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results suggest that CD4 (show CD4 Proteins) CD8 double knockout (DN)T cells can develop efficiently in vivo and chronic exposure to bacterial superantigens may precipitate a lupus-like autoimmune disease through activation of DNT (show NT5C Proteins) cells
The generation of cancer-specific CD8(+) CD69 (show CD69 Proteins)(+)-expressing lymphocytes that inhibit colon cancer growth has been described.
TCF-1-deficient CD4+ CD8+ double positive thymocytes fail to undergo TCR alpha Valpha14-Jalpha18 rearrangement and produce significantly fewer Natural killer T cells.
Batf3 (show BATF3 Proteins) deficiency is not critical for the generation of CD8alpha dendritic cells
Lck (show LCK Proteins)-CD8 interaction is required for initial CD8 recruitment.
Brd1 (show BRD1 Proteins)-mediated Hbo1 (show MYST2 Proteins) activity is crucial for efficient activation of CD8 expression via acetylation at H3K14, which serves as an epigenetic mark that promotes the recruitment of transcription machinery to the CD8 enhancers.
Ly49E is expressed on a high proportion of CD8alphaalpha-positive intestinal intraepithelial lymphocytes.
Comparing the sequences of mouse, human, rat and dog Cd8a and Cd8b1 gene loci identified 10 evolutionarily conserved regions (ECR). 6 ECRs overlapped with previously identified Cd8 enhancers. ECR-4 recruits transcription factors to the Cd8ab gene complex.
Data indicate that orphan G-protein-coupled receptor GPR18 is required for the normal homeostasis of CD8alphaalpha gammadeltaT and alphabetaT and CD8alphabeta intestinal intraepithelial lymphocyte compartment.
CD8alpha DCs, rather than CD8 T cells, are responsible for enhanced viral latency and recurrences.
Studied lymphocyte phenotype in resected lymph nodes of patients with lung cancer by analyzing levels of Foxp3 (show FOXP3 Proteins) and CD8 by immunohistochemical staining.
This study compares the differences of PD-L1 (show CD274 Proteins) expression and CD8+ tumor-infiltrating lymphocyte density, two major response biomarkers of PD-1 (show PDCD1 Proteins)/PD-L1 (show CD274 Proteins) blockade, between paired primary and brain metastatic lesions in advanced non-small cell lung cancer (NSCLC). For NSCLC brain metastases patients, CD8+ tumor-infiltrating lymphocyte density showed a spatial and temporal heterogeneity.
Long-term lung function decline in asthma is associated with elevation of bronchial CD8 and CD4 at baseline, and CD8, CD3 and granzyme B at follow-up
Endometrioid endometrial carcinomas are capable of down-regulating CD8 expression by cytotoxic T lymphocytes.
The PD-1 (show PDCD1 Proteins)/CD8 ratio may, therefore, be a useful prognostic marker for stage II/III CRC (show CALR Proteins). What is important for predicting the prognosis may be the PD-1 (show PDCD1 Proteins)/CD8 ratio rather than the absolute number of PD-1 (show PDCD1 Proteins)(+) tumor-infiltrating lymphocytes .
We also observed a significant association between forkhead box protein 3 (show HSPB3 Proteins) ( p = 0.001) and the Neo-Bioscore, while only a marginal difference was observed with CD8+ expression ( p = 0.074). This study demonstrated that forkhead box protein 3 (show HSPB3 Proteins) expression has value as the only independent marker that predicts a good response to neoadjuvant chemotherapy and that it is related with a good prognosis according to the Neo-Biosc
Human mesenchymal stromal cells enhance the immunomodulatory function of CD8(+)CD28 (show CD28 Proteins)(-) regulatory T cells.
In localized colorectal cancer carriers, mRNA-based CD3Z (show CD247 Proteins)/CD8 profiling of tumor immune response may have stage, site and tissue-specific prognostic significance, along with ESR1 (show ESR1 Proteins) expression.
Dendritic cells accumulate in the bone marrow of multiple myeloma patients and protect tumor plasma cells from CD8+ T-cell killing.
Patients with the presence of CD8- and CD45RO-positive T cells in bone marrow demonstrated better survival of gastric cancer patients than those with the absence of these cells in bone marrow.
Findings indicate associations of differentiation 8 alpha (CD8A) variants with T lymphocyte subpopulations and suggest applications in porcine breeding programs.
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene.
, CD8a molecule
, T-cell surface glycoprotein CD8 alpha chain
, CD8 antigen, alpha polypeptide
, T-cell surface glycoprotein CD8 alpha chain-like
, Lyt-2.1 lymphocyte differentiation antigen (AA at 100)
, T-cell surface glycoprotein Lyt-2
, CD8 antigen, alpha polypeptide (p32)
, Leu2 T-lymphocyte antigen
, OKT8 T-cell antigen
, T cell co-receptor
, T-cell antigen Leu2
, T-lymphocyte differentiation antigen T8/Leu-2
, T8 T-cell antigen
, CD8 antigen 32 kDa chain
, CD8 antigen alpha-chain
, CD8 antigen, alpha chain
, CD8 antigen, alpha-chain
, OX-8 membrane antigen
, CD8 antigen alpha polypeptide
, CD8 alpha chain
, T-cell surface molecule
, CD8 alpha molecule