(Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
signal transducer and activator of transcription 1 (STAT1) Proteins signal transducer and activator of transcription 1 (Stat1) Proteins signal transducer and activator of transcription 1 L homeolog (stat1.L) Proteins signal transducer and activator of transcription 1, 91kDa (STAT1) Proteins signal transducer and activator of transcription 4 (stat4) Proteins signal transducer and activator of transcription 1a (stat1a) Proteins 2010005J02Rik Proteins AA408197 Proteins CANDF7 Proteins DD6G4-4 Proteins dZ182H3.3 Proteins ISGF-3 Proteins si:by51f19.1 Proteins si:by134g18.2 Proteins si:dz73o4.2 Proteins si:dz182h3.3 Proteins si:dz199m19.1 Proteins STAT Proteins STAT1 Proteins stat1 Proteins STAT4 Proteins STAT91 Proteins XStat1 Proteins