities of NF-AT and p53 induced by CnA in HeLa-s cells.

Mouse (Murine) Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) interaction partners

1. These results suggest that the PDZ domain of PICK1 (show PICK1 Proteins) directly interacts with calcineurin B in osteoclast progenitor cells and promotes osteoclast differentiation through activation of calcineurin-NFAT (show NFATC1 Proteins) signaling.

2. global deficiency of catalytic subunit Ppp3cb (show PPP3CB Proteins), and tissue-specific ablation of regulatory subunit Ppp3r1 from skeletal muscle, but not adipose tissue or liver, led to protection from high-fat-diet-induced obesity

3. data demonstrate that decreasing calcineurin activity in the amygdala increases anxiety-like behaviors and to some extent depression-like behaviors.

4. Macrophage Wnt (show WNT2 Proteins)-Calcineurin-Flt1 (show FLT1 Proteins) signaling regulates mouse wound angiogenesis and repair.

5. Pancreatic beta cells lacking Cnb1 fail to express genes revealed to be direct NFAT (show NFATC1 Proteins) targets required for replication, insulin (show INS Proteins) storage, and secretion.

6. intact calcineurin/NFAT (show NFATC1 Proteins) signalling is critically required for p53 (show TP53 Proteins) and senescence-associated mechanisms that protect against skin squamous cancer development

7. Mechanistically, loss of Heart-specific CnB1 reduced expression of key Ca(2 (show CA2 Proteins)+)-handling genes that likely lead to arrhythmia and reduced contractility

8. Calcineurin B1 is essential for positive selection during thymocyte development.

9. gene expression of peroxisome proliferator-activated receptor gamma (show PPARG Proteins) coactivator 1alpha and peroxisome proliferator-activated receptor alpha (show PPARA Proteins) was reduced in the hearts of mice with cardiac-specific ablation of the Cn regulatory subunit.

10. interconnection exists between Notch 1 (show NOTCH1 Proteins) and Calcineurin-NFAT (show NFATC1 Proteins) pathways in keratinocyte growth/differentiation control