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anti-Human HLA-DRB3 Antibodies:
anti-Rat (Rattus) HLA-DRB3 Antibodies:
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In contrast to HLA-DRB4*01:01P, the inheritance of HLA-DRB3*01:01 is strongly associated with the propensity for mounting a humoral immune response against fetal HPA-1a antigen.
our findings provide clear evidence that the HLA-DRB1*15:01 and HLA-DRB3*02:02 alleles independently and strongly associate with phospholipase A2 receptor related idiopathic membranous nephropathy in the Chinese population
The first time that the haplotypes A33-DR3 and A33-DR9 were found with an enhanced predisposition to type 1 diabetes in Han Chinese.
HLA-DRB3 affects type 1 diabetes risk and islet autoantibodies.
this mouse model unravels a critical role for HLA-DR3 in generating an autoimmune response to SmD and lupus nephritis in the NZM2328 background.
Haplotyping was done on 91 Southern Europe celiac patients. HLA-DR3-DQ2 without HLA-DR7-DQ2 was present in 62.6%, HLA-DR7-DQ2 without HLA-DR3-DQ2 was present in 16.5% and HLA-DR4-DQ8 without HLA-DQ2 was present in 3.3%.
Children with the HLA haplotype DR3-DQ2, especially homozygotes, were found to be at high risk for celiac disease autoimmunity and celiac disease early in childhood.
The unusual DRB1*08:01 haplotype carrying DRB3*02:02 has been confirmed in a Dutch family.
HLA-DRB3*02:02 on the DRB1*03:01 haplotype can contribute to type 1 diabetes risk.
Prospective evaluation of matching for HLA-DRB3/4/5, -DQ, and -DP loci is warranted to reduce posttransplant risks in donor-recipient pairs matched for 7/8 HEL.
Three sets of HLA-DR3-positive haplotypes are designed that provide maximum risk of type 1 diabetes development in Indians and suggest a common Caucasian ancestor from which multiple haplotypes evolve independently.
Heterozygosity of HLA-DRB3*01:01 and HLA-DRB4*01:01 as a potential predictor of fetal neonatal alloimmune thrombocytopenia.
There was a strong sporadic inclusion body myositis association with the carriage of the DRB3*01:01 allele which was accounted for by its linkage disequilibrium with DRB1*03:01.
TNF associations with type 1 diabetes are caused by their linkage disequilibrium with specific HLA-DR3-DQ2 haplotypes in the Indian population.
In addition to confirming one of the top findings in the meta-analysis, TRIM26, RNF5 and HLA-DRB3 have been identified as potential candidate genes for schizophrenia.
There are no significant differences in the HLA-DRB3/B4/B5 homozygosity and heterozygosity rates between Korean males and females in both newborns and adults.
All patients with sporadic inclusion body myositis carried the HLA-DRB1*0301 allele, or its equivalent HLA-DR3 serological specificity
Patients with Wolfram syndrome have a different profile of the HLA antigens with the presence of DR2, DQw1 and DRB3/4 allele and are negative for diabetes-related autoantibodies
CatG cleaves human leukocyte antigen (HLA)-DR in vitro. Cleavage occurred on the loop between fx1 and fx2 of the membrane-proximal beta2 domain. In vivo, however, the CatG cleavage site is sterically inaccessible or masked by associated molecules.
IA2 positivity was associated with HLA-DR4/X and HLA-DR3/4 positivity, and hypothyroidism was linked to HLA-DR4/4.
In this study, we showed that BoLA-DRB3 was a good marker for determining which cow spread Bovine leukemia virus, and we found not only one resistant allele (BoLA-DRB3*009:02), but also two other disease-resistant alleles and two disease-susceptible alleles.
It was concluded that the ability of cattle carrying resistance-associated marker BoLA DRB3*0902 to control bovine leukemia virus and to progress towards a low proviral load phenotype was not altered by M. bovis co-infection.
The association of the bovine MHC class II BoLA-DRB3.2 alleles with Bovine leukemia virus infection profiles was examined.
This study showed that the effect of the genotype at the BoLA-DRB3 locus does not explain variation in somatic cell count and milk yield at a degree expected of a genetic marker.
Forty-six BoLA-DRB3 alleles have been identified in Chilean cattle.
polymorphisms associated with resistance and susceptibility to the bovine leukemia Virus progression
The relationship between BoLA-DRB3 alleles and tick-borne disease resistance in Zebu and Holstein cross dairy cattle is reported.
The results of this study demonstrated that the BoLA-DRB3.2 is a highly polymorphic locus, with significant breed-specific genetic diversities being present amongst the three studied cattle breeds.
BoLA-DRB3.2 may be a candidate gene for lameness susceptibility in Chinese Holstein cows.
Various BoLA-DRB3 gene polymorphisms were associated with either foot-and-mouth disease resistance or susceptibility in Wanbei cattle.
The findings indicate potentially important mutations in the protein-binding site of DRB3, which may be crucial to the activation of an appropriate immune response against paratuberculosis.
Their DRB3 alleles were identified using PCR-sequence-based typing (PCR-SBT). The differences in DRB3 allelic frequencies between healthy cows and cows with various degrees of mastitis were re-investigated.
A total of five alleles including four newly identified ones, named BoLA-DRB3*R-03-U2, BoLA-DRB3*R-06-U2, BoLA-DRB3*R-07-U and BoLA-DRB3*R-12-U for the BoLA-DRB3 URR were found.
Polymorphism of the BoLA-DRB3 gene in the Mongolian, Kalmyk, and Yakut cattle breeds
Possible causes and consequences of the spread of individual allelic variants of the BoLA-DRB3 locus in groups of Holstein and Ayrshire cattle
identified 14 different DRB3 and 10 different DQA1 alleles in this population
The present study failed to find any association between milk yield and tested alleles in DRB3.2.
Different spectra of BoLA-DRB3 alleles mediating susceptibility and resistance to leukemia were detected
A rapid, high-resolution sequence-based typing system for BoLA-DRB3 exon 2 was developed.
Analysis of BoLA-DRB3 diversity in 201 animals identified significant associations with Theileria parva vaccine success (DRB3*2703; P = 0.027) and vaccine failure (DRB3*1501; P = 0.013).
HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
, HLA class II histocompatibility antigen, DR beta 3 chain
, HLA class II histocompatibility antigen, DRB1-7 beta chain
, MHC class II HLA-DR beta 3 chain
, MHC class II antigen DR beta 3 chain
, MHC class II antigen DRB3
, human leucocyte antigen DRB3
, DR beta-chain antigen binding domain
, DR-beta chain MHC class II
, MHC class II DR beta chain
, MHC class II DRB3
, MHC class II antigen BoLA-DRB3
, MHC class II antigen beta chain
, MHC class II leukocyte antigen BoLA-DRB3
, MHC(BoLA) class II DR-beta chain
, histocompatibility complex, class II, DR beta 3
, leukocyte antigen DRB3
, major histocompatibility complex class II DR-beta chain
, major histocompatibility complex, class II, DR beta 3
, major histocompatibility complex, class II, DRB3