Mouse anti-Human IgD (full length) Antibody

Catalog No. ABIN7878395

Quick Overview for Mouse anti-Human IgD (full length) Antibody (ABIN7878395)

Target: IgD

Clonality: Monoclonal

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: IgD26

Isotype: IgG1, kappa

Product Details

Binding Specificity: full length

Reactivity: Human

Host: Mouse

Purpose: Human IgD Antibody / Heavy chain (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: Full length recombinant human IGHD protein was used as the immunogen for the human IgD antibody.

Application Details

Application Notes: Optimal dilution of the human IgD antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the human IgD antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details

Target: IgD

Target Type: Antibody

Background: Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through interchain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin D (IgD) exists as a monomer with light chains. It plays a biological role as a transmembrane receptor molecule, co-expressed with IgM on the surface of mature/naive B cells. In particular, it is found on spleen B cell surfaces. Compared to IgM, IgD exists in much lower numbers and is not expressed on immature B cells. IgD surface expression on B cells is regulated in part by IL-27. In mice, the inhibition of this immunoglobulin isotype does not cause a significant change to the immune system.

UniProt: P01880