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LCP2 Products

(Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2))

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SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function. [provided by RefSeq, Jul 2008].

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Featured LCP2 Categories

LCP2 Antibodies

High quality antibodies with extensive validation data.

LCP2 ELISA Kits

Reliable ELISA kits for a wide range of species.

LCP2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended LCP2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Application ICC, IHC, WB
Validations
  • (4)
Cat. No. ABIN1859636
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC, ELISA, WB
Validations
  • (1)
  • (2)
Cat. No. ABIN1532089
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, ICC, IF, IHC, WB
Validations
  • (3)
Cat. No. ABIN6262938
Quantity 100 μL
Datasheet Datasheet

Recommended LCP2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method
Validations
Cat. No. ABIN1141096
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1141097
Quantity 96 tests
Datasheet Datasheet

Recommended LCP2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3082784
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3122746
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1309248
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our LCP2 products

Tomomura, Hasegawa, Suda, Sakagami, Tomomura et al.: "Serum calcium-decreasing factor, caldecrin, inhibits receptor activator of NF-?B ligand (RANKL)-mediated Ca2+ signaling and actin ring formation in mature osteoclasts via suppression of Src signaling ..." in: The Journal of biological chemistry, Vol. 287, Issue 22, pp. 17963-74, (2012) (PubMed).

Lin, Liu, Moore, Elizer, Veach, Hawiger, Ruley: "Cutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 188, Issue 6, pp. 2493-7, (2012) (PubMed).

Brockmeyer, Paster, Pepper, Tan, Trudgian, McGowan, Fu, Gascoigne, Acuto, Salek: "T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component." in: The Journal of biological chemistry, Vol. 286, Issue 9, pp. 7535-47, (2011) (PubMed).

Lasserre, Cuche, Blecher-Gonen, Libman, Biquand, Danckaert, Yablonski, Alcover, Di Bartolo: "Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation." in: The Journal of cell biology, Vol. 195, Issue 5, pp. 839-53, (2011) (PubMed).

Beach, Gonen, Bogin, Reischl, Yablonski: "Dual role of SLP-76 in mediating T cell receptor-induced activation of phospholipase C-gamma1." in: The Journal of biological chemistry, Vol. 282, Issue 5, pp. 2937-46, (2007) (PubMed).

Bogin, Ainey, Beach, Yablonski: "SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 16, pp. 6638-43, (2007) (PubMed).

Di Bartolo, Montagne, Salek, Jungwirth, Carrette, Fourtane, Sol-Foulon, Michel, Schwartz, Lehmann, Acuto: "A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76." in: The Journal of experimental medicine, Vol. 204, Issue 3, pp. 681-91, (2007) (PubMed).

Koretzky, Abtahian, Silverman: "SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond." in: Nature reviews. Immunology, Vol. 6, Issue 1, pp. 67-78, (2006) (PubMed).

Wu, Koretzky: "The SLP-76 family of adapter proteins." in: Seminars in immunology, Vol. 16, Issue 6, pp. 379-93, (2004) (PubMed).

Janssen, Zhang: "Adaptor proteins in lymphocyte activation." in: Current opinion in immunology, Vol. 15, Issue 3, pp. 269-76, (2003) (PubMed).

Synonyms and alternative names related to LCP2

lymphocyte cytosolic protein 2 (Lcp2), lymphocyte cytosolic protein 2 (LCP2), AI323664, BB161688, SLP-76, SLP76, Slp76, twm

Protein level used designations for LCP2

  • SH2 domain-containing leukocyte protein of 76 kDa
  • SLP-76 tyrosine phosphoprotein
  • lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76kD)
  • 76 kDa tyrosine phosphoprotein
  • SH2 domain-containing leukocyte protein of 76kD
  • lymphocyte cytosolic protein 2
  • tyrosine phosphoprotein slp-76
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