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These data indicate that the coordinated, temporal ordering of cyclin F (show CCNF Proteins) and Cdh1 degradation, organized in a double-negative feedback loop, represents a fundamental aspect of cell-cycle control
PARP3 (show PARP3 Proteins) controls of TGFbeta (show TGFB1 Proteins)-induced epithelial mesenchymal transformation and acquisition of stem-like cell features by stimulation transglutaminase 2 (show TGM2 Proteins)/SNAI1 (show SNAI1 Proteins) signaling.
cryo-EM structure of an APC (show APC Proteins)/C-Cdh1 complex with Apc1 (show SLC25A24 Proteins)(WD40 (show DCAF12L2 Proteins)) deleted showed that the mutant APC (show APC Proteins)/C is locked into an inactive conformation in which the UbcH10 (show UBE2C Proteins)-binding site of the catalytic module is inaccessible. Additionally, an EM density for Apc15 (show ANAPC15 Proteins) is not visible
FDG (show SMUG1 Proteins) uptake on PET was associated with negative E-cadherin expression in patients with lung adenocarcinoma.
Heterozygosity and mutant homozygosity as well as the combination of both TP53 (show TP53 Proteins) Arg72Pro and CDH1 rs16260 polymorphisms are responsible to increase the risk of colorectal cancer development in Bangladeshi population.
Combining the targets E-cadherin, epithelial membrane antigen (EMA (show ETFA Proteins)), human epidermal growth receptor type 2 (Her2/neu (show ERBB2 Proteins)), carcinoembryonic antigen (CEA (show CEACAM5 Proteins)) resulted in nearly 100% detection of ductal ovarian metastases, whereas the combination of EMA (show ETFA Proteins), Her2/neu (show ERBB2 Proteins) and epithelial cell adhesion molecule (EpCAM (show EPCAM Proteins)) was most suitable to detect lobular ovarian metastases.
analysis of a novel SMAD (show SMAD1 Proteins)-independent pathway linking enhanced activin B signaling to reduced E-cadherin expression and increased migration in type II endometrial cancer
Data indicate that CDH11, ICAM1 (show ICAM1 Proteins) and CLDN3 (show CLDN3 Proteins) were overexpressed in tumors when compared to normal esophagus, normal gastric and non-dysplastic Barrett's.
The combined biomarkers E-cadherin, membranous epidermal growth factor receptor (EGFR (show EGFR Proteins)) and vimentin (show VIM Proteins) show a stronger prognostic value for and disease-free survival than any of the single biomarkers.
aberrant Notch1 (show NOTCH1 Proteins) is linked to hepatocellular carcinoma development, tumor recurrence and invasion, which might be mediated, at least in part, through the Notch1 (show NOTCH1 Proteins)-E-Cadherin pathway
These results provide the first in vivo evidence that Flotillins regulate E-cadherin-mediated cell-cell junctions to allow epiboly progression.
These collective findings indicate that loss of Bit1 (show PTRH2 Proteins) expression contributes to the acquisition of malignant phenotype of human lung epithelial cells via Erk (show MAPK1 Proteins) activation-induced suppression of E-cadherin expression.
In zebrafish, E-cadherin is expressed in lens epithelium, whereas N-cadherin (show CDH2 Proteins) is required for lens fiber growth
These data indicate that emi1 (show FBXO5 Proteins) deficiency-induced defects in vivo are due to the dysregulation of an APC/C-Cdh1 molecular axis.
without Chp (show CHP Proteins) signaling, E-cadh shifts to intracellular vesicles rather than the adhesive contacts needed for directed cell movement during epiboly
Downregulation of E-cadherin gene may cause omphalocele in the Cd chick model by disrupting CRT (show CALR Proteins)-mediated Ca(2 (show CA2 Proteins)+) signaling and AJs.
analyzed expression patterns of three zebrafish classical (type I) cadherins (cadherin-1, -2, and -4) in the embryonic zebrafish cranial ganglia and lateral line system
cadherin-1 is detected in the epidermis of the embryonic limb buds and the larval pectoral fins of zebrafish
hab/E-cadherin is necessary for the cell rearrangements that spread the teleost blastoderm over the yolk
Lgl2 (show LLGL2 Proteins) and E-cadherin act antagonistically to control the localisation of integrin alpha 6 (show ITGA6 Proteins) during the formation of hemidesmosomes in the developing epidermis
E-cadherin mRNA/protein were up-regulated in all flutamide-treated corpus luteum of mid- and late pregnancy.
