This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Jun 2012].
Belichenko, Madani, Rey-Bellet, Pihlgren, Becker, Plassard, Vuillermot, Giriens, Nosheny, Kleschevnikov, Valletta, Bengtsson, Linke, Maloney, Hickman, Reis, Granet, Mlaki, Lopez-Deber, Do, Singhal et al.: "An Anti-β-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome. ..." in: PLoS ONE, Vol. 11, Issue 3, pp. e0152471, (2016) (PubMed).
Segawa, Otsuka, Itou, Suzuki, Karatani, Sakai: "Characterization of the circulating serum amyloid A in bottlenose dolphins." in: Veterinary immunology and immunopathology, Vol. 152, Issue 3-4, pp. 218-24, (2013) (PubMed).
Aliases for SAA Proteins
serum amyloid A1 (SAA1) Proteins serum amyloid A (saa) Proteins serum amyloid A protein (LOC476879) Proteins serum amyloid A1 (SAA) Proteins serum amyloid A-3 (SAA3) Proteins HPS5, biogenesis of lysosomal organelles complex 2 subunit 2 (HPS5) Proteins serum amyloid A2 (SAA2) Proteins serum amyloid A 1 (Saa1) Proteins serum amyloid A protein (LOC100270725) Proteins PIG4 Proteins SAA Proteins saa Proteins Saa-1 Proteins SAA1 Proteins SAA2 Proteins Saa2 Proteins TP53I4 Proteins zgc:103580 Proteins