Goat anti-Human IgA (Free & Bound), (Secretory Component) Antibody

Catalog No. ABIN568608

Quick Overview for Goat anti-Human IgA (Free & Bound), (Secretory Component) Antibody (ABIN568608)

Target: IgA

Clonality: Polyclonal

Application: Immunoprecipitation (IP), Immunodiffusion (ID)

Product Details

Binding Specificity: Free & Bound, Secretory Component

Reactivity: Human

Host: Goat

Purification: Serum

Immunogen: Secretory component is present in human secretions bound to secretory IgA (sIgA) and in free form. Secretory IgA (sIgA) functions as a dimer or polymer and accounts for almost all specific mucosal antibody activity. A molecule of sIgA is made up of two molecules of IgA, one J chain and one SC (MW 65,000). The dimer IgA is transported into secretions by its binding to the SC on the epithelial cells. Under normal conditions, sIgA contains both subclasses IgA1 and IgA2, since both are capable of binding SC. SC also has an affinity for polymeric IgM. Purified free human secretory component isolated from pooled milk is used for immunization. Freund's complete adjuvant is used in the first step of the immunization procedure.

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Restore by adding 0.5 mLsterile distilled water. Dilutions may be prepared by adding PBS, pH 7.2

Handling Advice: Avoid repeated freezing and thawing.
Dilutions may be prepared by adding PBS, pH 7.2

Storage: 4 °C/-20 °C

Storage Comment: Prior to and following reconstitution store the antibody at 2-8 °C for one month or at -28 °C for longer.

Target Details

Target: IgA

Target Type: Antibody

Background: Synonyms: Human Immunoglobulin A