Browse our anti-Sphingosine Kinase 2 (SPHK2) Antibodies

Fruit Fly (Drosophila melanogaster) Sphingosine Kinase 2 (SPHK2) interaction partners

1. Sk1 and Sk2 are not redundant in biological function and are essential for diverse physiological functions in Drosophila

Human Sphingosine Kinase 2 (SPHK2) interaction partners

1. The results of this study suggested that a shift in the subcellular localization of the sphingosine 1-phosphate generating SphK2 may compromise the well established pro-survival cytosolic sphingosine 1-phosphate by favoring the production of nuclear sphingosine 1-phosphate associated with adverse effects in AD pathogenesis.

2. S1P produced by SphK1 and SphK2 may have different functions in pancreatic cancer.

3. Thus, these findings demonstrate a tumor-suppressive function of DYNC1I1, and uncover new mechanistic insights into SK2 regulation which may have implications in targeting this enzyme as a therapeutic strategy in glioblastoma

4. High SPHK2 expression is associated with lung cancer.

5. SPHK2 may promote glioma growth by stimulating tumor-associated macrophages to polarize M2-type macrophages

6. SPHK2 is highly expressed in the kidney interstitium of patients with renal fibrosis and highly correlates with disease progression. SPHK2 phosphorylates Fyn to activate downstream STAT3 and AKT, thereby promoting extracellular matrix synthesis, kidney fibroblast activation, and renal fibrosis.

7. Colony formation and cell proliferation were suppressed by enhanced expression of miR-338-3p in LC cells. Moreover, miR-338-3p targeted sphingosine kinase 2 (SphK2). Silencing of SphK2 had an identical influence as overexpression of miR-338-3p in LC cells.

8. siRNA-mediated knockdown of Sphk2 but not SphK1 resulted in a reduction of cargo content in purified exosomes

9. In colorectal cancer cell lines, inhibition of miR-363-3p elevated SphK2 levels.

10. This review focuses on the recent advances in research on SphK2 regulation and its potential roles in diseases, highlighting SphK2 may be a novel therapeutic strategy for diseases--{REVIEW}

11. the study revealed that lncRNA DANCR might promote the proliferation of osteoarthritis chondrocytes and reduce apoptosis through the miR-577/SphK2 axis.

12. these data demonstrate that SK-2 exerts an antiproliferative and apoptosis-sensitizing effect in renal mesangial cells which suggests that selective inhibitors of SK-2 may promote proliferation and reduce apoptosis

13. Results form study in non-small-cell lung cancer cells showed that SphK2 plays a critical role in doxorubicin-induced resistance by regulating key anti-apoptotic gene, survivin.

14. findings indicate that miR-577 is a potential tumor suppressor in Papillary Thyroid Cancer by targeting SphK2, and may be a potential therapeutic target in PTC.

15. These results provide new insights into the biological functions of Sphk2 and the molecular mechanisms that underlie the Sphk2-mediated resistance to retinoid therapy.

16. this study shows that SK2 can have a direct role in promoting oncogenesis

17. Data show that inhibition of sphingosine kinase-2 by ABC294640 is synergistically cytotoxic with gemcitabine toward three pancreatic cancer cell lines, resulting in decreased expression of both ribonucleotide reductase regulatory subunit M2 (RRM2) and c-MYC protein (Myc) in all three cell lines.

18. miR-613 functions as a tumor suppressor in papillary thyroid carcinoma and its suppressive effect is mediated by repressing SphK2 expression

19. results were consistent across all of the four serotypes of DENV infection, which supports the pro-apoptotic role of SPHK2 in DENV-infected liver cells

20. sphingosine kinase-2 plays an important role in kidney fibrogenesis by modulating transforming growth factor-beta signaling

Mouse (Murine) Sphingosine Kinase 2 (SPHK2) interaction partners

1. High SPHK2 expression is associated with lung cancer.

2. persistent stimulation with titanium particles may lead to a consistent release of TNF-alpha and IL-6 via SPHK-2 activity, which may lead to aseptic implant loosening

3. The cell division gene PCNA was significantly overexpressed in SK2(-/-) cells, suggesting a cross regulation between sphingosine kinases and Ceramide glucosyltransferase.

4. these data demonstrate that SK-2 exerts an antiproliferative and apoptosis-sensitizing effect in renal mesangial cells which suggests that selective inhibitors of SK-2 may promote proliferation and reduce apoptosis

5. Anti-inflammatory (M2) macrophages decreased in obstructed Sphk2-/- kidneys, as did mRNA levels of inflammatory cytokines suggesting an anti-inflammatory bias in the absence of Sphk2. IL-4 or IL-13 treatment showed that macrophages lacking Sphk2 polarized more efficiently to the M2 phenotype than wild type. Sphk2 is a novel driver of the pro-inflammatory macrophage phenotype.

6. This study demonstrated that SphK2 is responsible for the vast majority of S1P synthesis in the mouse brain, and plays a role in freezing responses as evaluated in the fear conditioning paradigm.

7. The results suggest that SPK2 interacts with Bcl2 via its BH3 domain, thereby dissociating it from Beclin-1 and activating autophagy while protecting neurons against ischemic injury.

8. sphingosine kinase-2 plays an important role in kidney fibrogenesis by modulating transforming growth factor-beta signaling

9. Taken together, we conclude that antamiR-613 protects neuronal cells from OGDR probably via inducing SphK2 expression.

10. data suggest that in vitro inhibition of SK-2, can compromise the integrity of the EC monolayer

11. Results show that Sphk2/S1P has an important role to play in the survival of the dopaminergic neurons, in the pathogenesis of Parkinson's disease

12. Demonstrate that Sphk2 is the major Sphk isoform responsible for the generation of S1P in platelets and plays a pivotal intrinsic role in the control of platelet activation.

13. transcriptionally up-regulated by acute endoplasmic reticulum stress through activation of ATF4 and improves perturbed hepatic glucose and fatty acid metabolism

14. These results strongly indicate that autophagy is involved in isoflurane preconditioning both in vivo and in vitro and that SPK2 contributes to preconditioning-induced autophagy, possibly by disrupting the Beclin 1/Bcl-2 interaction.

15. SK1 and SK2 down-regulation reduces the motility of satellite cells.

16. attenuation of Sphk1, 2 activity, particularly Sphk2, leads to increased intracellular sphingolipids and autophagy in macrophages.

17. Sphk2 provides the source of intracellular S1P that controls thrombopoiesis, which is associated with Src family kinases expression and activity in megakaryocytes.

18. sphingosine kinase-2 has a role in a murine model of lupus nephritis

19. The function of SphK1 and SphK2 can be interchangeable in mast cells and is species and cell type determined.

20. Applying genetic and pharmacological approaches, we demonstrate that neuronal SPK2 isoform plays an important role in cerebral preconditioning.