Browse our anti-Purinergic Receptor P2X, Ligand Gated Ion Channel 2 (P2RX2) Antibodies

Human Purinergic Receptor P2X, Ligand Gated Ion Channel 2 (P2RX2) interaction partners

1. identified P2RX2, KCNQ5, ERBB3 and SOCS3 to be associated with the progression of age-related hearing impairment

2. These findings indicate that the CaMKII-mediated GluA1 phosphorylation of S567 and S831 is critical for P2X2-mediated AMPAR internalization and ATP-driven synaptic depression.

3. Data show that monoclonal antibodies directed against human P2X3 (12D4) potentiated the slow inactivating current mediated by the heteromeric purinergic receptor hP2X2/3 channel.

4. Results demonstrate that the stoichiometry of the heterotrimeric hP2X2/3 receptor is not fixed, but determined by the relative availability of P2X2 and P2X3 subunits

5. The results from this study demonstrate that there is a significant difference in the expression of the purinergic P2X2, P2X3 and P2X7 receptors in the different histological layers of the human urinary bladder.

6. A novel mutation in the P2RX2 gene was identified in a MELAS family.

7. The locus designated DFNA41 maps to a 15 cM region on chromosome 12q24.32-qter, proximal to the marker D12S1609.

8. Molecular analyses of P2RX2 identified a novel missense mutation.

9. Data indicate that the P2X2(I328C) receptor was activated by propyl-methanethiosulfonate (MTS) as effectively as by ATP.

10. Data indicate that MgATP2- activates P2X1 and P2X3, but not P2X2 and P2X4 receptors.

11. the contribution of the extracellular, transmembrane, and intracellular segments to recovery from desensitization

12. analysis of dominantly inherited, progressive sensorineural hearing loss DFNA41 in a six-generation kindred revealed a rare heterozygous allele, P2RX2 c.178G > T (p.V60L), at chr12:133,196,029, which cosegregated with fully penetrant hearing loss

13. trimeric P2X receptors containing only two intact binding sites can be readily activated by ATP.

14. High potency zinc modulation of human P2X2 receptors and low potency zinc modulation of rat P2X2 receptors share a common molecular mechanism

15. one subunit of P2X2 and two subunits of P2X3 form P2X2/3 heteromeric receptors, whereas two subunits of P2X2 and one subunit of P2X6 constitute P2X2/6 receptors

16. Studies indicate that P2X1, P2X2, and P2X4 receptors are detected in preglomerular microvessels.

17. analysis of agonists trapped in ATP-binding sites of the P2X2 receptor

18. GABA(A) receptor dynamics are regulated by interaction with purinergic P2X(2) receptors

19. Data suggest that interactions between alpha3beta4 nAChRs and P2X2 receptors may modulate transmission at enteric synapses that use ATP and acetylcholine as co-transmitters.

20. Lipid raft association and cholesterol sensitivity of P2X1-4 receptors for ATP

Mouse (Murine) Purinergic Receptor P2X, Ligand Gated Ion Channel 2 (P2RX2) interaction partners

1. P2X2 receptors are mainly localized in the supporting cells of the vestibular inner ear, and loss of P2X2 receptors causes mild vestibular dysfunction.

2. These results indicate that the P2X2aR is a novel target for Cdk5-mediated phosphorylation, which might play important physiological roles including pain signaling.

3. results indicate that the lateral border of the P2X2 terminal field, demarcates a faithful "transition zone," where AO responses transition from gustatory to mechanosensory

4. may be involved in skeletal pain due to high bone turnover

5. Obesity promotes down regulation of P2rx2 receptor expression in enteric neurons innervating the ileum.

6. This study observed maltodextrin and fat preference deficits in "taste-blind" P2X2/P2X3 knockout mice.

7. Purinergic signaling is important for cell fate determination during neural differentiation, with P2X2 and P2X7 receptors promoting neurogenesis and gliogenesis, respectively.

8. results show that sufficient endogenous ATP is released by bursts of action potentials to act at P2X2 receptors to modulate neuropeptide release.

9. P2X2 is expressed in WT taste buds and appears to function as an autocrine, positive feedback signal to amplify taste-evoked ATP secretion.

10. ATP-induced current on mouse spermatozoa is mediated by the P2X2 purinergic receptor/channel.

11. GABA(A) receptor dynamics are regulated by interaction with purinergic P2X(2) receptors

12. Transcripts for P2X2 were present in nearly all colon neurons examined.

13. Review illustrates how density-dependent changes in the P2X2 receptor pore properties have potential implications for physiological regulation by changing the local density of the channel at a synapse and in turn the dynamic properties of the synapse.

14. Data suggest that double P2X2/P2X3 purinergic receptor knockout mice are unable to respond to NaCl or the artificial sweetener SC45647 as taste stimuli, mirroring the lack of gustatory nerve responses to these substances.

15. In brief access tests, double P2X2/P2X3 purinergic receptor null mice avoided citric acid and hydrochloric acid at the same concentrations as their wild-type counterparts, indicating that these weak acids activate oropharyngeal chemoreceptors.

16. heteromeric receptors formed by distinct P2XR subunits develop new functions resulting from integrative effects of the participating extracellular and C-terminal subdomains

17. P2X(2) purine receptor immunoreactivity is a feature of intraganglionic laminar endings in the mouse, and that P2X receptor agonists may modulate sensitivity of the intraganglionic laminar endings

18. P2X2 homomeric receptors contribute to fEPSPs in neural pathways underlying peristalsis studied in vitro.

19. P2X2 receptor subunit play a pivotal role in carotid body function and in mediating ventilatory responses to hypoxia.

20. Presence of homomeric P2X2 receptor is demonstrated for the first time in mouse otic neurons.