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genetic variants in BICC1 and RASGRF1 are closely associated with high myopia, which appears to be a potential candidate for high myopia in Chinese Han population.
Endoplasmic reticulum stress triggers a localized signaling module on the ER surface involving Nox4-dependent calcium mobilization, which directs local Ras activation through ER-associated, calcium-responsive RasGRF.
Data show that microRNA miR (show MLXIP Proteins)-137 directly recognized the 3'-UTR (3'-untranslated region) of the RASGRF1 (Ras protein-specific guanine nucleotide-releasing factor 1) transcript and regulated RASGRF1 expression.
Impaired RASGRF1/ERK (show EPHB2 Proteins)-mediated GM-CSF (show CSF2 Proteins) response characterizes CARD9 (show CARD9 Proteins) deficiency in French-Canadians.
Carriers of the rs8027411 G allele in the RASGRF1 gene may be at a lower risk of high myopia in Chinese and Japanese populations. (Meta-analysis)
Rasgrf-1 is a novel GEF (show SLC2A4RG Proteins) protein that has a role in BCR (show BCR Proteins) signaling and its overexpression further activates the Ras/Erk/MAPK (show MAPK1 Proteins) pathway in CLL specimens.
In this study, there was no association of the analyzed SNPs located in RASGRF1. GJD2 (show GJD2 Proteins), and ACTC1 (show ACTC1 Proteins) with pathological myopia.
CARD9 (show CARD9 Proteins) regulates H-Ras (show HRAS Proteins) activation by linking Ras-GRF1 to H-Ras (show HRAS Proteins), which mediates Dectin-1 (show CLEC7A Proteins)-induced extracellular signal-regulated protein kinase (show CDK7 Proteins) (ERK (show EPHB2 Proteins)) activation and proinflammatory responses when stimulated by their ligands.
ZIC2 (show ZIC2 Proteins) and RASGRF1 are susceptibility genes, not only for common myopia, but also for high myopia.
Decreased expression of Ras-GRF1 could be involved in the pathogenesis of human temporal lobe epilepsy.
Novel mercaptoacetamide-based class II histone deacetylase (show HDAC1 Proteins) inhibitor HDACIW2 treatment regulated the levels of RasGRF1 and p-ERK (show EPHB2 Proteins), and that W2 requires RasGRF1 and ERK (show EPHB2 Proteins) signaling to alter dendritic spine formation, suggesting that W2 regulates dendritic spine formation via a RasGRF1/ERK (show EPHB2 Proteins)-dependent signaling pathway
Data (including data from studies in knockout mice) suggest mechanisms involving RasGRF1 exist to regulate hypothalamic-pituitary-adrenal axis in early-adolescent females; such mechanisms appear absent in younger/older female or adolescent male mice.
VLDLR (show VLDLR Proteins) requires RasGRF1/CaMKII (show CAMK2G Proteins) to alter dendritic spine formation.
Study suggests a complex role of ERK (show EPHB2 Proteins)-dependent and Ras-GRF1-dependent signaling in corticostriatal plasticity, highlights differences between synaptic mechanisms in naive slices and dopamine-depleted preparations from L-DOPA-treated dyskinetic animals
RasGrf1 is an important upstream component of signal transduction pathways regulating Pttg1 (show PTTG1 Proteins) expression and controlling beta cell development and physiological responses.
GRF1 is expressed in new neurons when GRF1 loss begins to effect neuronal function, promoting late stages of adult neurogenesis. GRF1 is an age-dependent regulator of adult hippocampal neurogenesis and the ability to distinguish closely related contexts.
Data indicate that contextual discrimination involves term potentiation (LTP (show SCP2 Proteins)) promoted by calcium-permeable AMPA (show GRIA3 Proteins)-type glutamate (show GRIN1 Proteins) receptors, RAS-GRF1 and p38 MAP kinase (show MAPK14 Proteins).
Ras-GRF1 and -GRF2 (show RASGRF2 Proteins) may act as adaptors that bind PLCgamma1 (show PLCG1 Proteins) and restrict Ca2 (show CA2 Proteins)+ signalling to the vicinity of focal adhesions, indicating a new role for these GRFs that is required for IL-1 (show IL1A Proteins) induction of the Ras-->ERK (show EPHB2 Proteins) pathway and MMP-3 (show MMP3 Proteins) expression
identified the guanine nucleotide exchange factor Rasgrf1 as a direct Zac1/Plagl1 (show PLAGL1 Proteins) target gene in beta cells
In conclusion, our results indicated that the Rasgrf1 gene shows both species- and tissue-specific variation in imprinted expression.
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Ras-specific guanine nucleotide-releasing factor, CDC25 homolog
, Ras-specific nucleotide exchange factor CDC25
, guanine nucleotide exchange factor
, guanine nucleotide-releasing factor 1
, guanine nucleotide-releasing factor, 55 kD
, guanine nucleotide-releasing protein
, ras-specific guanine nucleotide-releasing factor 1
, GRF beta
, Ras guanine release factor beta
, guanine nucleotide releasing factor 1
, ras-specific nucleotide exchange factor CDC25
, P140 RAS-GRF
, Ras protein-specific guanine nucleotide-releasing factor 1
, ras-specific guanine nucleotide-releasing factor 1-like