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Rat (Rattus) SNCA Protein expressed in Rabbit - ABIN1742284
Jüttner, Moré, Das, Babich, Meier, Henning, Erdmann, Mu Ller, Otto, Grantyn, Rathjen: Impaired synapse function during postnatal development in the absence of CALEB, an EGF-like protein processed by neuronal activity. in Neuron 2005
Human SNCA Protein expressed in Escherichia coli (E. coli) - ABIN2005039
Lee, Choi, Lee: Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form. in The Journal of biological chemistry 2002
Show all 2 Pubmed References
study examined the spatial and temporal expression patterns of three synuclein genes (snca, sncbb, sncg) during embryogenesis
A53T SNCA missense mutation caused impaired light entrainment of the circadian system in mice.
Induction of the Immunoproteasome Subunit Lmp7 Links Proteostasis and Immunity in alpha-Synuclein Aggregation Disorders
In this study, we assessed the spread of pathology following a localized induction of alphaS inclusions in the lumbar spinal cord following a unilateral injection in the sciatic nerve. Using this paradigm, we demonstrated the ability for alphaS inclusion spread and/or induction along neuroanatomical tra (show PRNP Proteins)cts within the CNS of two alphaS-overexpressing mouse models.
These results indicated that integrin CD11b (show ITGAM Proteins) mediates alpha-synuclein-induced NOX2 (show CYBB Proteins) activation through a RhoA (show RHOA Proteins)-dependent pathway.
High SNCA expression is associated with Parkinson's disease.
Snca regulates bone network homeostasis and ovariectomy-induced bone loss
These findings provide evidence for a novel mechanism underlying the protective effects of PINK1 (show PINK1 Proteins) against alpha-syn-induced neurodegeneration and highlight a novel therapeutic target for Parkinson's disease treatment.
study demonstrates that PLK-2 activity can rapidly change cellular alpha-synuclein levels in cell models and in mice brains, but this process does not require phosphorylation of S129. Instead, it operates via regulation of alpha-synuclein mRNA transcription in an open reading frame-dependent manner
the presented data link the Parkinson's disease-associated gene alpha-synuclein to the neuronal cell fate determinant TRIM32 (show TRIM32 Proteins).
alpha-synuclein levels can be reduced in neurons without impairing (or improving) mitochondrial bioenergetics or distribution
These results suggest that alpha-syn increases FoxO3a (show FOXO3 Proteins) expression as a result of its intrinsic ferrireductase activity. The results also suggest that FoxO3a (show FOXO3 Proteins) plays a pivotal role in the toxicity of both Fe(II) and toxic alpha-syn species to neuronal cells
dysregulation of the extended alpha-SYN 3'UTR might contribute to the pathogenesis of Parkinson's disease.
PD-1 (show PDCD1 Proteins) knockout combined with hTERT transduction could prolong the lifespan and enhance antitumor efficacy of CIK cells against hepatocellular carcinoma cell line.
We find evidence that the high-frequency peak in the amide-I spectrum of alpha-synuclein (alphaS)fibrils involves a normal mode that differs fundamentally from the canonical high-frequency antiparallel beta-sheet mode. The high sensitivity of the fibril structure to the ionic strength might form the basis of differences in alphaS-related pathologies.
Data shed light on ageing- and physical exercise-induced changes on the SNCA methylation status and protein levels of alpha-synuclein.
Single-nucleotide polymorphism rs356219 in the alpha-synuclein (SNCA) gene has been shown to significantly contribute to an earlier age at onset of Parkinson's disease (PD), and regulates SNCA expression in PD brain regions, blood, and plasma.
alterations in the plasma alpha-synuclein and beta-synuclein levels might be implicated in the association between synaptic abnormalities and autism spectrum disorder pathogenesis.
Intracerebral inoculation of purified Lewy bodies-type alpha-synuclein aggregates from postmortem Parkinson's disease stellate ganglia into mice did not trigger long-term nigrostriatal neurodegeneration nor alpha-synuclein pathology. Results argue against a putative pathogenic capacity of peripheral alpha-synuclein aggregates to promote alpha-synuclein pathology in brain, propagate between neuronal networks or induce n...
Double mutant mice with loss of Atp13a2 (show ATP13A2 Proteins) function combined with overexpression of human wildtype aSyn showed an earlier onset and accelerated alterations in sensorimotor function that were age, sex and test-dependent. Female 13a2-aSyn mice showed early and progressive dysfunction on the beam and in locomotor activity. In males, 13a2-aSyn mice showed more severe impairments in spontaneous activity and adhesive removal.
We revealed a relatively decreased efficiency for human alphaS fibrils containing the E46K mutation to induce disease via this injection paradigm, supportive of recent studies demonstrating a diminished ability of this mutant alphaS to undergo aggregate induction. These results further demonstrate prion (show PRNP Proteins)-like properties for alphaS by the ability for a progression and spread of alphaS inclusion pathology along neuroanato...
analysis of membrane curvature sensing by amphipathic helices using alpha-synuclein and annexin B12 (show TNFAIP1 Proteins) [ANXB12]
Immunocytochemistry shows alpha synuclein localized to the Golgi apparatus and vesicles of bovine adrenal medullary chromaffin cells, consistent with its putative role in vesicular function within synapses.
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.
, alpha SYN
, non-A beta component of AD amyloid
, non-A4 component of amyloid
, non A-beta component of AD amyloid
, synuclein alpha-140
, alpha synuclein