USP18 Proteins

(Ubiquitin Specific Peptidase 18 (USP18))

The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011].

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5 results

USP18 Protein (AA 1-372) (His tag)

custom-made USP18 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

AlphaFold protein structure predicition of Human Recombinant USP18 Protein, UniprotID Q9UMW8

3 images

Catalog No. ABIN7544988

Details

USP18 Protein (AA 18-268) (His-IF2DI Tag)

USP18 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % by SDS-PAGE gel analyses ELISA, WB

Western Blotting (WB) image for Ubiquitin Specific Peptidase 18 (USP18) (AA 18-268) protein (His-IF2DI Tag) (ABIN7125590)

1 image

Catalog No. ABIN7125590

Details

USP18 Protein (AA 273-372) (GST tag)

USP18 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP

Image no. 1 for Ubiquitin Specific Peptidase 18 (USP18) (AA 273-372) protein (GST tag) (ABIN1324763)

1 image

Catalog No. ABIN1324763

Details

USP18 Protein (AA 1-372) (GST tag)

USP18 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP

Image no. 1 for Ubiquitin Specific Peptidase 18 (USP18) (AA 1-372) protein (GST tag) (ABIN1324762)

1 image

Catalog No. ABIN1324762

Details

USP18 Protein (AA 1-372) (Strep Tag)

custom-made USP18 Origin: Human Host: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). ELISA, WB, SDS

Catalog No. ABIN3075216