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Human Polyclonal PROX1 Primary Antibody for IF, WB - ABIN1589859
Quagliata, Klusmeier, Cremers, Pytowski, Harvey, Pettis, Thiele, Sleeman: Inhibition of VEGFR-3 activation in tumor-draining lymph nodes suppresses the outgrowth of lymph node metastases in the MT-450 syngeneic rat breast cancer model. in Clinical & experimental metastasis 2014
Show all 9 Pubmed References
Human Polyclonal PROX1 Primary Antibody for WB - ABIN1881686
Nagai, Li, Hatano, Toshihito, Yuge, Ito, Utsumi, Saito, Kinoshita: Mutations and aberrant DNA methylation of the PROX1 gene in hematologic malignancies. in Genes, chromosomes & cancer 2003
Show all 4 Pubmed References
Human Polyclonal PROX1 Primary Antibody for ICC, IF - ABIN4347959
Abdolazimi, Stojanova, Segil: Selection of cell fate in the organ of Corti involves the integration of Hes/Hey signaling at the Atoh1 promoter. in Development (Cambridge, England) 2016
Show all 2 Pubmed References
Human Monoclonal PROX1 Primary Antibody for ICC, IF - ABIN2668929
Chen, Patel, Cain, Duncan: Production of monoclonal antibodies against Prox1. in Hybridoma (2005) 2006
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Human Polyclonal PROX1 Primary Antibody for IF, IHC (p) - ABIN929458
Kulkarni, Herman, Ikegami, Greenberg, Akeson: Lymphatic ontogeny and effect of hypoplasia in developing lung. in Mechanisms of development 2011
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Chicken Monoclonal PROX1 Primary Antibody for CyTOF, ELISA - ABIN447455
Sweat, Sloas, Murfee: VEGF-C induces lymphangiogenesis and angiogenesis in the rat mesentery culture model. in Microcirculation (New York, N.Y. : 1994) 2014
PROX1 is a new prognostic biomarker for 1p19q non-codeleted high-grade astrocytomas that have progressed from pre-existing low-grade tumors and harbor IDH mutations.
ERbeta (show ESR2 Antibodies) in both normal and cancerous colon epithelial cells upregulates miRNA-205, which subsequently reduces PROX1 through direct interaction with its 3'UTR (show UTS2R Antibodies)
The aim of this study was to examine the association between HHEX (show HHEX Antibodies) (rs5015480) and PROX1 (rs340874) gene polymorphisms and Gestational diabetes mellitus (GDM) .Despite these associations, PROX1 gene variants were not previously examined in women with GDM; however, our results suggest a lack of such an association.
PROX1 overexpression in DAB2IP-deficient prostate cancer cells could enhance the accumulation of HIF1alpha protein by inhibiting ubiquitin pathway and then consequently induce an epithelial-mesenchymal transition response.
study achieved a long-lasting expression of Prox1 in lymphatic endothelial-like cells, and it provided a potentially useful approach for developing novel therapies for limb lymphedema and lymphatic system-related diseases
In gastric cancer, high cytoplasmic PROX1 expression is an independent marker of better prognosis.
High PROX1 and beta-catenin (show CTNNB1 Antibodies) expression were independent factors for better prognosis in pancreatic ductal adenocarcinoma.
Data suggest that DBC1 has a dual function in regulating beta-catenin (show CTNNB1 Antibodies)-PROX1 signaling axis: as a coactivator for both beta-catenin (show CTNNB1 Antibodies) and PROX1.
PROX1 gene is a strong candidate of early onset of diabetes with variations depending on ethnicity.
We also discovered and replicated three genome-wide significant variants in previously unreported loci for RDW (SLC12A2 (show SLC12A2 Antibodies) rs17764730, PSMB5 (show PSMB5 Antibodies) rs941718), and hematocrit (PROX1 rs3754140) and an upstream anti-sense long-noncoding RNA, LINC01184, as the likely causal variant
PROX1 (show C16orf35 Antibodies) controls expression of genes regulating lipid homeostasis.HDAC3 interacts with PROX1 (show C16orf35 Antibodies).
the neurogenic and oligodendrogliogenic lineages in the two adult neurogenic niches exhibit a distinct requirement for Prox1 (show C16orf35 Antibodies).
Our study demonstrates that Prox1 (show C16orf35 Antibodies)-GFP/Flk1 (show KDR Antibodies)::myr-mCherry mice are a useful model for studying coordinated hemangiogenic and lymphangiogenic responses
Prox1 (show C16orf35 Antibodies) was first expressed in all developing neurons, followed by a decrease in type II primary auditory neurons as they matured.
Data indicate that prospero-related homeobox 1 (Prox1) has a role in regulating energy homeostasis in hepatocytes.
These results are the first demonstration that Prox1 (show C16orf35 Antibodies) activity protects pancreatic cells from acute tissue damage and early neoplastic transformation. Additional data in our study indicate that this novel role of Prox1 (show C16orf35 Antibodies) involves suppression of pathways associated with inflammatory responses and cell invasiveness.
the data show that Prox1 (show C16orf35 Antibodies) regulates proliferation and differentiation of the oligodendrocyte cell lineage, and is a relevant component of the endogenous regenerative response to Central nervous system injury.
Prox1 (show C16orf35 Antibodies) upregulation reduces proliferation, impairs maturation, and enables apoptosis in postnatal beta-cells. Prox1 (show C16orf35 Antibodies) overexpression causes MafA (show MAFA Antibodies) deficiency in beta-cells.
The PROX1 (show C16orf35 Antibodies)-mediated repression is weakened or lost, thereby facilitating the induction of Reverse cholesterol transport genes and diminishing the progression of atherosclerosis
using a transgenic reporter line, we show that prox1a is initially expressed in different endothelial compartments, becoming restricted to lymphatic endothelial cells only at later stages
Functional analysis using antisense morpholinos indicates that prox1 activity is crucial for the hair cells to differentiate properly and acquire functionality, while having no role in development of other cell types in neuromasts.
Prox1 functions as a tissue-specific coregulator of Ff1b
Our findings indicate that prox1 activity is crucial for the proper development of the otp1 (show OTOP1 Antibodies)-positive hypothalamic neuronal precursors to their terminal CA phenotype
The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants.
prospero homeobox 1
, prospero homeobox protein 1-like
, Prox 1
, prospero-related homeobox 1
, homeobox prospero-like protein PROX1
, prospero homeobox protein 1
, prospero-related homeobox gene 1