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anti-Human HOXA1 Antibodies:
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Human Polyclonal HOXA1 Primary Antibody for IF, WB - ABIN516595
Scott, Nogueira, Heffernan, van Doorn, Dhakal, Hanna, Min, Jaskelioff, Xiao, Wu, Cameron, Perry, Zeid, Feinberg, Kim, Vande Woude, Granter, Bosenberg, Chu, DePinho, Rimm, Chin: Proinvasion metastasis drivers in early-stage melanoma are oncogenes. in Cancer cell 2011
Human Polyclonal HOXA1 Primary Antibody for ELISA, WB - ABIN4319684
Chakrabarti, Dudbridge, Kent, Wheelwright, Hill-Cawthorne, Allison, Banerjee-Basu, Baron-Cohen: Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. in Autism research : official journal of the International Society for Autism Research 2009
We speculate that HOXA1 may be the direct target of miR181b5p or miR181d5p in LUSC, and HOXA1 may serve a significant role in nonsmall cell lung cancer (NSCLC) by regulating various pathways, particularly the p53 (show TP53 Antibodies) signaling pathway.
Study revealed the existence of negative correlation between the expression of miR577 and HOXA1 in hepatocellular carcinoma (HCC (show FAM126A Antibodies)) specimens. HOXA1 expression is under the direct regulation of miR577 which is able to bind to its 3'UTR (show UTS2R Antibodies).
HOTTIP cooperates with CTCF (show CTCF Antibodies) to coordinate HOXA gene expression.
that miR (show MLXIP Antibodies)-433 was frequently downregulated in colon cancer tissues and cell lines. Overexpression of miR (show MLXIP Antibodies)-433 significantly inhibited the proliferation and invasion of colon cancer. We also newly identified HOXA1 as a direct target of miR (show MLXIP Antibodies)-433. The effects of miR (show MLXIP Antibodies)-433 on colon cancer cells were mediated via HOXA1.
we found that KDM3B (show KDM3B Antibodies) exhibits potential tumor-suppressive activity and transcriptionally modulates HOXA1 expression via RARE in AML (show RUNX1 Antibodies).
miR (show MLXIP Antibodies)-30c could suppress giant cell tumor of bone cell proliferation and progression via HOXA1, which might provide a new target for giant cell tumor of bone diagnosis and therapy
UBE2C (show UBE2C Antibodies) and HOXA1 RNA and protein are differentially expressed in conventional and Spitz nevi and melanoma.
Study identified HOXA1 as a direct target of miR (show MLXIP Antibodies)-30e. Its expression is down-regulated by miR (show MLXIP Antibodies)-30e played leading to suppressed lung cancer cell growth.
HOXA1-mediated activation of NF-kappaB (show NFKB1 Antibodies) is non-transcriptional and the RBCK1 (show RBCK1 Antibodies) and TRAF2 (show TRAF2 Antibodies) influences on NF-kappaB (show NFKB1 Antibodies) are epistatic to HOXA1
Overexpression of the HOXA1 expression is associated with increased transformation of myelodysplastic syndrome into acute myeloid leukemia (show BCL11A Antibodies).
When Hoxa1, Hoxb1 (show HOXB1 Antibodies) and Hoxd1 (show HOXD1 Antibodies) are knocked down in combination, the hindbrain patterning phenotype is more severe than in the single or double knockdowns
we provide evidence that HOXA1 displays an unexpectedly long half-life and demonstrate that PRDM14 (show PRDM14 Antibodies) can reduce the stability and affect the transcriptional activity of HOXA1.
Proteomic analyses show that HOXA1 physically interacts on chromatin with PBX, MEIS, and PREP (show PREP Antibodies) family members, but not with TGIF (show TGIF1 Antibodies), suggesting that TGIF (show TGIF1 Antibodies) may have an independent input into HOXA1-bound regions.This study provides new insight into a regulatory network involving combinatorial interactions between HOXA1 and TALE proteins
Hoxa1 and Hoxb1 are required for pharyngeal arch artery development.
Authors found evidence for a high degree of evolutionary conservation of many binding regions and downstream targets of Hoxa1 between mouse and zebrafish.
Data indicate that homeobox A1 (HOXA1) was a direct microRNA miR (show MLXIP Antibodies)-30b target in esophageal cancer (EC) cells.
In presence of these inducing agents, lipid accumulation as well as expression of HoxA1, HoxA5 (show HOXA5 Antibodies), HoxC4 (show HOXC4 Antibodies) &HoxC8 (show HOXC8 Antibodies) markedly enhanced. Irrespective of presence or absence of T3, insulin (show INS Antibodies) down regulates HoxA10 (show HOXA10 Antibodies). T3 results in over expression of HoxA5 (show HOXA5 Antibodies), HoxC4 (show HOXC4 Antibodies) and HoxC8 (show HOXC8 Antibodies) genes, whereas insulin (show INS Antibodies) up regulates expression of only HoxC8 (show HOXC8 Antibodies)
These data suggest that Hoxb1 (show HOXB1 Antibodies) and Hoxa1 are more phenotypically divergent than previously reported and support that sub- and/or neofunctionalization has occurred in these paralogous genes leading to a divergence of gene function and incomplete redundancy
YAP regulates the expression of Hoxa1 and Hoxc13 in oral and dental epithelial tissues as well as in the epidermis of skin during embryonic and adult stages.
Many Hoxa1 interactors are proteins involved in cell-signaling transduction, cell adhesion and vesicular trafficking.
Hoxa1 null mice show defects such as interrupted aortic arch, aberrant subclavian artery and Tetralogy of Fallot mimic the defects in HoxA1 syndrome patients.
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. Two transcript variants encoding two different isoforms have been found for this gene, with only one of the isoforms containing the homeodomain region.
HOX A1 homeodomain protein
, Hox 1.6-like protein
, homeo box A1
, homeobox 1F
, homeobox protein Hox-1F
, homeobox protein Hox-A1
, lab-like protein
, homeobox A1
, homeobox A1, isoform 1
, early retinoic acid 1
, homeobox protein Hox-1.6
, homeoboxless protein ERA-1-399
, homeotic protein ERA-1-993
, homeobox protein