Browse our anti-LCP2 (LCP2) Antibodies

Mouse (Murine) Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) interaction partners

1. Biochemical analyses revealed that mutant T cells were hypersensitive to TCR stimulation. Indeed, phosphorylation of several signaling proteins, including SLP76 itself, phospholipase Cgamma1 and the protein kinases AKT and ERK1/2, was increased

2. slp-76 contributes to the regulation of the tissue distribution, PLZF (show ZBTB16 Antibodies), and cytokine expression of iNKT cells via ADAP (show APP Antibodies)-dependent and -independent mechanisms.

3. findings identify ACK1 (show TNK2 Antibodies) as a novel SLP-76-associated protein-tyrosine kinase (show YES1 Antibodies) that modulates early activation events in T cells.

4. immune cell adaptor SLP-76 binds directly to SUMO-RanGAP1 (show RANGAP1 Antibodies) of cytoplasmic fibrils of the nuclear pore complex, and this interaction is needed for optimal NFATc1 (show NFATC1 Antibodies) and NF-kappaB (show NFKB1 Antibodies) p65 (show NFkBP65 Antibodies) nuclear entry in T cells

5. these studies establish Slp-76 as a critical determinant of NK-cell development and NK cell mediated elimination of missing-self target cells in mice

6. Data show that a splice variant of SLP-76 signal transducing adaptor protein (SLP-76 or Lcp2) reduced the amount of SLP-76 protein by ~90%, disrupting immunogenic and tolerogenic pathways to different degrees.

7. this analysis identified 65 proteins not associated before with the Zap70 (show ZAP70 Antibodies)-Lat (show LAT Antibodies)-SLP-76 network and thus should provide cues for future functional experiments.

8. A yopH mutant survived better in the absence of neutrophils, indicating that neutrophil inactivation by YopH by targeting PRAM-1 (show PRAM1 Antibodies)/SKAP-HOM (show SKAP2 Antibodies) and SLP-76/Vav (show VAV1 Antibodies)/PLCgamma2 (show PLCG2 Antibodies) signaling hubs may be critical for Yersinia survival.

9. analysis of a costimulatory mechanism by which CXCL12 (show CXCL12 Antibodies) and antigen converge at SLP-76 microcluster formation to enhance T cell responses

10. Findings indicate that SLP-76 is an essential signaling component for basophil activation downstream of both FcepsilonRI (show FCER1A Antibodies) and the IL-3 (show IL-3 Antibodies) receptor.

Human Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) interaction partners

1. a previously unappreciated role for PLC-gamma1 (show PLCG1 Antibodies) in the positive regulation of Zap-70 (show ZAP70 Antibodies) and T-cell receptor tyrosine phosphorylation. Conversely, PLC-gamma1 (show PLCG1 Antibodies) negatively regulated the phosphorylation of SLP-76-associated proteins, including previously established Lck (show LCK Antibodies) substrate phosphorylation sites within this complex.

2. These data are consistent with a model in which bivalent recruitment of a GADS (show GRAP2 Antibodies)/SLP-76 complex is required for costimulation by CD6 (show CD6 Antibodies).

3. LAT (show ORC3 Antibodies) and SLP-76 are randomly dispersed throughout the clusters that form upon T cell receptor engagement.

4. SLP76 is ectopically expressed in chronic lymphocytic leukemia cells where it plays a role in B-cell receptor signaling.

5. findings identify ACK1 (show TNK2 Antibodies) as a novel SLP-76-associated protein-tyrosine kinase (show EPHA8 Antibodies) that modulates early activation events in T cells.

6. Data strongly suggest that chemokine (show CCL1 Antibodies)-stimulated associations between Vav1 (show VAV1 Antibodies), SLP-76, and ADAP (show FYB Antibodies) facilitate Rac1 (show RAC1 Antibodies) activation and alpha4beta1-mediated adhesion, whereas Pyk2 (show PTK2B Antibodies) opposes this adhesion by limiting Rac1 (show RAC1 Antibodies) activation.

7. TSAD (show SH2D2A Antibodies) binds to and co-localizes with Nck (show NCK1 Antibodies). Expression of TSAD (show SH2D2A Antibodies) increases both Nck (show NCK1 Antibodies)-Lck (show LCK Antibodies) and Nck (show NCK1 Antibodies)-SLP-76 interaction in T cells.

8. immune cell adaptor SLP-76 binds directly to SUMO-RanGAP1 (show RANGAP1 Antibodies) of cytoplasmic fibrils of the nuclear pore complex, and this interaction is needed for optimal NFATc1 (show NFATC1 Antibodies) and NF-kappaB (show NFKB1 Antibodies) p65 (show GORASP1 Antibodies) nuclear entry in T cells

9. SLP-76 N-terminal tyrosine residues regulate a dynamic signaling equilibrium involving feedback of proximal T-cell receptor signaling

10. analysis of a costimulatory mechanism by which CXCL12 (show CXCL12 Antibodies) and antigen converge at SLP-76 microcluster formation to enhance T cell responses