SPHK2 antibody (AA 580-629)

Catalog No. ABIN1533192

The Rabbit Polyclonal anti-SPHK2 antibody is suitable to detect SPHK2 in samples from Human, Mouse and Rat. It has been validated for WB, IHC, ELISA and IF.

Quick Overview for SPHK2 antibody (AA 580-629) (ABIN1533192)

Target: SPHK2 (Sphingosine Kinase 2 (SPHK2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPHK2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-SPHK2 Antibody

Binding Specificity: AA 580-629

Purpose: SphK2 Antibody

Specificity: SphK2 Polyclonal Antibody detects endogenous levels of SphK2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human SPHK2. AA range:580-629

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for SPHK2

Target: SPHK2 (Sphingosine Kinase 2 (SPHK2))

Alternative Name: SPHK2

Background:

Synonyms: SPHK2, Sphingosine kinase 2, SK 2, SPK 2

Background: This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011],

Gene Name: SPHK2

Protein Name: Sphingosine kinase 2

Molecular Weight: 69 kDa

Gene ID: 56848

OMIM: 607092

UniProt: Q9NRA0

Pathways: VEGF Signaling