Mouse anti-Human IgM (Chain mu), (Fab Region) Antibody

Catalog No. ABIN371468

Quick Overview for Mouse anti-Human IgM (Chain mu), (Fab Region) Antibody (ABIN371468)

Target: IgM

Clonality: Monoclonal

Application: Immunofluorescence (IF), Enzyme Immunoassay (EIA), Functional Studies (Func)

Clone: UHB

Isotype: IgG3

Product Details

Binding Specificity: Chain mu, Fab Region

Reactivity: Human

Host: Mouse

Purification: Purified

Application Details

Application Notes: Human B Cell Stimulation: < / = 10 μg/mL.

Other applications not tested.
Otimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.25 mg/mL

Buffer: Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -28 °C for longer.

Target Details

Target: IgM

Target Type: Antibody

Background: IgM normally constitutes about 10 % of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and is largely confined to plasma due to it's large size. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. Due to it's high valency IgM is more efficient than other isotypes is binding antigens with repeating epitopes (virus particles and red blood cells) and is more efficient than IgG in activiating the complement pathway. The gene for the mu constant region contains four domains separated by short intervening sequences. IgM measurement yields information about the body's immediate resistance and response to infection as well as information related to specific diseases. Decreased levels are associated with immune deficiency states, hereditary deficiencies, and myeloma. Increased levels can be associated with Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease.Synonyms: Human Immunoglobulin M