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PROX1 antibody (Center)

PROX1 Reactivity: Human, Mouse WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN357418
  • Target See all PROX1 Antibodies
    PROX1 (Prospero Homeobox 1 (PROX1))
    Binding Specificity
    • 16
    • 14
    • 12
    • 9
    • 9
    • 8
    • 8
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Center
    Reactivity
    • 102
    • 47
    • 26
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 94
    • 8
    Rabbit
    Clonality
    • 92
    • 10
    Polyclonal
    Conjugate
    • 47
    • 10
    • 10
    • 9
    • 8
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PROX1 antibody is un-conjugated
    Application
    • 92
    • 58
    • 42
    • 28
    • 13
    • 10
    • 10
    • 3
    • 2
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects PROX1 at Center.
    Purification
    Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. Then the antibody is purified by peptide affinity purification.
    Immunogen
    KLH conjugated synthetic peptide selected from the Center region of human PROX1
    Isotype
    Ig Fraction
    Top Product
    Discover our top product PROX1 Primary Antibody
  • Application Notes
    ELISA: 1/1,000. Western blot: 1/50 - 1/100. Immunohistochemistry: 1/10 - 1/50.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
  • Park, Cho, Park, Kim, Park, Myung, Lee, Kweon, Joo: "Prospero homeobox 1 mediates the progression of gastric cancer by inducing tumor cell proliferation and lymphangiogenesis." in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, Vol. 20, Issue 1, pp. 104-115, (2017) (PubMed).

    Park, Myung, Park, Kim, Oak, Myung, Cho, Lee, Kweon, Kim, Joo: "Impact of prospero homeobox-1 on tumor cell behavior and prognosis in colorectal cancer." in: American journal of cancer research, Vol. 5, Issue 11, pp. 3286-300, (2016) (PubMed).

  • Target
    PROX1 (Prospero Homeobox 1 (PROX1))
    Alternative Name
    PROX-1 (PROX1 Products)
    Synonyms
    xprox1 antibody, prospero antibody, PROX1 antibody, LOC100232600 antibody, A230003G05Rik antibody, prox1 antibody, zgc:111888 antibody, prospero homeobox 1 antibody, prospero homeobox 1 L homeolog antibody, prospero homeobox 1a antibody, PROX1 antibody, prox1.L antibody, prox1 antibody, Prox1 antibody, prox1a antibody
    Background
    The expression pattern of Prox1 suggests that it has a role in a variety of embryonic tissues, including lens. Prox mRNA is present in many different human tissues with lens demonstrating the highest level. Homozygous Prox1-null mice die at midgestation from multiple developmental defects, and a targeted effect on lens development has been reported. Prox1 inactivation caused abnormal cellular proliferation, downregulated expression of the cell cycle inhibitors Cdkn1b and Cdkn1c, misexpression of E-cadherin, and excessive apoptosis. Consequently, mutant lens cells failed to polarize and elongate properly, resulting in a hollow lens. Prox1 is expressed in a subpopulation of endothelial cells that by budding and sprouting give rise to the lymphatic system. Prox1 appears to be a specific and required regulator of the development of the lymphatic system. Prox1 also has been documented to be required for hepatocyte migration in the mouse. Loss of Prox1 results in a smaller liver with a reduced population of clustered hepatocytes. The homeodomain protein Prox1 regulates the egress of progenitor cells from the cell cycle in the embryonic mouse retina. Cells lacking Prox1 are less likely to stop dividing, and ectopic expression of Prox1 forces progenitor cells to exit the cell cycle. Prox1 acts as a key participant in progenitor-cell proliferation and cell-fate determination in the vertebrate retina.Synonyms: Homeobox prospero-like protein PROX1, PROX1, Prospero homeobox protein 1
    Molecular Weight
    83162 Da
    Gene ID
    5629, 9606
    UniProt
    Q92786
    Pathways
    Stem Cell Maintenance, Regulation of Muscle Cell Differentiation
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