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anti-Human HOXA1 Antibodies:
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Human Polyclonal HOXA1 Primary Antibody for ELISA, WB - ABIN4319684
Chakrabarti, Dudbridge, Kent, Wheelwright, Hill-Cawthorne, Allison, Banerjee-Basu, Baron-Cohen: Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. in Autism research : official journal of the International Society for Autism Research 2009
Human Polyclonal HOXA1 Primary Antibody for IF, WB - ABIN516595
Scott, Nogueira, Heffernan, van Doorn, Dhakal, Hanna, Min, Jaskelioff, Xiao, Wu, Cameron, Perry, Zeid, Feinberg, Kim, Vande Woude, Granter, Bosenberg, Chu, DePinho, Rimm, Chin: Proinvasion metastasis drivers in early-stage melanoma are oncogenes. in Cancer cell 2011
Results find that HOXA1 expression is regulated in glioblastoma multiforme by HOTAIRM1 which decreases DNA methylation levels in the HOXA1 promoter region by reducing DNA methyltransferases.
We speculate that HOXA1 may be the direct target of miR181b5p or miR181d5p in LUSC, and HOXA1 may serve a significant role in nonsmall cell lung cancer (NSCLC) by regulating various pathways, particularly the p53 signaling pathway.
Study revealed the existence of negative correlation between the expression of miR577 and HOXA1 in hepatocellular carcinoma (HCC) specimens. HOXA1 expression is under the direct regulation of miR577 which is able to bind to its 3'UTR.
HOTTIP cooperates with CTCF to coordinate HOXA gene expression.
that miR-433 was frequently downregulated in colon cancer tissues and cell lines. Overexpression of miR-433 significantly inhibited the proliferation and invasion of colon cancer. We also newly identified HOXA1 as a direct target of miR-433. The effects of miR-433 on colon cancer cells were mediated via HOXA1.
we found that KDM3B exhibits potential tumor-suppressive activity and transcriptionally modulates HOXA1 expression via RARE in AML.
miR-30c could suppress giant cell tumor of bone cell proliferation and progression via HOXA1, which might provide a new target for giant cell tumor of bone diagnosis and therapy
UBE2C and HOXA1 RNA and protein are differentially expressed in conventional and Spitz nevi and melanoma.
Study identified HOXA1 as a direct target of miR-30e. Its expression is down-regulated by miR-30e played leading to suppressed lung cancer cell growth.
HOXA1-mediated activation of NF-kappaB is non-transcriptional and the RBCK1 and TRAF2 influences on NF-kappaB are epistatic to HOXA1
Overexpression of the HOXA1 expression is associated with increased transformation of myelodysplastic syndrome into acute myeloid leukemia.
Data indicated that HOXA1 and CCND1 mRNA and protein expression were higher in gastric cancer (GC) tissues, that a significant correlation was found between their expression, and they both may serve as a novel prognostic biomarker for GC.
MicroRNA-99a inhibits tumor aggressive phenotypes through regulating HOXA1 in breast cancer cells.
In a Middle Eastern population, HOXA1 is not likely a common cause of non-syndromic deafness.
our findings suggest that HOXA1 is involved in the regulation of prostate cancer progression, including cell growth, migration, invasion and metastasis
Studied HOTAIR in chemoresistance of SCLC and possible molecular mechanism. Knockdown of HOTAIR was carried out in SCLC multidrug-resistant cell lines; found depletion of HOTAIR reduced HOXA1 methylation by decreasing DNMT1 & DNMT3b expression.
YAP regulates the expression of HOXA1 and HOXC13 in human keratinocytes.
Analysis indicates that the genes BIRC5, HOXA1 and RARB are critical targets that play an important regulatory role in cervical cancer pathogenesis.
ACK1 interacts with KDM3A to regulate the mammary tumor oncogene HOXA1.
MicroRNA-99 family members suppress Homeobox A1 expression in epithelial cells.
When Hoxa1, Hoxb1 and Hoxd1 are knocked down in combination, the hindbrain patterning phenotype is more severe than in the single or double knockdowns
we provide evidence that HOXA1 displays an unexpectedly long half-life and demonstrate that PRDM14 can reduce the stability and affect the transcriptional activity of HOXA1.
Proteomic analyses show that HOXA1 physically interacts on chromatin with PBX, MEIS, and PREP family members, but not with TGIF, suggesting that TGIF may have an independent input into HOXA1-bound regions.This study provides new insight into a regulatory network involving combinatorial interactions between HOXA1 and TALE proteins
Hoxa1 and Hoxb1 are required for pharyngeal arch artery development.
Authors found evidence for a high degree of evolutionary conservation of many binding regions and downstream targets of Hoxa1 between mouse and zebrafish.
Data indicate that homeobox A1 (HOXA1) was a direct microRNA miR-30b target in esophageal cancer (EC) cells.
In presence of these inducing agents, lipid accumulation as well as expression of HoxA1, HoxA5, HoxC4 &HoxC8 markedly enhanced. Irrespective of presence or absence of T3, insulin down regulates HoxA10. T3 results in over expression of HoxA5, HoxC4 and HoxC8 genes, whereas insulin up regulates expression of only HoxC8
These data suggest that Hoxb1 and Hoxa1 are more phenotypically divergent than previously reported and support that sub- and/or neofunctionalization has occurred in these paralogous genes leading to a divergence of gene function and incomplete redundancy
YAP regulates the expression of Hoxa1 and Hoxc13 in oral and dental epithelial tissues as well as in the epidermis of skin during embryonic and adult stages.
Many Hoxa1 interactors are proteins involved in cell-signaling transduction, cell adhesion and vesicular trafficking.
Hoxa1 null mice show defects such as interrupted aortic arch, aberrant subclavian artery and Tetralogy of Fallot mimic the defects in HoxA1 syndrome patients.
Hoxa1 acts in a genetic cascade upstream of genes controlling specific aspects of embryonic development.
Hoxa1 lineage tracing uncovered new domains of Hoxa1 expression in rhombomere 3, the otic epithelium, and cardiac precursors, suggesting a more direct role for Hoxa1 in development of these tissues than previously believed.
HOXA1 is a mammary epithelial oncogene with aggressive in vivo tumor formation
results describe the functional requirements in hindbrain neuronal patterning that follow the establishment of the genetic regulatory hierarchy between Hoxa1, Hoxb1 and Hoxb2
mediates repression of endodermal differentiation while promoting expression of ectodermal and mesodermal characteristics
The newly generated autoregulatory Hoxa1 gene can deliver the functionality of both paralogs in these mice, providing normal viability as well as proper facial nerve formation even in the Hoxb1 mutant background.
Hoxa1 activity is essential for the neuronal differentiation of embryonic stem cells
Hoxa1-399 reduces Hoxa1-993/Pbx1 binding to the Hoxb1 SOct-R3 region
Plays a vital role in the generation of neural crest cells.
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. Two transcript variants encoding two different isoforms have been found for this gene, with only one of the isoforms containing the homeodomain region.
HOX A1 homeodomain protein
, Hox 1.6-like protein
, homeo box A1
, homeobox 1F
, homeobox protein Hox-1F
, homeobox protein Hox-A1
, lab-like protein
, homeobox A1
, homeobox A1, isoform 1
, early retinoic acid 1
, homeobox protein Hox-1.6
, homeoboxless protein ERA-1-399
, homeotic protein ERA-1-993
, homeobox protein