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anti-Human RUVBL2 Antibodies:
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Human Polyclonal RUVBL2 Primary Antibody for IF, WB - ABIN524254
Maslon, Hrstka, Vojtesek, Hupp: A divergent substrate-binding loop within the pro-oncogenic protein anterior gradient-2 forms a docking site for Reptin. in Journal of molecular biology 2010
Cow (Bovine) Polyclonal RUVBL2 Primary Antibody for IHC, WB - ABIN2779601
Bauer, Chauvet, Huber, Usseglio, Rothbächer, Aragnol, Kemler, Pradel: Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity. in The EMBO journal 2000
Show all 2 Pubmed References
The interaction between RUVBL1/RUVBL2 and the U5 small nuclear ribonucleoprotein is mostly mediated by the previously uncharacterized factor ZNHIT2.
Mep1A (show MEP1A Antibodies) is overexpressed in most hepatocellular carcinomas and induces tumor cell migration and invasion. Mep1A (show MEP1A Antibodies) expression is regulated by Reptin, and Mep1A (show MEP1A Antibodies) mediates Reptin-induced migration.
Reptin silencing did not affect the tyrosine phosphorylation of the insulin receptor (show INSR Antibodies) nor of IRS1 (show IRS1 Antibodies), but it enhanced the tyrosine phosphorylation of the p85 subunit of PI3K (show PIK3CA Antibodies).
Overall, POLG (show POLG Antibodies) interactome mapping identifies novel proteins which support mitochondrial biogenesis and a potential novel mitochondrial isoform of Ruvbl2.
The authors report that HIV-1 exploits the host factor RuvB-like 2 (RVB2) to balance relative expression of Gag and Env (show ERVW-1 Antibodies) for efficient production of infectious virions.
by means of molecular docking approaches we first modeled the structures of hetero-hexameric TIP49 ( TIP49a and TIP49b )complexes with short ds-DNA fragments (20 base pairs with different GC content) within the central channel of hexameric ring
Data suggest that overexpression of Reptin in hepatocellular carcinoma (HCC (show FAM126A Antibodies)) could be a factor of resistance to treatment.
RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils.
results reveal a novel mechanism for the control of NF-kappaB (show NFKB1 Antibodies) pathway by cytoplasmic Reptin
The results suggests that a potential mechanism for the role of RuvBL1-RuvBL2 in maintaining genome integrity is through controlling the cellular abundance of Fanconi anaemia core complex.
Ruvbl2 has a role in the differentiation of neuroectoderm during early embryogenesis.
accumulating E2f1 (show E2F1 Antibodies) progressively recruits a Pontin/Reptin complex to open the chromatin conformation at E2f (show E2F1 Antibodies) target genes and amplifies the E2f (show E2F1 Antibodies) transcriptional response.
Reptin plays a key role in maintaining the pluripotency of embryonic stem cells and in establishing the pluripotency during reprogramming of somatic cells by regulation of Oct4 (show POU5F1 Antibodies)-mediated gene regulation
Gata3 (show GATA3 Antibodies)/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c (show CDKN2C Antibodies) expression.
We demonstrate that leukemogenic activity of MLL (show MLL Antibodies)-AF9 (show MLLT3 Antibodies) requires RUVBL2 (RuvB-like 2), an AAA (show AAAS Antibodies)+ ATPase (show DNAH8 Antibodies) family member that functions in a wide range of cellular processes, including chromatin remodeling and transcriptional regulation.
A forward genetic screen reveals roles for Nfkbid (show NFKBID Antibodies), Zeb1 (show ZEB1 Antibodies), and Ruvbl2 in humoral immunity.
Ectopic expression of RUVBL2 decreases the levels of ARF, whereas knockdown of RUVBL2 results in a marked increase in ARF levels. In addition, RUVBL2 down-regulates the levels of p53 in an ARF-dependent manner.
Reptin, a chromatin-remodeling factor (show ASH1L Antibodies), is methylated at lysine 67 in hypoxic conditions by the methyltransferase G9a (show EHMT2 Antibodies).
RuvBl2, which encodes an ATP-dependent DNA helicase, is specifically detected in the spermatocytes and spermatids of the adult testis as well as in primordial germ cells.
RUVBL2 plays an important role in insulin (show INS Antibodies)-stimulated GLUT4 (show SLC2A4 Antibodies) translocation through its interaction with AS160 (show TBC1D4 Antibodies)
the Reptin-Lrrc6/Seahorse (show LRRC6 Antibodies) complex is involved in dynein arm formation.
the reptin/pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin (show CTNNB1 Antibodies) pathway
xPontin and xReptin are essential genes regulating cell proliferation in early Xenopus embryogenesis through interaction with c-Myc (show MYC Antibodies)
This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation.
48 kDa TATA box-binding protein-interacting protein
, 48 kDa TBP-interacting protein
, 51 kDa erythrocyte cytosolic protein
, INO80 complex subunit J
, RuvB (E coli homolog)-like 2
, TIP60-associated protein 54-beta
, erythrocyte cytosolic protein, 51-KD
, repressing pontin 52
, reptin52 protein
, ruvB-like 2
, RuvB-like protein 2
, RuvB-like 2
, RuvB-like 2 (E. coli)
, ruvB-like 2-like
, ruvb-like 2
, ruvB-like helicase 2