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anti-Human NMDAR2A Antibodies:
anti-Rat (Rattus) NMDAR2A Antibodies:
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Mammalian Monoclonal NMDAR2A Primary Antibody for ISt, IHC - ABIN1304680
DOrsi, Kilbride, Chen, Perez Alvarez, Bonner, Pfeiffer, Plesnila, Engel, Henshall, Düssmann, Prehn: Bax regulates neuronal Ca2+ homeostasis. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2015
Show all 5 Pubmed References
Human Polyclonal NMDAR2A Primary Antibody for IF (p), IHC (p) - ABIN747353
Zhao, Li, Wei, Savage, Zhou, Ma: Ketamine administered to pregnant rats in the second trimester causes long-lasting behavioral disorders in offspring. in Neurobiology of disease 2014
Show all 3 Pubmed References
Rat (Rattus) Polyclonal NMDAR2A Primary Antibody for WB - ABIN361393
Brady, Diaz, Iuso, Everett, Valenzuela, Caldwell: Moderate prenatal alcohol exposure reduces plasticity and alters NMDA receptor subunit composition in the dentate gyrus. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2013
Rat (Rattus) NMDAR2A Primary Antibody for ELISA, WB - ABIN1742591
Wang, Liu, Fu, Wang, Lu: Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors. in Nature neuroscience 2003
Lifetime mood disorder emerged as a more significant factor for suicidal ideation in systemic lupus erythematosus compared with NR2A gene polymorphism main and interaction effects.
The results of this study GRIN2A mutation is a genetic cause in less than 11% patients with Landau-Kleffner syndrome or atypical benign partial epilepsy.
Mutations P79R (show ABCD4 Antibodies), C231Y, G483R and M705V caused a significant reduction in glutamate (show GRIN1 Antibodies) and glycine agonist potency, whilst D731N was non-responsive. These mutants, along with E714K, also showed significantly decreased total protein levels and trafficking to the cell surface, whilst C436R was not trafficked at all.
This review showed that GRIN2A associate with Obsessive-compulsive disorder.
This study demonstrates that GRIN2A mutations in melanoma cause heterogenous effects but some may be oncogenic.
data indicate that children with epilepsy due to pathogenic GRIN2A mutations present with different clinical phenotypes and a spectrum of seizure types in the context of a pharmacoresistant epilepsy.
2-methoxyestradiol impacts on glycine/serine-mediated metabolic reprogramming in osteosarcoma cells by its interaction with GRIN1 (show GRIN1 Antibodies)/GluN2A receptors.
a de novo missense mutation in the GRIN2A gene in a patient with childhood focal epilepsy and acquired epileptic aphasia. The mutant decreases NMDAR (show GRIN1 Antibodies) activation suggesting NMDAR (show GRIN1 Antibodies) hypofunction may contribute to the epilepsy pathogenesis.
genetic association studies in population in China: Data suggest that one SNP in GRIN2A (rs2650429; but not rs6497540 or rs9302415) is associated with lead-induced neurotoxicity; in this case-control study, cases were lead-exposed workers from battery plants. Lead-exposed individuals have lower serum GRIN2A levels compared with controls; lead decreases GRIN2A expression levels in HEK293 cell.
Two adjacent phenylalanines in the NMDA receptor GluN2A subunit M3 domain interactively regulate alcohol sensitivity and ion channel gating.
Study indicates that a lack of GluN2A-containing NMDARs alters the fine control of redox status, leading to a delayed maturation of perineuronal nets, and conferring vulnerability for long-term oxidative stress, microglial activation, and parvalbumin (show PVALB Antibodies) interneurons network dysfunction.
this study reveals an unexpected role of glycine in eliciting a non-ionotropic activity of GluN2ARs to confer neuroprotection via Akt (show AKT1 Antibodies) activation.
Results show the coupling of GluN subunit 2A with interacting proteins, particularly postsynaptic density-95 (PSD95 (show DLGAP2 Antibodies)) is modulated by CIN (show PDXP Antibodies).
activity-based anorexia resilience, quantified as suppression of hyperactivity, correlated strongly with reserve pools of NR2A-NMDA receptors in spine cytoplasm
Sepsis selectively decreased the protein and mRNA levels of GluN2A, GluN2B (show GRIN2B Antibodies) and GluN1 (show GRIN1 Antibodies) but not the levels of synaptophysin (show SYP Antibodies) or the neuronal number in the hippocampus of septic mice.
Drebrin A (show DBN1 Antibodies) can be found co-clustering with NR2B (show GRIN2B Antibodies)-containing NMDARs at the plasma membrane, while NR2A-containing NMDARs co-traffic into the spine cytoplasm but do not co-cluster at the plasma membrane.
This study demonstrated that Increasing the GluN2A/GluN2B (show GRIN2B Antibodies) Ratio in Neurons of the Mouse Basal and Lateral Amygdala Inhibits the Modification of an Existing Fear Memory Trace.
Grin2aPKC mice exhibit reduced anxiety in the open field test, light dark emergence test, and elevated plus maze. Overall, these results suggest that at least one of those PKC (show PKC Antibodies)-mediated phosphorylation sites regulates NMDAR (show GRIN1 Antibodies)-mediated signaling that modulates anxiety.
These data suggest that chronic early postnatal SSS influences spatial learning and memory ability, levels of hippocampal NR2B (show GRIN2B Antibodies), and NR2A/NR2B (show GRIN2B Antibodies) ratios in adult males.
Rph3A (show RPH3A Antibodies) interacts with GluN2A and PSD-95 (show DLG4 Antibodies) forming a complex that regulates NMDARs stabilization at postsynaptic membranes.
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
N-methyl-D-aspartate receptor subunit NR2A
, glutamate receptor, ionotropic, N-methyl D-aspartate 2A
, glutamate [NMDA] receptor subunit epsilon-1-like
, N-methyl D-aspartate receptor subtype 2A
, N-methyl-D-aspartate receptor channel, subunit epsilon-1
, N-methyl-D-aspartate receptor subunit 2A
, NMDA receptor subtype 2A
, glutamate [NMDA] receptor subunit epsilon-1
, glutamate receptor ionotropic, NMDA 2A
, glutamate [NMDA] receptor subunit epsilon 1
, glutamate receptor, ionotropic, N-methyl-D-aspartate subunit 2A