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anti-Human RUVBL2 Antibodies:
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Human Polyclonal RUVBL2 Primary Antibody for ELISA, WB - ABIN544685
Wood, McMahon, Cole: An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc. in Molecular cell 2000
Show all 3 Pubmed References
Human Polyclonal RUVBL2 Primary Antibody for IF, WB - ABIN524254
Maslon, Hrstka, Vojtesek, Hupp: A divergent substrate-binding loop within the pro-oncogenic protein anterior gradient-2 forms a docking site for Reptin. in Journal of molecular biology 2010
Cow (Bovine) Polyclonal RUVBL2 Primary Antibody for IHC, WB - ABIN2779601
Bauer, Chauvet, Huber, Usseglio, Rothbächer, Aragnol, Kemler, Pradel: Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity. in The EMBO journal 2000
Show all 2 Pubmed References
Reptin directly interacted with histone deacetylase 1 (HDAC1) as the critical mechanism driving non-small cell lung cancer (NSCLC) tumour progression. Pharmacological disruption of the Reptin/HDAC1 complex resulted in a substantial decrease in NSCLC cell proliferation and induced significant sensitisation to cisplatin.
These results suggest a role of Reptin and Pontin in Salivary gland cancer tumor progression and/or patient survival.
The interaction between RUVBL1/RUVBL2 and the U5 small nuclear ribonucleoprotein is mostly mediated by the previously uncharacterized factor ZNHIT2.
Mep1A is overexpressed in most hepatocellular carcinomas and induces tumor cell migration and invasion. Mep1A expression is regulated by Reptin, and Mep1A mediates Reptin-induced migration.
Reptin silencing did not affect the tyrosine phosphorylation of the insulin receptor nor of IRS1, but it enhanced the tyrosine phosphorylation of the p85 subunit of PI3K.
Overall, POLG interactome mapping identifies novel proteins which support mitochondrial biogenesis and a potential novel mitochondrial isoform of Ruvbl2.
The authors report that HIV-1 exploits the host factor RuvB-like 2 (RVB2) to balance relative expression of Gag and Env for efficient production of infectious virions.
by means of molecular docking approaches we first modeled the structures of hetero-hexameric TIP49 ( TIP49a and TIP49b )complexes with short ds-DNA fragments (20 base pairs with different GC content) within the central channel of hexameric ring
Data suggest that overexpression of Reptin in hepatocellular carcinoma (HCC) could be a factor of resistance to treatment.
RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils.
results reveal a novel mechanism for the control of NF-kappaB pathway by cytoplasmic Reptin
The results suggests that a potential mechanism for the role of RuvBL1-RuvBL2 in maintaining genome integrity is through controlling the cellular abundance of Fanconi anaemia core complex.
Reptin and Pontin oligomerization and activity are modulated through histone H3 N-terminal tail interaction.
these findings suggest that YY1-RuvBL1-RuvBL2 complexes could contribute to functions beyond transcription, and we show that YY1 and the ATPase activity of RuvBL2 are required for RAD51 foci formation during homologous recombination.
The Reptin is unable to bind with membrane-associated APPL proteins.
Anti-RuvBL1/2 antibody is a novel systemic scleroderma-related autoantibody associated with a unique combination of clinical features, including myositis overlap and diffuse cutaneous involvement.
Data suggest that reptin may prove to be a valuable target for prevention and treatment of renal cell carcinoma.
Data indicate that the RVB1/2 chromatin-remodeling complex is required for efficient Pol II recruitment and initiation at IFN-alpha-stimulated genes (ISGs) promoters and is recruited through interaction with the STAT2 transactivation domain.
We demonstrate that leukemogenic activity of MLL-AF9 requires RUVBL2 (RuvB-like 2), an AAA+ ATPase family member that functions in a wide range of cellular processes, including chromatin remodeling and transcriptional regulation.
Two coexisting conformations, compact and stretched, are revealed by analysis of cryo-electron microscopy structures of the RuvBL1-RuvBL2 complex.
Ruvbl2 has a role in the differentiation of neuroectoderm during early embryogenesis.
accumulating E2f1 progressively recruits a Pontin/Reptin complex to open the chromatin conformation at E2f target genes and amplifies the E2f transcriptional response.
Reptin plays a key role in maintaining the pluripotency of embryonic stem cells and in establishing the pluripotency during reprogramming of somatic cells by regulation of Oct4-mediated gene regulation
Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression.
A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity.
Ectopic expression of RUVBL2 decreases the levels of ARF, whereas knockdown of RUVBL2 results in a marked increase in ARF levels. In addition, RUVBL2 down-regulates the levels of p53 in an ARF-dependent manner.
Reptin, a chromatin-remodeling factor, is methylated at lysine 67 in hypoxic conditions by the methyltransferase G9a.
RuvBl2, which encodes an ATP-dependent DNA helicase, is specifically detected in the spermatocytes and spermatids of the adult testis as well as in primordial germ cells.
RUVBL2 plays an important role in insulin-stimulated GLUT4 translocation through its interaction with AS160
the Reptin-Lrrc6/Seahorse complex is involved in dynein arm formation.
the reptin/pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway
xPontin and xReptin are essential genes regulating cell proliferation in early Xenopus embryogenesis through interaction with c-Myc
This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation.
48 kDa TATA box-binding protein-interacting protein
, 48 kDa TBP-interacting protein
, 51 kDa erythrocyte cytosolic protein
, INO80 complex subunit J
, RuvB (E coli homolog)-like 2
, TIP60-associated protein 54-beta
, erythrocyte cytosolic protein, 51-KD
, repressing pontin 52
, reptin52 protein
, ruvB-like 2
, RuvB-like protein 2
, RuvB-like 2
, RuvB-like 2 (E. coli)
, ruvB-like 2-like
, ruvb-like 2
, ruvB-like helicase 2