In pig kidney, strong E-cadherin expression was observed in the basolateral plasma membrane of the tubular epithelial cells. E-cadherin immunolabeling was not detected in glomeruli or blood vessels of pig kidney.
Localisation of NANOG (show NANOG Proteins), OCT4 (show POU5F1 Proteins), and E-CADHERIN in porcine pre- and peri (show PLIN1 Proteins)-implantation embryos.
The epiblast expressed epithelial markers, MUC1 (show MUC1 Proteins) and E-CADHERIN, and the pluripotency markers, DNMT3B (show DNMT3B Proteins) and CRIPTO (show TDGF1 Proteins).
JNK deficient embryos also have increased intercellular adhesion and defects in e-cadherin localization. Conversely, embryos with overactive JNK have epidermal fragility, increased E-cadherin internalization, and increased membrane localized clathrin.
the switch from E- to N-cadherin (show CDH2 Proteins) during epithelial-mesenchymal transition is essential for acquisition of Contact inhibition of locomotion behavior.
Study shows that over time, epithelial tumor cells undergo epithelial state to a mesenchymal-like state changes (including loss of E-cadherin expression) during primary tumor growth and E-cadherin is re-expressed in metastatic tumor cells.
This study reveals a novel role for Cdh1 in craniofacial development through promoting APC (show APC Proteins)-dependent non-proteolytic ubiquitination and activation of Gsc (show GSC Proteins).
Neutrophil elastase has the capacity to cleave E-cad and interfere with its cell-cell adhesion function in acutely injured lung epithelium.
We describe a mouse model in which inducible deletion of E-cadherin in prostate luminal cells results in their apoptotic cell death by anoikis, in the absence of phenotypic effects in the surrounding stroma
Our results provide a mechanistic explanation for the spontaneous emergence of pluripotent cells from GSC (show GSC Proteins) cultures; namely, rare GSCs upregulate CDH1 and initiate MET, processes normally kept in check by ZEB1 and TGF-beta (show TGFB1 Proteins) signaling, thereby ensuring germ cells are protected from aberrant acquisition of pluripotency.
PTEN loss in E-cadherin-deficient mouse mammary epithelial cells rescues apoptosis and results in development of classical invasive lobular carcinoma.
Low CDH1 expression is associated with Gastric Tumorigenesis.
These observations highlight the relevance of APC (show APC Proteins)/C cofactor Cdh1 activity during G1 to ensure an adequate supply of deoxynucleoside triphosphates to the replisome, prevent replication stress and the resulting chromosomal breaks and, ultimately, suppress tumorigenesis.
Ilk (show ILK Proteins) and ELMO2 (show ELMO2 Proteins) modulate recycling endosomes in keratinocytes undergoing intercellular adhesion mediated through cell-cell contacts, including E-cadherin-based adherens junctions.
JNK (show MAPK8 Proteins) signaling, which is inversely correlated with WNT4 (show WNT4 Proteins), plays an important role in perinatal germline cyst breakdown and primordial follicle formation by regulating E-cadherin junctions between oocytes in mouse ovaries.
Transfection of zygotes with 100 and 200 nM E-cadherin siRNA led to a 72 and 38% reduction, respectively, in E-cadherin mRNA relative abundance in Day 7 blastocysts compared with controls.
E-cadherin and beta-catenin (show CTNNB1 Proteins) were distributed not only at the cell to cell boundary but throughout the cytoplasm in binucleate trophoblast cells
Results describe the effect of suppression of connexin 43 (show GJA1 Proteins) and E-cadherin on the development, mRNA and protein expression of bovine blastocysts cultured in vitro or in vivo.
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.
, cadherin 1, E-cadherin (epithelial)
, calcium-dependent adhesion protein, epithelial
, cell-CAM 120/80
, epithelial cadherin
, hypothetical protein LOC368517
, cadherin 1, epithelial
, half baked
, cadherin 1, type 1, E-cadherin (epithelial)
, liver cell adhesion molecule
, liver cell adhesion protein
, Epithelial cadherin