anti-HLA-DRB3 Antibodies

Protein Summary

HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.

Alternative names and synonyms associated with HLA-DRB3

• major histocompatibility complex, class II, DR beta 3 (HLA-DRB3) antibody
• major histocompatibility complex, class II, DRB3 (BOLA-DRB3) antibody

• BLA-DRB3 antibody
• Bota-DRB01 antibody
• Bota-DRB02 antibody
• Bota-DRB04 antibody
• Bota-DRB07 antibody
• Show all synonym aliases
• Bota-DRB21 antibody
• Bota-DRB22 antibody
• HLA-DR3B antibody
• LA-DRB antibody

Protein level used designations for HLA-DRB3

DR7 , HLA class II histocompatibility antigen, DR beta 3 chain , HLA class II histocompatibility antigen, DRB1-7 beta chain , MHC class II HLA-DR beta 3 chain , MHC class II antigen DR beta 3 chain , MHC class II antigen DRB3 , human leucocyte antigen DRB3 , BoLA-DRB3.2 , DR beta-chain antigen binding domain , DR-beta chain MHC class II , MHC class II DR beta chain , MHC class II DRB3 , MHC class II antigen BoLA-DRB3 , MHC class II antigen beta chain , MHC class II leukocyte antigen BoLA-DRB3 , MHC(BoLA) class II DR-beta chain , histocompatibility complex, class II, DR beta 3 , leukocyte antigen DRB3 , major histocompatibility complex class II DR-beta chain , major histocompatibility complex, class II, DR beta 3 , major histocompatibility complex, class II, DRB3