P2RX2 antibody (AA 139-471)

Catalog No. ABIN3043588

This Rabbit Polyclonal antibody specifically detects P2RX2 in WB and IHC. It exhibits reactivity toward Human, Mouse and Rat. It has been mentioned in 2+ publications

Quick Overview for P2RX2 antibody (AA 139-471) (ABIN3043588)

Target: P2RX2 (Purinergic Receptor P2X, Ligand Gated Ion Channel 2 (P2RX2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This P2RX2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-P2RX2 Antibody

Binding Specificity: AA 139-471

Purpose: Anti-P2X2/P2RX2 Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-P2X2/P2RX2 Antibody (ABIN3043588). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human P2X2 recombinant protein (Position: D139-L471). Human P2X2 shares 84% amino acid (aa) sequence identity with both mouse and rat P2X2.

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

References for anti-P2RX2 antibody (ABIN3043588)

Meng, Zheng, Yan, Li, Fang, Li: "P2X2 and P2X5 Receptors Mediate Bladder Hyperesthesia in ICC in Female Overactive Bladder." in: Cell biochemistry and biophysics, Vol. 72, Issue 2, pp. 375-83, (2016) (PubMed).

Lin, Li, Den, Xu, Liu, Gao, Liu, Zhang, Li, Liang: "VEGF and its receptor-2 involved in neuropathic pain transmission mediated by P2X?(/)? receptor of primary sensory neurons." in: Brain research bulletin, Vol. 83, Issue 5, pp. 284-91, (2010) (PubMed).

Target Details for P2RX2

Target: P2RX2 (Purinergic Receptor P2X, Ligand Gated Ion Channel 2 (P2RX2))

Alternative Name: P2RX2

Background:

Synonyms: P2X purinoceptor 2,P2X2,ATP receptor,Purinergic receptor,P2RX2,P2X2,

Background: The P2RX2 gene encodes the P2X2 receptor, which assembles as a trimer to form a ligand-gated ion channel gated by extracellular ATP. P2X2 receptors mediate a variety of cellular responses, including excitatory postsynaptic responses in sensory neurons. The product of this gene belongs to the family of purinoceptors for ATP. P2RX2 is mapped to 12q24.33. It has been found that ATP-activated P2RX2 influenced OHC electromotility, a stimulus-induced change in hair cell length that functions as an amplifier to determine hearing sensitivity and frequency selectivity. What's more, P2RX2 channels were necessary for development of the temporary threshold shift.

Sequence Similarities: Belongs to the P2X receptor family.

Molecular Weight: 60 kDa

Gene ID: 22953

Pathways: Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity