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Human Monoclonal FEN1 Primary Antibody for ICC, IF - ABIN151083
Qiu, Li, Frank, Shen: Cell cycle-dependent and DNA damage-inducible nuclear localization of FEN-1 nuclease is consistent with its dual functions in DNA replication and repair. in The Journal of biological chemistry 2001
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Human Polyclonal FEN1 Primary Antibody for IP, WB - ABIN151786
Muftuoglu, Wong, Imam, Wilson, Bohr, Opresko: Telomere repeat binding factor 2 interacts with base excision repair proteins and stimulates DNA synthesis by DNA polymerase beta. in Cancer research 2006
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Human Polyclonal FEN1 Primary Antibody for ICC, IF - ABIN151787
Farina, Shin, Kim, Bermudez, Kelman, Seo, Hurwitz: Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1. in The Journal of biological chemistry 2008
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Human Polyclonal FEN1 Primary Antibody for WB - ABIN2801955
Murray, Tavassoli, al-Harithy, Sheldrick, Lehmann, Carr, Watts: Structural and functional conservation of the human homolog of the Schizosaccharomyces pombe rad2 gene, which is required for chromosome segregation and recovery from DNA damage. in Molecular and cellular biology 1994
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Human Polyclonal FEN1 Primary Antibody for IP, WB - ABIN151078
Wang, Brandt, Rossi, Lindsey-Boltz, Podust, Fanning, Sancar, Bambara: The human Rad9-Rad1-Hus1 checkpoint complex stimulates flap endonuclease 1. in Proceedings of the National Academy of Sciences of the United States of America 2004
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Data show that shade avoidance 6 (SAV6; At5g26680), encodes flap endonuclease-1 (FEN1), assures proper root development through maintenance of genome integrity.
These results reveal an important role of FEN1 phosphorylation to counteract oxygen-induced stress in the heart during the fetal-to-neonatal transition.
WDR4 (show WDR4 Antibodies) regulates FEN1's potential DNA cleavage threat near the site of replication.
The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN (show GEN1 Antibodies) activity, causing aneuploidy-associated cancers.
PARP1 (show PARP1 Antibodies) is required for FEN1 recruitment to DNA repair intermediates in base excision repair.
FFAA Fen1 mutation causes defective Pcna (show PCNA Antibodies) -coordinated Okazaki fragment maturation.
A point mutation in the base excision repair gene flap endonuclease 1 causes a functional deficiency in repairing base damage, such that individuals carrying the mutation or similar mutations are predisposed to chemical-induced cancer development.
FEN1 localization within the mitochondrial compartment of mouse brain tissue
Distinct roles for two Mg2 (show MCOLN1 Antibodies)+ binding sites in the regulation of FEN-1 nuclease (show DCLRE1C Antibodies) activities include enhancement of DNA substrate binding ability and modulation of conformational changes.
FEN1 has roles in DNA repair, as well as in DNA replication
Fen1 is induced independently in mouse embryonic fibroblasts by ultraviolet (UV-C)light
Results suggest that FEN1 polymorphisms may reduce the risk of breast cancer in Chinese women.
FEN1 is essential for prolifera- tion and cisplatin resistance of lung cancer cells.
Our results suggest that functional polymorphism FEN1 rs174538 G>A might affect personal susceptibility to esophageal squamous cell carcinoma . This result provides a solid theoretical foundation for further clinical study using larger sample sizes.
FEN1 sculpts DNA with diffusion-limited kinetics to test DNA substrate. This DNA distortion mutually 'locks' protein and DNA conformation and enables substrate verification with extreme precision.
Notably, non-small cell lung cancer patients with FEN1-overexpressed cancers were prone to have poor differentiation and poor prognosis. Furthermore, knockdown of FEN1 resulted in G1/S or G2/M phase cell cycle arrest and suppressed in vitro cellular proliferation in NSCLC cancer cells.
Overexpression of human XPG (show ERCC5 Antibodies) and FEN1 increases genome instability in U2OS cells
Data indicate that human cancer-associated genetic alterations in the FEN1 gene can contribute substantially to cancer development.
WRN (show RECQL2 Antibodies) or the Bloom syndrome helicase (BLM (show BLM Antibodies)) stimulates DNA polymerase delta (show POLD1 Antibodies) progression across telomeric G-rich repeats, only WRN (show RECQL2 Antibodies) promotes sequential strand displacement synthesis and FEN1 cleavage.
The FEN1 rs174538 A allele is a protective biomarker for childhood ALL and this association is more significant in males and in patients at onset age of 3.5 years or older.
Data indicate that Flap endonuclease 1 (FEN1) single nucleotide polymorphisms and haplotypes are associated with gallbladder cancer risk.
The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.
flap endonuclease 1
, Flap structure-specific endonuclease 1
, flap structure-specific endonuclease 1
, DNase IV
, maturation factor 1
, maturation factor-1
, 5' nuclease xFEN1a
, flap endonuclease 1-A
, flap structure-specific endonuclease 1-A