Browse our anti-Purinergic Receptor P2X, Ligand Gated Ion Channel 2 (P2RX2) Antibodies

Human Purinergic Receptor P2X, Ligand Gated Ion Channel 2 (P2RX2) interaction partners

1. identified P2RX2, KCNQ5 (show KCNQ5 Antibodies), ERBB3 (show ERBB3 Antibodies) and SOCS3 (show SOCS3 Antibodies) to be associated with the progression of age-related hearing impairment

2. These findings indicate that the CaMKII (show CAMK2G Antibodies)-mediated GluA1 (show GRIA1 Antibodies) phosphorylation of S567 and S831 is critical for P2X2-mediated AMPAR internalization and ATP-driven synaptic depression.

3. Data show that monoclonal antibodies directed against human P2X3 (show P2RX3 Antibodies) (12D4) potentiated the slow inactivating current mediated by the heteromeric purinergic receptor (show P2RX1 Antibodies) hP2X2/3 channel.

4. Results demonstrate that the stoichiometry of the heterotrimeric hP2X2/3 receptor is not fixed, but determined by the relative availability of P2X2 and P2X3 (show P2RX3 Antibodies) subunits

5. The results from this study demonstrate that there is a significant difference in the expression of the purinergic P2X2, P2X3 (show P2RX3 Antibodies) and P2X7 (show P2RX7 Antibodies) receptors in the different histological layers of the human urinary bladder.

6. A novel mutation in the P2RX2 gene was identified in a MELAS family.

7. Molecular analyses of P2RX2 identified a novel missense mutation.

8. Data indicate that the P2X2(I328C) receptor was activated by propyl-methanethiosulfonate (MTS (show TIMM8A Antibodies)) as effectively as by ATP.

9. Data indicate that MgATP2- activates P2X1 (show P2RX1 Antibodies) and P2X3 (show P2RX3 Antibodies), but not P2X2 and P2X4 (show P2RX4 Antibodies) receptors.

10. analysis of dominantly inherited, progressive sensorineural hearing loss DFNA41 in a six-generation kindred revealed a rare heterozygous allele, P2RX2 c.178G > T (p.V60L), at chr12:133,196,029, which cosegregated with fully penetrant hearing loss

Mouse (Murine) Purinergic Receptor P2X, Ligand Gated Ion Channel 2 (P2RX2) interaction partners

1. These results indicate that the P2X2aR is a novel target for Cdk5 (show CDK5 Antibodies)-mediated phosphorylation, which might play important physiological roles including pain signaling.

2. results indicate that the lateral border of the P2X2 terminal field, demarcates a faithful "transition zone," where AO responses transition from gustatory to mechanosensory

3. Obesity promotes down regulation of P2rx2 receptor expression in enteric neurons innervating the ileum.

4. This study observed maltodextrin and fat preference deficits in "taste-blind" P2X2/P2X3 (show P2RX3 Antibodies) knockout mice.

5. Purinergic signaling is important for cell fate determination during neural differentiation, with P2X2 and P2X7 (show P2RX7 Antibodies) receptors promoting neurogenesis and gliogenesis, respectively.

6. results show that sufficient endogenous ATP is released by bursts of action potentials to act at P2X2 receptors to modulate neuropeptide release.

7. P2X2 is expressed in WT taste buds and appears to function as an autocrine, positive feedback signal to amplify taste-evoked ATP secretion.

8. ATP-induced current on mouse spermatozoa is mediated by the P2X2 purinergic receptor/channel.

9. Transcripts for P2X2 were present in nearly all colon neurons examined.

10. Review illustrates how density-dependent changes in the P2X2 receptor pore properties have potential implications for physiological regulation by changing the local density of the channel at a synapse and in turn the dynamic properties of the synapse.